{"id":"https://openalex.org/W1781961175","doi":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","title":"The \u03b22aSubunit Is a Molecular Groom for the Ca2+Channel Inactivation Gate","display_name":"The \u03b22aSubunit Is a Molecular Groom for the Ca2+Channel Inactivation Gate","publication_year":2000,"publication_date":"2000-12-15","ids":{"openalex":"https://openalex.org/W1781961175","doi":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","mag":"1781961175","pmid":"https://pubmed.ncbi.nlm.nih.gov/11124981","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6773026"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.20-24-09046.2000","doi":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087569154","display_name":"Sophie Restituito","orcid":"https://orcid.org/0009-0002-0610-8082","observed_orcids":["https://orcid.org/0009-0002-0610-8082"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Restituito","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059971498","display_name":"Thierry Cens","orcid":"https://orcid.org/0000-0002-4109-2779","observed_orcids":["https://orcid.org/0000-0002-4109-2779"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Cens","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113660242","display_name":"Christian Barr\ufffdre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Barrere","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113581764","display_name":"Sandrine Geib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210135663","display_name":"Unit\u00e9 de Neurobiologie des canaux Ioniques et de la Synapse","ror":"https://ror.org/04d3p2m17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210111578","https://openalex.org/I4210135663"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Geib","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U464, Institut F\u00e9d\u00e9ratif Jean Roche, Laboratoire de Neurobiologie des Canaux Ioniques, 13916 Marseille Cedex 20, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U464, Institut F\u00e9d\u00e9ratif Jean Roche, Laboratoire de Neurobiologie des Canaux Ioniques, 13916 Marseille Cedex 20, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210135663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033601372","display_name":"Simon Galas","orcid":"https://orcid.org/0000-0002-1717-1266","observed_orcids":["https://orcid.org/0000-0002-1717-1266"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Galas","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027922613","display_name":"Michel MDW DE WAARD","orcid":"https://orcid.org/0000-0002-2782-9615","observed_orcids":["https://orcid.org/0000-0002-2782-9615"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210135663","display_name":"Unit\u00e9 de Neurobiologie des canaux Ioniques et de la Synapse","ror":"https://ror.org/04d3p2m17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210111578","https://openalex.org/I4210135663"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. De Waard","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U464, Institut F\u00e9d\u00e9ratif Jean Roche, Laboratoire de Neurobiologie des Canaux Ioniques, 13916 Marseille Cedex 20, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U464, Institut F\u00e9d\u00e9ratif Jean Roche, Laboratoire de Neurobiologie des Canaux Ioniques, 13916 Marseille Cedex 20, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210135663"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034956407","display_name":"Pierre Charnet","orcid":"https://orcid.org/0000-0003-4692-528X","observed_orcids":["https://orcid.org/0000-0003-4692-528X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Charnet","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 1086, Institut F\u00e9d\u00e9ratif de Recherche 24, 34293 Montpellier Cedex 05, France, and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0902,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.86676107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"20","issue":"24","first_page":"9046","last_page":"9052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta2a-subunit","display_name":"beta2a subunit","score":0.8539999723434448},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8730000257492065},{"id":"https://openalex.org/keywords/calcium-channel-inactivation","display_name":"calcium channel inactivation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/alpha1a-subunit","display_name":"alpha1A subunit","score":0.75},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.5699999928474426},{"id":"https://openalex.org/keywords/auxiliary-subunits","display_name":"auxiliary subunits","score":0.5220000147819519},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7563456296920776},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.575501561164856},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5586698651313782},{"id":"https://openalex.org/C92645518","wikidata":"https://www.wikidata.org/wiki/Q26916851","display_name":"N-type calcium channel","level":5,"score":0.5436891317367554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4809807538986206},{"id":"https://openalex.org/C174293024","wikidata":"https://www.wikidata.org/wiki/Q3001149","display_name":"R-type calcium