{"id":"https://openalex.org/W178148381","doi":null,"title":"MCP-1/CCL2 regulation of brain endothelial tight and adherens junctions","display_name":"MCP-1/CCL2 regulation of brain endothelial tight and adherens junctions","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W178148381","mag":"178148381"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-3746","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3205744","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100448226","display_name":"Song Li","orcid":"https://orcid.org/0000-0003-2713-9136","observed_orcids":["https://orcid.org/0000-0003-2713-9136"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Song Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2713-9136","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100448226"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9100000262260437},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9660000205039978},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.996999979019165},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/caveolin-1-phosphorylation","display_name":"caveolin-1 phosphorylation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.746999979019165},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.7039999961853027},{"id":"https://openalex.org/keywords/leukocyte-extravasation","display_name":"leukocyte transmigration","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.9190510511398315},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41895225644111633},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.41268688440322876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3689688444137573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35887598991394043},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3405473232269287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25127145648002625},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.12892526388168335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10178318619728088},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.06497478485107422}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-3746","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3205744","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-3746","doi":null,"is_oa":false,"landing_page_url":"http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3205744","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:178148381","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/AAI3205744/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052709514","https://openalex.org/W6884867629","https://openalex.org/W2157179314","https://openalex.org/W4245525025","https://openalex.org/W1988551550","https://openalex.org/W2407741242","https://openalex.org/W205671022","https://openalex.org/W2008518851","https://openalex.org/W1968099474","https://openalex.org/W3008766279"],"abstract_inverted_index":{"A":[0],"readily":[1],"obtainable":[2],"in":[3,132,229,236,274,320,358],"vitro":[4,133],"paradigm":[5],"of":[6,39,46,69,77,104,111,120,147,156,181,197,224,260,293,317,360],"the":[7,78,90,112,151,179,187,193,208,215,237,246,291],"blood-brain":[8],"barrier":[9],"(BBB)":[10],"would":[11],"offer":[12],"considerable":[13],"benefits.":[14],"Towards":[15],"this":[16,118,175],"end,":[17],"we":[18],"described":[19],"a":[20,108,125,154,222,243,257,315],"novel":[21],"method":[22,34,119],"for":[23,31,329],"purifying":[24,121],"murine":[25,122,252],"brain":[26,41,152,253],"microvascular":[27,48],"endothelial":[28],"cells":[29,166],"(BMEC)":[30],"culture.":[32],"The":[33,136],"utilized":[35],"limited":[36],"collagenase/dispase":[37],"digestion":[38],"enriched":[40],"microvessels,":[42,254],"followed":[43],"by":[44,50,163,324,338],"immunoisolation":[45],"digested,":[47],"fragments":[49,65],"magnetic":[51],"beads":[52],"coated":[53],"with":[54,242,306],"antibody":[55],"to":[56,128,144,206,219,245,276],"PECAM-1.":[57],"When":[58],"plated":[59],"onto":[60],"collagen":[61],"IV-coated":[62],"surfaces,":[63],"these":[64,114,168],"elaborated":[66],"confluent":[67],"monolayers":[68],"BMEC":[70,123,347],"that":[71,117,184,195,210,352],"retained":[72],"expression":[73,103,319],"and":[74,85,98,226,263,314,332,342],"subcellular":[75],"localization":[76],"adherens":[79],"junction":[80,92],"(AJ)":[81],"-associated":[82,94],"proteins":[83,95],"VE-cadherin":[84],"\u03b2-catenin,":[86],"as":[87,89],"well":[88],"tight":[91],"(TJ)":[93],"claudin-5,":[96],"occludin":[97,227,266],"zonula":[99],"occludin-1":[100],"(ZO-1).":[101],"High":[102],"TJs":[105],"is":[106,142,172],"considered":[107],"seminal":[109],"characteristic":[110],"BBB,":[113],"results":[115,271,350],"impart":[116],"provides":[124],"suitable":[126],"platform":[127],"investigate":[129],"BBB":[130,283,361],"properties":[131],".":[134],"^":[135,288,363],"chemokine":[137,176],"monocyte":[138,343],"chemoattractant":[139],"protein":[140,228,297,308,334],"(MCP-1)":[141],"recognized":[143],"mediate":[145],"extravasation":[146],"mononuclear":[148],"leukocytes":[149,183],"into":[150],"during":[153,167,285],"variety":[155],"neuroinflammatory":[157],"conditions.":[158],"In":[159,249],"large":[160],"part":[161],"produced":[162],"parenchymal":[164],"neural":[165],"disease":[169],"states,":[170],"it":[171],"unclear":[173],"how":[174],"can":[177],"stimulate":[178],"migration":[180,345],"circulating":[182],"lie":[185],"behind":[186],"highly":[188],"impermeant":[189],"BBB.":[190],"Based":[191],"on":[192,214],"premise":[194],"disruption":[196],"TJ":[198,307,331],"could":[199],"foster":[200],"leukocyte":[201],"extravasation,":[202],"experiments":[203],"were":[204],"conducted":[205],"test":[207],"hypothesis":[209],"MCP-1":[211,220,280,294,310],"has":[212],"effects":[213],"TJ-associated":[216,296],"proteins.":[217],"Exposure":[218],"caused":[221],"loss":[223,262,316],"ZO-1":[225,232,255],"BMEC.":[230,321],"Moreover,":[231],"was":[233,303,327],"found":[234],"reduced":[235],"cytoskeletal":[238],"framework":[239],"(CSK)":[240],"fraction":[241],"shift":[244,264],"detergent-soluble":[247],"fraction.":[248],"freshly":[250],"isolated":[251],"exhibited":[256],"similar":[258],"pattern":[259],"MCP-1-induced":[261],"but":[265],"remained":[267],"nearly":[268],"constant.":[269],"These":[270,349],"indicate":[272],"that,":[273],"addition":[275],"its":[277],"chemotactic":[278],"activity,":[279],"might":[281],"alter":[282],"integrity":[284],"CNS":[286],"inflammation.":[287],"To":[289],"explore":[290],"mechanism":[292],"induced":[295],"loss,":[298],"caveolin-1":[299,312,318,353],"involved":[300],"signaling":[301],"pathway":[302],"tested.":[304],"Coincident":[305],"alteration,":[309],"provoked":[311],"phosphorylation":[313],"Caveolin-1":[322],"knockdown":[323],"siRNA":[325],"adenovirus":[326],"sufficient":[328],"several":[330],"AJ-associated":[333],"down-regulation":[335],"which":[336],"accompanied":[337],"increased":[339],"paracellular":[340],"permeability":[341],"transendothelial":[344],"across":[346],"monolayer.":[348],"implicate":[351],"plays":[354],"an":[355],"important":[356],"role":[357],"regulation":[359],"function.":[362]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
