{"id":"https://openalex.org/W178019285","doi":null,"title":"RAS gene mutations in multiple myeloma and related monoclonal gammopathies.","display_name":"RAS gene mutations in multiple myeloma and related monoclonal gammopathies.","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W178019285","mag":"178019285","pmid":"https://pubmed.ncbi.nlm.nih.gov/1921261"},"language":"en","primary_location":{"id":"pmid:1921261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1921261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Kobe journal of medical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.14094/E0034082","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000253275","display_name":"Sachiko Matozaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Matozaki","raw_affiliation_strings":["Department of Hematology/Oncology, Hyogo Medical Center for Adult, Akashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Hyogo Medical Center for Adult, Akashi","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nakagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109649309","display_name":"Y Nakao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nakao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103394027","display_name":"Takuya Fujita","orcid":"https://orcid.org/0000-0002-7724-6522","observed_orcids":["https://orcid.org/0000-0002-7724-6522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2634,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.51634921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"1","first_page":"35","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/monoclonal-gammopathy-of-undetermined-significance","display_name":"monoclonal gammopathy of undetermined significance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.8330000042915344},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9980000257492065},{"id":"https://openalex.org/keywords/solitary-plasmacytoma","display_name":"solitary plasmacytoma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5419999957084656},{"id":"https://openalex.org/keywords/codon-12-mutation","display_name":"codon 12 mutation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/codon-61-mutation","display_name":"codon 61 mutation","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2777250017","wikidata":"https://www.wikidata.org/wiki/Q458138","display_name":"Monoclonal gammopathy of undetermined significance","level":5,"score":0.7371219396591187},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7027663588523865},{"id":"https://openalex.org/C2778964538","wikidata":"https://www.wikidata.org/wiki/Q2090167","display_name":"Plasmacytoma","level":3,"score":0.6663231253623962},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.6483808755874634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5398731231689453},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5122475028038025},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4845949411392212},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4676760137081146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.466079443693161},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45929378271102905},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4115491509437561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3878825604915619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37636861205101013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3537554144859314},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3106372058391571},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22119620442390442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17273110151290894},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12569454312324524}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1921261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1921261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Kobe journal of medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:da.lib.kobe-u.ac.jp:20.500.14094/E0034082","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14094/E0034082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401924","display_name":"Kobe University Repository Kernel (Kobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I65837984","host_organization_name":"Kobe University","host_organization_lineage":["https://openalex.org/I65837984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Kobe journal of the medical sciences\u300037(1), 35-45","raw_type":"departmental bulletin paper"},{"id":"mag:178019285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1921261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:da.lib.kobe-u.ac.jp:20.500.14094/E0034082","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14094/E0034082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401924","display_name":"Kobe University Repository Kernel (Kobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I65837984","host_organization_name":"Kobe University","host_organization_lineage":["https://openalex.org/I65837984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Kobe journal of the medical sciences\u300037(1), 35-45","raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967515087","https://openalex.org/W7217822240","https://openalex.org/W7217788266","https://openalex.org/W2395919070","https://openalex.org/W2356217487","https://openalex.org/W2055927459","https://openalex.org/W2080164596","https://openalex.org/W7217177600","https://openalex.org/W66769261","https://openalex.org/W2003442933"],"abstract_inverted_index":{"The":[0],"presence":[1,71],"of":[2,17,26,48,72,91,98,104,111,114,121],"RAS":[3,49,123],"gene":[4,76,93],"mutations":[5,77,124],"in":[6,13,51,96,127],"precancerous":[7],"lesions":[8],"suggests":[9],"that":[10],"they":[11],"participate":[12],"the":[14,45,70,99,105,112,115,119],"early":[15],"stages":[16],"neoplastic":[18,21],"development.":[19],"Furthermore,":[20],"progression":[22],"from":[23,58],"monoclonal":[24,55,62],"gammopathy":[25],"undetermined":[27],"significance":[28],"(MGUS)":[29],"to":[30,43],"overt":[31],"multiple":[32],"myeloma":[33],"(MM)":[34],"have":[35],"been":[36],"frequently":[37],"observed.":[38],"These":[39],"observations":[40],"prompted":[41],"us":[42],"study":[44],"pathogenetic":[46],"role":[47],"genes":[50],"MM":[52,66,101],"and":[53,74,109],"related":[54],"gammopathies.":[56],"DNA":[57],"18":[59],"patients":[60,108],"with":[61],"gamma-globulinemia":[63],"including":[64],"12":[65,100],"were":[67,94,125],"investigated":[68],"for":[69],"N-":[73],"K-RAS":[75],"by":[78],"polymerase":[79],"chain":[80],"reaction":[81],"(PCR)/oligonucleotide":[82],"hybridization.":[83],"Mutations":[84],"involving":[85],"codons":[86],"12,":[87],"13":[88],"or":[89],"61":[90],"N-RAS":[92],"identified":[95],"3":[97,113],"patients,":[102],"1":[103],"solitary":[106],"plasmacytoma":[107],"none":[110],"MGUS":[116],"patients.":[117],"In":[118],"case":[120],"plasmacytoma,":[122],"detected":[126],"his":[128],"bone":[129],"marrow":[130],"specimens.":[131]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}