{"id":"https://openalex.org/W1782744367","doi":null,"title":"[Efficacy and safety of glimepiride plus metformin in a single presentation, as combined therapy, in patients with type 2 diabetes mellitus and secondary failure to glibenclamide, as monotherapy].","display_name":"[Efficacy and safety of glimepiride plus metformin in a single presentation, as combined therapy, in patients with type 2 diabetes mellitus and secondary failure to glibenclamide, as monotherapy].","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W1782744367","mag":"1782744367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15612515"},"language":"es","primary_location":{"id":"pmid:15612515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15612515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009022836","display_name":"Manuel Gonz\u00e1lez-Ort\u0131\u0301z","orcid":"https://orcid.org/0000-0001-6070-0859","observed_orcids":["https://orcid.org/0000-0001-6070-0859"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Manuel Gonz\u00e1lez-Ortiz","raw_affiliation_strings":["Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiologia Clinica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal., M\u00e9xico uiec@prodigy.net.mx","Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiologia Clinica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiologia Clinica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal., M\u00e9xico uiec@prodigy.net.mx","institution_ids":["https://openalex.org/I164915025"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiologia Clinica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal., M\u00e9xico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081259084","display_name":"Esperanza Mart\u00ednez\u2010Abundis","orcid":"https://orcid.org/0000-0003-3339-2808","observed_orcids":["https://orcid.org/0000-0003-3339-2808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esperanza Mart\u00ednez-Abundis","raw_affiliation_strings":["Medicina interna (SNI 3)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicina interna (SNI 3)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1613,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"56","issue":"3","first_page":"327","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8109999895095825},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6349999904632568},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7110000252723694},{"id":"https://openalex.org/keywords/obese-patients","display_name":"obese patients","score":0.5659999847412109},{"id":"https://openalex.org/keywords/fixed-dose-combination-formulations","display_name":"fixed-dose combination formulation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.859000027179718},{"id":"https://openalex.org/keywords/biguanides","display_name":"biguanides","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.546999990940094},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.49399998784065247},{"id":"https://openalex.org/keywords/medical-nutrition-therapy","display_name":"medical nutrition therapy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.30300000309944153},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.9781566262245178},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9339081645011902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9083313941955566},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.8570822477340698},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6101356744766235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.604364275932312},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.6000556349754333},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5284352898597717},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45398324728012085},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45015567541122437},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4488787353038788},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.43166443705558777},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4146166741847992},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3164367377758026}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15612515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15612515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"Clinical Trial"},{"id":"mag:1782744367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15612515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217954978","https://openalex.org/W2592885935","https://openalex.org/W4393970550","https://openalex.org/W4399684904","https://openalex.org/W2113355164","https://openalex.org/W2589974066","https://openalex.org/W2123858549","https://openalex.org/W2371200578","https://openalex.org/W2014816693","https://openalex.org/W2138470202"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,76,81,85,96,150,154,157,159,174,186,200,224,227,231,256,259,263,280],"efficacy":[4],"and":[5,53,69,189,221,229,253,261,301,307],"safety":[6],"of":[7,62,95,103,107,112,117,131,140,156,206,214,241,246,273,286],"glimepiride":[8,113,175,287],"plus":[9,114,288],"metformin":[10,108,118,187,228,260,289],"in":[11,18,42,60,88,119,129,138,161,173,185,199,212,223,226,230,255,258,262,290,303],"a":[12,120,127,136,210,291],"single":[13,121,292],"presentation,":[14],"as":[15],"combined":[16,201,232,264,284],"therapy,":[17],"patients":[19,45,86,207,242,304],"with":[20,26,46,64,243,305],"type":[21],"2":[22,105,115],"diabetes":[23],"mellitus":[24],"(DM2)":[25],"secondary":[27,308],"failure":[28,309],"to":[29,80,100,171,183,197,298,310],"glibenclamide.":[30,311],"MATERIAL":[31],"AND":[32],"METHODS:":[33],"A":[34],"randomized,":[35],"double-blind,":[36],"multicentric":[37],"trial":[38],"was":[39,164,218,250,276],"carried":[40],"out":[41],"104":[43],"obese":[44],"DM2,":[47],"fasting":[48],"glucose":[49],">":[50,58],"140":[51],"mg/dL":[52,193],"glycated":[54],"hemoglobin":[55],"A1c":[56],"(A1C)":[57],"8%,":[59],"spite":[61],"treatment":[63],"glibenclamide":[65],"at":[66,74],"maximum":[67],"doses":[68],"medical":[70],"nutrition":[71],"therapy":[72,202,233,265],"for":[73,278,294],"least":[75],"3":[77,92,295],"months":[78,93,296],"previous":[79],"study.":[82,151],"After":[83],"randomization,":[84],"received":[87],"titrated":[89],"way":[90],"during":[91,149],"one":[94],"following":[97],"treatments:":[98],"up":[99],"4":[101,110],"mg":[102,111],"glimepiride,":[104,225,257],"g":[106,116],"or":[109,133,135,142,216,248],"presentation.":[122],"Efficacy":[123],"criteria":[124],"were":[125,146],"either":[126],"decrease":[128,160,211],"A1C":[130,139,162],"1%":[132,215],"more,":[134],"reduction":[137],"7%":[141,247],"less.":[143],"Adverse":[144],"events":[145,275],"carefully":[147],"monitored":[148],"RESULTS:":[152],"At":[153],"end":[155],"study,":[158],"concentration":[163],"-0.9":[165],"+/-":[166,178,191],"1.6%":[167],"(CI":[168,180,194],"95%:":[169,181,195],"-0.2":[170],"-1.5)":[172],"group,":[176,188],"-0.7":[177],"2.1%":[179],"0.2":[182],"-1.6)":[184],"-1.3":[190],"1.8":[192],"-0.6":[196],"-1.9)":[198],"group.":[203],"The":[204,239,271,283],"percentage":[205,240],"that":[208],"showed":[209,297],"AIC":[213,245],"higher":[217],"35.1,":[219],"21.2":[220],"47.0%":[222],"groups,":[234,266],"respectively":[235,267],"(p":[236,268],"<":[237],"0.001).":[238],"decreased":[244],"less":[249],"18.9,":[251],"9.0":[252],"23.5%":[254],"=":[269],"0.01).":[270],"frequency":[272],"adverse":[274],"similar":[277],"all":[279],"groups.":[281],"CONCLUSION:":[282],"use":[285],"presentation":[293],"be":[299],"efficacious":[300],"safe":[302],"DM2":[306]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}