{"id":"https://openalex.org/W178124679","doi":null,"title":"Activated retinitis pigmentosa peripheral lymphocytes adhere to and alter cultured human retinal pigment epithelial cells.","display_name":"Activated retinitis pigmentosa peripheral lymphocytes adhere to and alter cultured human retinal pigment epithelial cells.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W178124679","mag":"178124679","pmid":"https://pubmed.ncbi.nlm.nih.gov/1526734"},"language":"en","primary_location":{"id":"pmid:1526734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1526734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036764490","display_name":"Lowell L. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L L Williams","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016404399","display_name":"Ho Win Lew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H M Lew","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082412342","display_name":"Barry T. Shannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B T Shannon","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043662645","display_name":"Carl T. Singley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C T Singley","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046364501","display_name":"Robert B. Chambers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R B Chambers","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052813503","display_name":"Frederick H. Davidorf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F H Davidorf","raw_affiliation_strings":["Department of Ophthalmology, Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.02015486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":"10","first_page":"2848","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/retinal-pigment-epithelial-cells","display_name":"retinal pigment epithelial cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.796999990940094},{"id":"https://openalex.org/keywords/lymphocyte-adhesion","display_name":"lymphocyte adhesion","score":0.8460000157356262},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.7841318845748901},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4961913228034973},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.49064889550209045},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45870861411094666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4486517906188965},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.447139173746109},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44670048356056213},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.41549742221832275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3825092315673828},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.37746021151542664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29474857449531555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14813369512557983},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.147140234708786}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1526734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1526734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:178124679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1526734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2099568049","https://openalex.org/W3038074011","https://openalex.org/W3028694579","https://openalex.org/W2091008309","https://openalex.org/W1998566674","https://openalex.org/W1521642954","https://openalex.org/W2049784637","https://openalex.org/W3046198963","https://openalex.org/W2011632566","https://openalex.org/W4220798120"],"abstract_inverted_index":{"Interleukin-2":[0],"receptor":[1],"(IL-2R)":[2],"is":[3],"an":[4,24],"activation":[5,27],"molecule":[6],"that,":[7],"when":[8],"expressed":[9],"on":[10,82],"peripheral":[11],"blood":[12],"lymphocyte":[13,158],"(PBL)":[14],"membranes,":[15],"indicates":[16],"the":[17,30,88,102,105,125,131,141,184],"secretion":[18],"of":[19,23,32,70,80,84,91,104,107,127,133,157],"IL-2":[20],"and":[21,87,96,130,179,235],"initiation":[22],"immune":[25],"system":[26],"cascade.":[28],"Comparing":[29],"average":[31],"IL-2R":[33,81,128,177,201],"expression":[34,129,241],"in":[35,169,180,209,245,256],"34":[36],"patients":[37],"with":[38,51,65,110,175,216],"retinitis":[39],"pigmentosa":[40],"(RP)":[41],"syndrome":[42,149],"(561":[43],"+/-":[44,48,57],"282":[45],"cells/mm3;":[46],"mean":[47],"standard":[49],"deviation)":[50],"35":[52],"age-matched":[53],"normal":[54,165],"subjects":[55,174],"(194":[56],"39":[58],"cells/mm3),":[59],"it":[60],"was":[61,122,144,167],"found":[62,123,244],"that":[63,198,220],"those":[64],"RP":[66,86,92,108,134,148,217,222],"had":[67],"greater":[68],"numbers":[69,132],"IL-2R-positive":[71],"cells":[72,117,211,234],"(P":[73],"less":[74,205],"than":[75,164],"0.001).":[76],"The":[77],"increased":[78],"amounts":[79],"PBL":[83,93,109,170,181,197],"29":[85],"homotypic":[89],"self-aggregation":[90],"by":[94,183,195],"phase":[95],"scanning":[97],"electron":[98],"microscopy":[99],"led":[100],"to":[101,137,147,152,162,227,253],"study":[103],"interaction":[106],"cultured":[111],"human":[112],"postmortem":[113],"retinal":[114,254],"pigment":[115],"epithelial":[116],"(RPE).":[118],"A":[119,187],"direct":[120],"correlation":[121],"between":[124],"amount":[126],"lymphocytes":[135,223],"adhering":[136],"RPE":[138,163,191,210,228],"monolayers.":[139],"However,":[140],"adherence":[142,161],"effect":[143],"not":[145],"unique":[146],"but":[150,204],"appeared":[151],"be":[153,225],"a":[154],"nonspecific":[155],"result":[156],"activation.":[159],"Greater":[160],"also":[166],"observed":[168],"from":[171],"disease":[172],"control":[173],"elevated":[176],"values":[178],"stimulated":[182],"mitogen,":[185],"concanavalin":[186],"(Con-A).":[188],"In":[189],"addition,":[190],"monolayers":[192],"were":[193],"destroyed":[194],"Con-A-stimulated":[196],"showed":[199],"95-98%":[200],"expression.":[202],"Similar,":[203],"serious":[206],"effects,":[207],"occurring":[208],"after":[212],"1":[213],"wk's":[214],"cocultivation":[215],"PBL,":[218],"suggested":[219],"activated":[221],"can":[224],"cytotoxic":[226],"during":[229],"prolonged":[230],"contact.":[231],"Because":[232],"macrophage-like":[233],"class":[236],"II":[237],"major":[238],"histocompatibility":[239],"complex":[240],"have":[242],"been":[243],"RP-affected":[246],"retinas,":[247],"immune-mediated":[248],"cytopathologic":[249],"effects":[250],"may":[251],"contribute":[252],"degeneration":[255],"RP.":[257]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}