{"id":"https://openalex.org/W1781050812","doi":"https://doi.org/10.1158/1940-6207.capr-14-0334","title":"Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells","display_name":"Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells","publication_year":2015,"publication_date":"2015-10-21","ids":{"openalex":"https://openalex.org/W1781050812","doi":"https://doi.org/10.1158/1940-6207.capr-14-0334","mag":"1781050812","pmid":"https://pubmed.ncbi.nlm.nih.gov/26487401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670788"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.capr-14-0334","doi":"https://doi.org/10.1158/1940-6207.capr-14-0334","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-14-0334","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670788","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086277366","display_name":"Raymond M. Esper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond M. Esper","raw_affiliation_strings":["1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041474768","display_name":"Michael K. Dame","orcid":"https://orcid.org/0000-0003-3760-1654","observed_orcids":["https://orcid.org/0000-0003-3760-1654"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Dame","raw_affiliation_strings":["2Department of Internal Medicine Pathology, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Internal Medicine Pathology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112562583","display_name":"Shannon D. McClintock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon McClintock","raw_affiliation_strings":["2Department of Internal Medicine Pathology, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Internal Medicine Pathology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074569988","display_name":"Peter R. Holt","orcid":"https://orcid.org/0000-0002-8469-2766","observed_orcids":["https://orcid.org/0000-0002-8469-2766"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Holt","raw_affiliation_strings":["3The Rockefeller University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Rockefeller University, New York, New York","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013077524","display_name":"Andrew J. Dannenberg","orcid":"https://orcid.org/0000-0002-1901-6497","observed_orcids":["https://orcid.org/0000-0002-1901-6497"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Dannenberg","raw_affiliation_strings":["4Department of Medicine, Weill Cornell Medical College, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Medicine, Weill Cornell Medical College, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":["1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112905614","display_name":"Dean E. Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean E. Brenner","raw_affiliation_strings":["1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","5Department of Internal Medicine Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan","6VA Medical Center, Ann Arbor, Michigan","Department of Internal Medicine Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"5Department of Internal Medicine Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"6VA Medical Center, Ann Arbor, Michigan","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086277366"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":3.1184,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.91335595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"12","first_page":"1174","last_page":"1183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9879999756813049},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/leptin-to-adiponectin-ratio","display_name":"leptin/adiponectin ratio","score":0.953000009059906},{"id":"https://openalex.org/keywords/serum-adipokines","display_name":"serum adipokines","score":0.7129999995231628},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.831408679485321},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7333675622940063},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6941708326339722},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.467255562543869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4055213928222656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3955288231372833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37664979696273804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3440176248550415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33954206109046936},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.26976293325424194},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.08432114124298096}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.capr-14-0334","doi":"https://doi.org/10.1158/1940-6207.capr-14-0334","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-14-0334","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},{"id":"pmid:26487401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26487401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer prevention research (Philadelphia, Pa.