{"id":"https://openalex.org/W1782280903","doi":"https://doi.org/10.1128/jvi.00438-15","title":"Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia","display_name":"Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia","publication_year":2015,"publication_date":"2015-05-14","ids":{"openalex":"https://openalex.org/W1782280903","doi":"https://doi.org/10.1128/jvi.00438-15","mag":"1782280903","pmid":"https://pubmed.ncbi.nlm.nih.gov/25972560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4505667"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00438-15","doi":"https://doi.org/10.1128/jvi.00438-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00438-15","pdf_url":"https://jvi.asm.org/content/jvi/89/15/7494.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/89/15/7494.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Susan Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Johnson","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032802994","display_name":"Michael A. Eller","orcid":"https://orcid.org/0000-0003-3905-4877","observed_orcids":["https://orcid.org/0000-0003-3905-4877"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Eller","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076427525","display_name":"Jeffrey E. Teigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey E. Teigler","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055511698","display_name":"Sebastien M. Maloveste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastien M. Maloveste","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091508214","display_name":"Bruce T. Schultz","orcid":"https://orcid.org/0000-0003-4492-9463","observed_orcids":["https://orcid.org/0000-0003-4492-9463"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce T. Schultz","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079820290","display_name":"Damien Z. Soghoian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damien Z. Soghoian","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Lu","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061109174","display_name":"Alexander F. Oster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander F. Oster","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614364","display_name":"Agn\u00e8s-Laurence Chenine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agn\u00e8s-Laurence Chenine","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059371880","display_name":"Galit Alter","orcid":"https://orcid.org/0000-0002-7680-9215","observed_orcids":["https://orcid.org/0000-0002-7680-9215","https://orcid.org/0000-0002-9221-6735","https://orcid.org/0000-0003-1570-9445"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galit Alter","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA","cRagon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"cRagon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016243200","display_name":"Ulf Dittmer","orcid":"https://orcid.org/0000-0001-9284-4849","observed_orcids":["https://orcid.org/0000-0001-9284-4849"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulf Dittmer","raw_affiliation_strings":["Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089233990","display_name":"Mary Marovich","orcid":"https://orcid.org/0000-0002-8400-3748","observed_orcids":["https://orcid.org/0000-0002-8400-3748"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Marovich","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076820552","display_name":"Merlin Lee Robb","orcid":"https://orcid.org/0000-0003-3949-9649","observed_orcids":["https://orcid.org/0000-0003-3949-9649"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merlin L. Robb","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036265394","display_name":"Nelson L. Michael","orcid":"https://orcid.org/0000-0001-5882-5548","observed_orcids":["https://orcid.org/0000-0001-5882-5548"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson L. Michael","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090836877","display_name":"Diane L. Bolton","orcid":"https://orcid.org/0000-0003-1897-499X","observed_orcids":["https://orcid.org/0000-0003-1897-499X"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Bolton","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090186450","display_name":"Hendrik Streeck","orcid":"https://orcid.org/0000-0002-0335-6390","observed_orcids":["https://orcid.org/0000-0002-0335-6390"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hendrik Streeck","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","Institute for Medical Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","eInstitute for Medical Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"Institute for Medical Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"eInstitute for Medical Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0429,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.97208855,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"89","issue":"15","first_page":"7494","last_page":"7505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.7879999876022339},{"id":"https://openalex.org/keywords/acute-hiv-infection","display_name":"acute HIV infection","score":0.8149999976158142},{"id":"https://openalex.org/keywords/viral-set-point","display_name":"viral set point","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6439999938011169},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8274391889572144},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6605165600776672},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.6434240341186523},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5814759731292725},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.579563319683075},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5745458602905273},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.5577709674835205},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4837484359741211},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4768325388431549},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47325757145881653},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.4282436966896057},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.41760382056236267},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2759416699409485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18324536085128784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07645323872566223}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00438-15","doi":"https://doi.org/10.1128/jvi.00438-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00438-15","pdf_url":"https://jvi.asm.org/content/jvi/89/15/7494.