{"id":"https://openalex.org/W178332136","doi":null,"title":"Novel Cryopreservation Strategies for Cell\u2010Therapies and Pre\u2010Clinical Research","display_name":"Novel Cryopreservation Strategies for Cell\u2010Therapies and Pre\u2010Clinical Research","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W178332136","mag":"178332136"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/14122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14122","pdf_url":"http://hdl.handle.net/10362/14122","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10362/14122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074532581","display_name":"Rita Malpique","orcid":"https://orcid.org/0000-0002-5282-6790","observed_orcids":["https://orcid.org/0000-0002-5282-6790"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rita Malpique","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5282-6790","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074532581"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.1615999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.1615999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cell-banks","display_name":"cell banks","score":0.675000011920929},{"id":"https://openalex.org/keywords/tissue-bank","display_name":"tissue banking","score":0.5},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4580000042915344},{"id":"https://openalex.org/keywords/process-scalability","display_name":"process scalability","score":0.6779999732971191},{"id":"https://openalex.org/keywords/automation","display_name":"automation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/in-vitro-toxicology","display_name":"in vitro toxicology","score":0.6679999828338623},{"id":"https://openalex.org/keywords/biologics","display_name":"biologics","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.585847795009613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4233027398586273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22257766127586365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08631476759910583},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/14122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14122","pdf_url":"http://hdl.handle.net/10362/14122","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:178332136","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/14122/1/PhD%20Thesis%20Rita%20Malpique%20March%202010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/14122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14122","pdf_url":"http://hdl.handle.net/10362/14122","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3924854989","display_name":"CRYOPRESERVATION OF SOMATIC STEM CELLS FOR CELL-BASED THERAPIES","funder_award_id":"SFRH/BD/22647/2005","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7553135054","display_name":"Desenvolvimento de um sistema de cultura celular para mimetiza\u00e7\u00e3o de acidentes vasculares cerebrais in vitro: agregados de c\u00e9lulas de c\u00e9rebro como modelo.","funder_award_id":"PTDC/BIO/69407/2006","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W178332136.pdf","grobid_xml":"https://content.openalex.org/works/W178332136.grobid-xml"},"referenced_works_count":278,"referenced_works":["https://openalex.org/W24970923","https://openalex.org/W27474566","https://openalex.org/W37658540","https://openalex.org/W40033338","https://openalex.org/W45127204","https://openalex.org/W123963273","https://openalex.org/W152502414","https://openalex.org/W159733453","https://openalex.org/W170095686","https://openalex.org/W186648633","https://openalex.org/W1490494705","https://openalex.org/W1492977628","https://openalex.org/W1506233354","https://openalex.org/W1517869871","https://openalex.org/W1531301657","https://openalex.org/W1534802554","https://openalex.org/W1536544150","https://openalex.org/W1537317455","https://openalex.org/W1542303523","https://openalex.org/W1549796567","https://openalex.org/W1552814622","https://openalex.org/W1578853917","https://openalex.org/W1579340188","https://openalex.org/W1589415602","https://openalex.org/W1589876235","https://openalex.org/W1603508604","https://openalex.org/W1717506298","https://openalex.org/W1829905667","https://openalex.org/W1858842697","https://openalex.org/W1908801241","https://openalex.org/W1965413255","https://openalex.org/W1966826171","https://openalex.org/W1967025833","https://openalex.org/W1967525977","https://openalex.org/W1967817208","https://openalex.org/W1968244001","https://openalex.org/W1969836213","https://openalex.org/W1970217675","https://openalex.org/W1970258376","https://openalex.org/W1971215283","https://openalex.org/W1971540171","https://openalex.org/W1971967069","https://openalex.org/W1972961133","https://openalex.org/W1973