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4670788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4670788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1262164151","display_name":null,"funder_award_id":"5 T32 CA 9357-32","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1840298301","display_name":"Transforming Translational Science and Education to Benefit Human Health","funder_award_id":"UL1TR000043","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8614925274","display_name":"Targeting the Obesity-Inflammation-COX-Aromatase Axis to Lower Breast Cancer Risk","funder_award_id":"R01CA154481","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881291","display_name":"Oncology Research Training Grant","funder_award_id":"T32CA009357","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W48270215","https://openalex.org/W1561443084","https://openalex.org/W1573852501","https://openalex.org/W1816419917","https://openalex.org/W1866017223","https://openalex.org/W1937299243","https://openalex.org/W1964888481","https://openalex.org/W1965008951","https://openalex.org/W1967758113","https://openalex.org/W1971452427","https://openalex.org/W1975002723","https://openalex.org/W1983160228","https://openalex.org/W1983161536","https://openalex.org/W1987949508","https://openalex.org/W1995311865","https://openalex.org/W1996713062","https://openalex.org/W1997847812","https://openalex.org/W2006166466","https://openalex.org/W2012496594","https://openalex.org/W2023316892","https://openalex.org/W2024196852","https://openalex.org/W2024568573","https://openalex.org/W2031356554","https://openalex.org/W2045948521","https://openalex.org/W2048942491","https://openalex.org/W2052057604","https://openalex.org/W2054140940","https://openalex.org/W2077740357","https://openalex.org/W2088668395","https://openalex.org/W2091396367","https://openalex.org/W2099061048","https://openalex.org/W2101885447","https://openalex.org/W2111098276","https://openalex.org/W2111688257","https://openalex.org/W2113493868","https://openalex.org/W2117977995","https://openalex.org/W2118368630","https://openalex.org/W2124254475","https://openalex.org/W2127617517","https://openalex.org/W2129877262","https://openalex.org/W2130670142","https://openalex.org/W2143768482","https://openalex.org/W2152189081","https://openalex.org/W2155226662","https://openalex.org/W2157795870","https://openalex.org/W2163210258","https://openalex.org/W2165286055","https://openalex.org/W2167596697","https://openalex.org/W2170924429","https://openalex.org/W2417005263","https://openalex.org/W2762697978","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2561711916","https://openalex.org/W1973993280","https://openalex.org/W153121280","https://openalex.org/W2147929281","https://openalex.org/W2157795870","https://openalex.org/W1848483485","https://openalex.org/W2810136617","https://openalex.org/W2032325264","https://openalex.org/W1533159501","https://openalex.org/W1980183623"],"abstract_inverted_index":{"Multiple":[0],"mechanisms":[1],"are":[2,23],"likely":[3],"to":[4,28,123,135,211],"account":[5],"for":[6,85,179,191],"the":[7,40,45,69,72,95,136,192,213,216,235],"link":[8,137],"between":[9,94,138],"obesity":[10,139],"and":[11,21,33,49,102,131,140,147,201,208,226],"increased":[12,169],"risk":[13,236],"of":[14,24,47,58,71,145,150,215,237],"postmenopausal":[15,162,196],"breast":[16,36,53,74,103,117,141,197,229,238],"cancer.":[17,142,239],"Two":[18],"adipokines,":[19],"leptin":[20,48,59,112,130,146],"adiponectin,":[22,132],"particular":[25],"interest":[26],"due":[27],"their":[29],"opposing":[30],"biologic":[31],"functions":[32],"associations":[34],"with":[35,68,108,159,176],"cancer":[37,198],"risk.":[38,199],"In":[39,78,121],"current":[41],"study,":[42],"we":[43],"investigated":[44],"effects":[46],"adiponectin":[50,115,151,202],"on":[51],"normal":[52,73,217],"epithelial":[54],"stem":[55,75,104,118,170,218,230],"cells.":[56],"Levels":[57],"in":[60,98,154,195],"human":[61],"adipose":[62,99],"explant-derived":[63],"conditioned":[64,100],"media":[65,101],"positively":[66],"correlated":[67],"size":[70,214],"cell":[76,105,119,171,219,231],"pool.":[77,220],"contrast,":[79],"an":[80],"inverse":[81],"relationship":[82,91],"was":[83,92],"found":[84,153],"adiponectin.":[86],"Moreover,":[87],"a":[88,188],"strong":[89],"linear":[90],"observed":[93],"leptin/adiponectin":[96],"ratio":[97],"self-renewal.":[106,120],"Consistent":[107],"these":[109,185],"findings,":[110],"exogenous":[111],"stimulated":[113],"whereas":[114],"suppressed":[116],"addition":[122],"local":[124],"in-breast":[125],"effects,":[126],"circulating":[127],"factors,":[128],"including":[129],"may":[133,203],"contribute":[134],"Increased":[143],"levels":[144],"reduced":[148],"amounts":[149],"were":[152],"serum":[155,165],"from":[156,166],"obese":[157,167],"compared":[158,175],"age-matched":[160],"lean":[161,180],"women.":[163],"Interestingly,":[164],"women":[168],"self-renewal":[172,232],"by":[173],"30%":[174],"only":[177],"7%":[178],"control":[181],"serum.":[182],"Taken":[183],"together,":[184],"data":[186],"suggest":[187],"plausible":[189],"explanation":[190],"obesity-driven":[193],"increase":[194],"Leptin":[200],"function":[204],"as":[205],"both":[206],"endocrine":[207],"paracrine/juxtacrine":[209],"factors":[210],"modulate":[212],"Interventions":[221],"that":[222],"disrupt":[223],"this":[224],"axis":[225],"thereby":[227],"normalize":[228],"could":[233],"reduce":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}