channel","level":5,"score":0.44655951857566833},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.44537216424942017},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.4432591497898102},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4114387631416321},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.35278886556625366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26590192317962646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23708069324493408},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.14092624187469482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10230794548988342},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.06755083799362183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06111076474189758},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001464","descriptor_name":"Barium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020865","descriptor_name":"Calcium Channels, P-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020907","descriptor_name":"Calcium Channels, Q-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020907","descriptor_name":"Calcium Channels, Q-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020907","descriptor_name":"Calcium Channels, Q-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.20-24-09046.2000","doi":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6773026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6773026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:11124981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11124981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.541","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.541","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/20/24/9046.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.20-24-09046.2000","doi":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-24-09046.2000","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1503053719","https://openalex.org/W1625435902","https://openalex.org/W1965772541","https://openalex.org/W1971844027","https://openalex.org/W1972558847","https://openalex.org/W1978044131","https://openalex.org/W1978335820","https://openalex.org/W1990666024","https://openalex.org/W1992469716","https://openalex.org/W1998318605","https://openalex.org/W1998622193","https://openalex.org/W2003784210","https://openalex.org/W2004233068","https://openalex.org/W2008075340","https://openalex.org/W2011121202","https://openalex.org/W2013532971","https://openalex.org/W2025538209","https://openalex.org/W2026121960","https://openalex.org/W2037085464","https://openalex.org/W2041565818","https://openalex.org/W2044114212","https://openalex.org/W2044346944","https://openalex.org/W2059136279","https://openalex.org/W2065398045","https://openalex.org/W2066707647","https://openalex.org/W2067317104","https://openalex.org/W2071559339","https://openalex.org/W2071598044","https://openalex.org/W2072819360","https://openalex.org/W2075654108","https://openalex.org/W2082438131","https://openalex.org/W2083093113","https://openalex.org/W2083352797","https://openalex.org/W2088430439","https://openalex.org/W2090429239","https://openalex.org/W2103691662","https://openalex.org/W2131545381","https://openalex.org/W2154905702","https://openalex.org/W2164146401","https://openalex.org/W2167319899","https://openalex.org/W2426462047","https://openalex.org/W2734492868"],"related_works":["https://openalex.org/W7096836132","https://openalex.org/W2123695713","https://openalex.org/W2003145203","https://openalex.org/W2145164810","https://openalex.org/W1990666024","https://openalex.org/W2033689106","https://openalex.org/W2028451746","https://openalex.org/W2107514224","https://openalex.org/W2067690490","https://openalex.org/W1964329075"],"abstract_inverted_index":{"Ca(2+)":[0,12,16,57,108],"channel":[1,58,109,115,125,155],"inactivation":[2,82,144,156],"is":[3,29,112],"a":[4,33,69,87,137],"key":[5],"element":[6],"in":[7,149],"controlling":[8],"the":[9,20,25,50,66,73,77,96,107,129,146,151,154],"level":[10],"of":[11,36,49,68,76,81,106,118,131,143,153,161],"entry":[13],"through":[14],"voltage-gated":[15],"channels.":[17],"Interaction":[18,117],"between":[19,89],"pore-forming":[21],"alpha(1)":[22],"subunit":[23,28,52],"and":[24,91,163],"auxiliary":[26],"beta":[27,97],"known":[30],"to":[31,72],"be":[32,63],"strong":[34],"modulator":[35],"voltage-dependent":[37,132],"inactivation.":[38,59,116,133],"Here,":[39],"we":[40],"demonstrate":[41],"that":[42,104],"an":[43],"N-terminal":[44],"membrane":[45],"anchoring":[46],"site":[47],"(MAS)":[48],"beta(2a)":[51,78,84,147],"strongly":[53],"reduces":[54],"alpha(1A)":[55],"(Ca(V)2.1)":[56],"This":[60],"effect":[61],"can":[62],"mimicked":[64],"by":[65,83,145,159],"addition":[67],"transmembrane":[70],"segment":[71],"N":[74],"terminus":[75],"subunit.":[79],"Inhibition":[80],"also":[85],"requires":[86],"link":[88],"MAS":[90,162],"another":[92],"important":[93],"molecular":[94],"determinant,":[95],"interaction":[98],"domain":[99],"(BID).":[100],"Our":[101],"data":[102],"suggest":[103],"mobility":[105],"I-II":[110],"loop":[111,120],"necessary":[113],"for":[114,141],"this":[119],"with":[121],"other":[122],"identified":[123],"intracellular":[124],"domains":[126],"may":[127],"constitute":[128],"basis":[130],"We":[134],"thus":[135],"propose":[136],"conceptually":[138],"novel":[139],"mechanism":[140],"slowing":[142],"subunit,":[148],"which":[150],"immobilization":[152],"gate":[157],"occurs":[158],"means":[160],"BID.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}