033229","https://openalex.org/W1974258713","https://openalex.org/W1974637875","https://openalex.org/W1975796113","https://openalex.org/W1977975225","https://openalex.org/W1980329868","https://openalex.org/W1983799982","https://openalex.org/W1983810137","https://openalex.org/W1984428412","https://openalex.org/W1985389071","https://openalex.org/W1986604884","https://openalex.org/W1988671949","https://openalex.org/W1989218872","https://openalex.org/W1989243860","https://openalex.org/W1989542069","https://openalex.org/W1990787278","https://openalex.org/W1993038879","https://openalex.org/W1993309346","https://openalex.org/W1994316387","https://openalex.org/W1994986347","https://openalex.org/W1996936063","https://openalex.org/W1997121844","https://openalex.org/W1997716632","https://openalex.org/W1997815657","https://openalex.org/W1998575728","https://openalex.org/W1998610434","https://openalex.org/W1998794826","https://openalex.org/W1999785568","https://openalex.org/W2000197800","https://openalex.org/W2000458691","https://openalex.org/W2000479447","https://openalex.org/W2000717377","https://openalex.org/W2001569377","https://openalex.org/W2003226185","https://openalex.org/W2004021600","https://openalex.org/W2004475044","https://openalex.org/W2004659116","https://openalex.org/W2005340358","https://openalex.org/W2006112447","https://openalex.org/W2006976198","https://openalex.org/W2007136044","https://openalex.org/W2007902864","https://openalex.org/W2008629052","https://openalex.org/W2009057295","https://openalex.org/W2009094709","https://openalex.org/W2009573426","https://openalex.org/W2009959826","https://openalex.org/W2010761209","https://openalex.org/W2011382405","https://openalex.org/W2011669573","https://openalex.org/W2012202237","https://openalex.org/W2012593857","https://openalex.org/W2013277643","https://openalex.org/W2014583694","https://openalex.org/W2016263863","https://openalex.org/W2017431772","https://openalex.org/W2017459401","https://openalex.org/W2017476575","https://openalex.org/W2018892956","https://openalex.org/W2018924759","https://openalex.org/W2018990189","https://openalex.org/W2019665288","https://openalex.org/W2021363707","https://openalex.org/W2022236115","https://openalex.org/W2022947989","https://openalex.org/W2023045244","https://openalex.org/W2023315677","https://openalex.org/W2023448319","https://openalex.org/W2023465241","https://openalex.org/W2023945827","https://openalex.org/W2026267319","https://openalex.org/W2027563368","https://openalex.org/W2027885620","https://openalex.org/W2030205450","https://openalex.org/W2030530613","https://openalex.org/W2030800882","https://openalex.org/W2030855886","https://openalex.org/W2031778800","https://openalex.org/W2031959424","https://openalex.org/W2032126895","https://openalex.org/W2032320777","https://openalex.org/W2032564299","https://openalex.org/W2032770280","https://openalex.org/W2032914838","https://openalex.org/W2033260947","https://openalex.org/W2034499124","https://openalex.org/W2035670961","https://openalex.org/W2035814108","https://openalex.org/W2036106451","https://openalex.org/W2036378844","https://openalex.org/W2036715864","https://openalex.org/W2037273647","https://openalex.org/W2038350032","https://openalex.org/W2038665424","https://openalex.org/W2039697393","https://openalex.org/W2039975509","https://openalex.org/W2040353509","https://openalex.org/W2041454039","https://openalex.org/W2041608836","https://openalex.org/W2041888926","https://openalex.org/W2042481362","https://openalex.org/W2043386178","https://openalex.org/W2046726798","https://openalex.org/W2047351398","https://openalex.org/W2047486534","https://openalex.org/W2047940248","https://openalex.org/W2048000580","https://openalex.org/W2048454704","https://openalex.org/W2048933949","https://openalex.org/W2049067591","https://openalex.org/W2050909566","https://openalex.org/W2051306328","https://openalex.org/W2051309073","https://openalex.org/W2051350076","https://openalex.org/W2051823174","https://openalex.org/W2053193370","https://openalex.org/W2053223951","https://openalex.org/W2053515439","https://openalex.org/W2055094089","https://openalex.org/W2055297607","https://openalex.org/W2055988480","https://openalex.org/W2056620487","https://openalex.org/W2057029749","https://openalex.org/W2059684911","https://openalex.org/W2060705651","https://openalex.org/W2061128118","https://openalex.org/W2061497413","https://openalex.org/W2062333547","https://openalex.org/W2062782211","https://openalex.org/W2063512506","https://openalex.org/W2064492293","https://openalex.org/W2067337031","https://openalex.org/W2068430831","https://openalex.org/W2069275679","https://openalex.org/W2069646580","https://openalex.org/W2070679665","https://openalex.org/W2071687713