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3695461","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4505667","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4505667","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4505667","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:25972560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25972560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00438-15","doi":"https://doi.org/10.1128/jvi.00438-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00438-15","pdf_url":"https://jvi.asm.org/content/jvi/89/15/7494.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5016298822","display_name":"Modulation of HIV-specific CD8+ T and B cell function by CD4+ T helper responses","funder_award_id":"R01AI091450","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8092673686","display_name":"T follicular helper cells: Role in generation of anti-HIV antibody responses","funder_award_id":"R01AI094602","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1782280903.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1532176619","https://openalex.org/W1973619416","https://openalex.org/W1987533943","https://openalex.org/W1989723678","https://openalex.org/W1990388100","https://openalex.org/W1994408928","https://openalex.org/W2023168923","https://openalex.org/W2025481552","https://openalex.org/W2035352669","https://openalex.org/W2036182565","https://openalex.org/W2037343680","https://openalex.org/W2041426849","https://openalex.org/W2047628040","https://openalex.org/W2058237633","https://openalex.org/W2076027168","https://openalex.org/W2085005209","https://openalex.org/W2087590625","https://openalex.org/W2103182811","https://openalex.org/W2105149642","https://openalex.org/W2112887086","https://openalex.org/W2113226921","https://openalex.org/W2115180633","https://openalex.org/W2119319172","https://openalex.org/W2119722946","https://openalex.org/W2123273309","https://openalex.org/W2126338026","https://openalex.org/W2130579933","https://openalex.org/W2133706076","https://openalex.org/W2137460766","https://openalex.org/W2138085044","https://openalex.org/W2143314401","https://openalex.org/W2146166475","https://openalex.org/W2146375469","https://openalex.org/W2148360952","https://openalex.org/W2157380750","https://openalex.org/W2159131506","https://openalex.org/W2166122762","https://openalex.org/W2169004603"],"related_works":["https://openalex.org/W2132285595","https://openalex.org/W2064685433","https://openalex.org/W1990388100","https://openalex.org/W1573998654","https://openalex.org/W2017440981","https://openalex.org/W7074121736","https://openalex.org/W2128161673","https://openalex.org/W7163296387","https://openalex.org/W2495343707","https://openalex.org/W4377088166"],"abstract_inverted_index":{"UNLABELLED:":[0],"CD4+":[1,17,32,56,69,80,95,123,169,237,265,284],"T":[2,18,33,57,70,90,96,106,124,159,170,186,230,238,266,285,303],"cells":[3,34,71,81,97,107,125,171,179,187,231,239,267,278,286,297],"play":[4],"a":[5,28,73,261,280],"pivotal":[6],"role":[7,29],"in":[8,35,111,152,155,188,245,269],"the":[9,36,47,112,144,189,199,223,226,234,250,270],"control":[10,37,191,203,233,247,272],"of":[11,38,53,66,114,157,192,198,208,225,228,263,273,283,312],"chronic":[12,204],"viral":[13,136,146],"infections.":[14],"Recently,":[15],"nontraditional":[16],"cell":[19,160],"functions":[20],"beyond":[21],"helper":[22],"effects":[23],"have":[24,240],"been":[25,42,241],"described,":[26],"and":[27,50,61,108,132,215,290],"for":[30,309],"cytolytic":[31,55,68,88,94,122,168,271],"HIV":[39,130,163,193,205,246,274,313],"infection":[40,131,206],"has":[41,220],"suggested.":[43],"We":[44,257],"define":[45],"here":[46,259],"transcriptional,":[48],"phenotypic,":[49],"functional":[51],"profiles":[52],"HIV-specific":[54,67,87,93,104,264,295],"cells.":[58,91,117,304],"Fluidigm":[59],"BioMark":[60],"multiparameter":[62],"flow":[63],"cytometric":[64],"analysis":[65],"revealed":[72],"distinct":[74,176,281],"transcriptional":[75,289],"signature":[76],"compared":[77,293],"to":[78,103,143,162,202,211,232,249,294,301],"Th1":[79,178,296],"but":[82,298],"shared":[83],"similar":[84],"features":[85],"with":[86,184,299],"CD8+":[89,105,185,229,302],"Furthermore,":[92],"showed":[98],"comparable":[99],"killing":[100],"activity":[101,183],"relative":[102],"worked":[109],"cooperatively":[110],"elimination":[113],"virally":[115],"infected":[116],"Interestingly,":[118],"we":[119],"found":[120],"that":[121,180,252,260],"emerge":[126],"early":[127,145,153],"during":[128],"acute":[129,135],"tightly":[133],"follow":[134],"load":[137],"trajectory.":[138],"This":[139],"emergence":[140],"was":[141],"associated":[142],"set":[147],"point,":[148],"suggesting":[149],"an":[150,173],"involvement":[151],"control,":[154],"spite":[156],"CD4":[158],"susceptibility":[161],"infection.":[164,194],"Our":[165],"data":[166],"suggest":[167],"as":[172,243],"independent":[174],"subset":[175,262,282],"from":[177],"show":[181,258],"combined":[182],"long-term":[190],"IMPORTANCE:":[195],"The":[196],"ability":[197,227],"immune":[200],"system":[201],"is":[207],"critical":[209],"interest":[210],"both":[212],"vaccine":[213],"design":[214],"therapeutic":[216],"approaches.":[217],"Much":[218],"research":[219],"focused":[221],"on":[222],"effect":[224],"virus,":[235],"while":[236],"overlooked":[242],"effectors":[244],"due":[248],"fact":[251],"they":[253],"are":[254,307],"preferentially":[255],"infected.":[256],"cooperate":[268],"replication.":[275],"Moreover,":[276],"these":[277],"represent":[279],"showing":[287],"significant":[288],"phenotypic":[291],"differences":[292],"similarities":[300],"These":[305],"findings":[306],"important":[308],"our":[310],"understanding":[311],"immunopathology.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}