{"id":"https://openalex.org/W1779840652","doi":null,"title":"The pathophysiology of chronic osteomyelitis","display_name":"The pathophysiology of chronic osteomyelitis","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W1779840652","mag":"1779840652"},"language":"en","primary_location":{"id":"mag:1779840652","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.org.za/pdf/saoj/v12n4/03.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2765016097","display_name":"The South African Orthopaedic Journal (SAOJ)","issn_l":"1681-150X","issn":["1681-150X","2309-8309"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315365","host_organization_name":"South African Orthopaedic Association","host_organization_lineage":["https://openalex.org/P4310315365"],"host_organization_lineage_names":["South African Orthopaedic Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The South African Orthopaedic Journal (SAOJ)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scielo.org.za/pdf/saoj/v12n4/03.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017630249","display_name":"Nando Ferreira","orcid":"https://orcid.org/0000-0002-0567-3373","observed_orcids":["https://orcid.org/0000-0002-0567-3373"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nando Ferreira","raw_affiliation_strings":["University of KwaZulu Natal"],"raw_orcid":"https://orcid.org/0000-0002-0567-3373","affiliations":[{"raw_affiliation_string":"University of KwaZulu Natal","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005459204","display_name":"Carol R. Aldous","orcid":"https://orcid.org/0000-0002-2926-1736","observed_orcids":["https://orcid.org/0000-0002-2926-1736","https://orcid.org/0000-0002-7199-9160"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"C Aldous","raw_affiliation_strings":["University of KwaZulu Natal"],"raw_orcid":"https://orcid.org/0000-0002-2926-1736","affiliations":[{"raw_affiliation_string":"University of KwaZulu Natal","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022018763","display_name":"LC Marais","orcid":"https://orcid.org/0000-0002-1120-8419","observed_orcids":["https://orcid.org/0000-0002-1120-8419"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"LC Marais","raw_affiliation_strings":["University of KwaZulu Natal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu Natal","institution_ids":["https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95023434"],"apc_list":null,"apc_paid":null,"fwci":0.3187,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60548362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"12","issue":"4","first_page":"14","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-osteomyelitis","display_name":"chronic osteomyelitis","score":1.0},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bone-infection","display_name":"bone infection","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8159999847412109},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.6840000152587891},{"id":"https://openalex.org/keywords/osteoimmunology","display_name":"osteoimmunology","score":0.9340000152587891},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9739999771118164},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":1.0},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.875},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.7903366088867188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7389342784881592},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.62126624584198},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5730594992637634},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5027782917022705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43807467818260193},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43776342272758484},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.43387559056282043},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.41671204566955566},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3391574025154114},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29244768619537354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1847842037677765},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11182758212089539},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1779840652","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.org.za/pdf/saoj/v12n4/03.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2765016097","display_name":"The South African Orthopaedic Journal (SAOJ)","issn_l":"1681-150X","issn":["1681-150X","2309-8309"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315365","host_organization_name":"South African Orthopaedic Association","host_organization_lineage":["https://openalex.org/P4310315365"],"host_organization_lineage_names":["South African Orthopaedic Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The South African Orthopaedic Journal (SAOJ)","raw_type":null}],"best_oa_location":{"id":"mag:1779840652","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.org.za/pdf/saoj/v12n4/03.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2765016097","display_name":"The South African Orthopaedic Journal (SAOJ)","issn_l":"1681-150X","issn":["1681-150X","2309-8309"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315365","host_organization_name":"South African Orthopaedic Association","host_organization_lineage":["https://openalex.org/P4310315365"],"host_organization_lineage_names":["South African Orthopaedic Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The South African Orthopaedic Journal (SAOJ)","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W14869533","https://openalex.org/W57245347","https://openalex.org/W82482687","https://openalex.org/W1507694053","https://openalex.org/W1538511001","https://openalex.org/W1646391525","https://openalex.org/W1872749100","https://openalex.org/W1983255179","https://openalex.org/W2004891301","https://openalex.org/W2005955658","https://openalex.org/W2009041427","https://openalex.org/W2011798736","https://openalex.org/W2013194745","https://openalex.org/W2018565672","https://openalex.org/W2036513380","https://openalex.org/W2044433375","https://openalex.org/W2046450837","https://openalex.org/W2059928714","https://openalex.org/W2061514792","https://openalex.org/W2084913103","https://openalex.org/W2102609863","https://openalex.org/W2107650019","https://openalex.org/W2107656502","https://openalex.org/W2110498109","https://openalex.org/W2125603952","https://openalex.org/W2132897561","https://openalex.org/W2136734720","https://openalex.org/W2142880372","https://openalex.org/W2154366164","https://openalex.org/W2154710140","https://openalex.org/W2162328709","https://openalex.org/W2175288427","https://openalex.org/W2203526071","https://openalex.org/W2321102652","https://openalex.org/W2737909017"],"related_works":["https://openalex.org/W2959071814","https://openalex.org/W3023934906","https://openalex.org/W4414548596","https://openalex.org/W3194872319","https://openalex.org/W2081203690","https://openalex.org/W1698829405","https://openalex.org/W2941352209","https://openalex.org/W2132897561","https://openalex.org/W7159639498","https://openalex.org/W2098172959"],"abstract_inverted_index":{"Chronic":[0],"osteomyelitis":[1,122],"is":[2,71],"a":[3,83,95],"biofilm-based":[4],"infection":[5,70],"of":[6,11,47,65,90,98,102,110,113,120],"bone":[7,91],"where":[8],"the":[9,34,51,66,87,111,118],"majority":[10],"causative":[12],"microorganisms":[13],"are":[14,33,42],"sessile":[15],"in":[16,58,86,94,108,117],"nature,":[17],"rendering":[18],"them":[19],"less":[20],"sensitive":[21],"to":[22,45,53,60,69],"systemic":[23],"antibiotic":[24],"agents":[25],"and":[26,41,79,123],"making":[27],"routine":[28],"culture":[29],"techniques":[30],"unreliable.":[31],"Biofilms":[32],"characteristic":[35],"growth":[36],"pattern":[37],"for":[38],"most":[39],"bacteria":[40],"now":[43],"understood":[44],"consist":[46],"interactive":[48],"communities":[49],"with":[50],"ability":[52],"alter":[54],"their":[55],"gene":[56],"expression":[57],"order":[59],"ensure":[61],"survival.":[62],"Our":[63],"knowledge":[64,103],"host\u2019s":[67],"response":[68,89],"also":[72],"rapidly":[73],"expanding.":[74],"The":[75],"discovery":[76],"that":[77],"osteoclastic":[78],"osteoblastic":[80],"cells":[81],"play":[82],"central":[84],"role":[85],"immune":[88],"has":[92,104],"resulted":[93],"better":[96],"understanding":[97],"osteo-immunology.":[99],"This":[100],"expansion":[101],"created":[105],"new":[106],"opportunities":[107],"terms":[109],"development":[112],"novel":[114],"treatment":[115],"strategies":[116],"management":[119],"chronic":[121],"periprosthetic":[124],"infections.":[125]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}