","https://openalex.org/W2073696580","https://openalex.org/W2075489234","https://openalex.org/W2076105914","https://openalex.org/W2076509382","https://openalex.org/W2078196959","https://openalex.org/W2078694607","https://openalex.org/W2079054042","https://openalex.org/W2079799113","https://openalex.org/W2083715780","https://openalex.org/W2085320486","https://openalex.org/W2085445832","https://openalex.org/W2085659918","https://openalex.org/W2085789678","https://openalex.org/W2086474578","https://openalex.org/W2086700163","https://openalex.org/W2086943348","https://openalex.org/W2087691253","https://openalex.org/W2088305841","https://openalex.org/W2089231631","https://openalex.org/W2090334223","https://openalex.org/W2092142646","https://openalex.org/W2092253687","https://openalex.org/W2092417109","https://openalex.org/W2092720718","https://openalex.org/W2093281937","https://openalex.org/W2094405449","https://openalex.org/W2095022753","https://openalex.org/W2104089107","https://openalex.org/W2104269891","https://openalex.org/W2104418604","https://openalex.org/W2108467720","https://openalex.org/W2109538121","https://openalex.org/W2112392835","https://openalex.org/W2113241496","https://openalex.org/W2113999599","https://openalex.org/W2114307150","https://openalex.org/W2116978641","https://openalex.org/W2117153657","https://openalex.org/W2119402851","https://openalex.org/W2120629404","https://openalex.org/W2121438091","https://openalex.org/W2122515221","https://openalex.org/W2125654726","https://openalex.org/W2128984725","https://openalex.org/W2129873371","https://openalex.org/W2133661120","https://openalex.org/W2135519068","https://openalex.org/W2138442302","https://openalex.org/W2139513136","https://openalex.org/W2141437742","https://openalex.org/W2142038348","https://openalex.org/W2145062234","https://openalex.org/W2148863576","https://openalex.org/W2150951349","https://openalex.org/W2153195754","https://openalex.org/W2153290574","https://openalex.org/W2155723421","https://openalex.org/W2157480432","https://openalex.org/W2158669462","https://openalex.org/W2160499404","https://openalex.org/W2164911542","https://openalex.org/W2166261688","https://openalex.org/W2168293763","https://openalex.org/W2168849090","https://openalex.org/W2170043187","https://openalex.org/W2176873640","https://openalex.org/W2180445979","https://openalex.org/W2180876883","https://openalex.org/W2185096561","https://openalex.org/W2206402902","https://openalex.org/W2220223433","https://openalex.org/W2280988113","https://openalex.org/W2320713560","https://openalex.org/W2326978962","https://openalex.org/W2334610317","https://openalex.org/W2398547988","https://openalex.org/W2400999150","https://openalex.org/W2404500030","https://openalex.org/W2408429162","https://openalex.org/W2409283061","https://openalex.org/W2412435055","https://openalex.org/W2415635661","https://openalex.org/W2416648854","https://openalex.org/W2417837224","https://openalex.org/W2422864479","https://openalex.org/W2439829100","https://openalex.org/W2468034359","https://openalex.org/W2473474408","https://openalex.org/W2482710771","https://openalex.org/W2493083935","https://openalex.org/W2502683720","https://openalex.org/W2504170322","https://openalex.org/W2522724283","https://openalex.org/W2726730675","https://openalex.org/W2902903877","https://openalex.org/W3040806308","https://openalex.org/W3147740451","https://openalex.org/W4321429393"],"related_works":["https://openalex.org/W2994689255","https://openalex.org/W2556460195","https://openalex.org/W2553739358","https://openalex.org/W1982739458","https://openalex.org/W2982333022","https://openalex.org/W2347150941","https://openalex.org/W4416418991","https://openalex.org/W4404861104","https://openalex.org/W2154992904","https://openalex.org/W2396039765"],"abstract_inverted_index":{"The":[0],"expanding":[1],"need":[2],"for":[3,6],"complex":[4],"biologics":[5],"therapeutic":[7],"applications,":[8],"in\u2010vitro":[9],"pharmacology":[10],"and":[11,14,24,48,50,55],"toxicology":[12],"studies":[13],"fundamental":[15],"research":[16],"demands":[17],"the":[18,36,53,59,68],"production":[19],"of":[20,22,27,31,38,58],"banks":[21],"well\u2010characterized":[23],"safety\u2010tested":[25],"stocks":[26],"a":[28],"large":[29],"number":[30],"cell/tissue":[32],"samples.":[33],"This":[34],"implies":[35],"development":[37],"effective":[39],"cryopreservation":[40],"methodologies":[41],"that":[42],"can":[43,63],"cope":[44],"with":[45],"process":[46],"scalability":[47],"automation":[49],"must":[51],"reflect":[52],"biological":[54],"physical":[56],"properties":[57],"cells":[60],"as":[61],"these":[62],"be":[64],"significantly":[65],"altered":[66],"by":[67],"process.":[69]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
