{"id":"https://openalex.org/W1778286941","doi":null,"title":"Gene silencing mechanisms in Phytophthora infestans","display_name":"Gene silencing mechanisms in Phytophthora infestans","publication_year":2012,"publication_date":"2012-05-30","ids":{"openalex":"https://openalex.org/W1778286941","mag":"1778286941"},"language":"en","primary_location":{"id":"pmh:oai:pub.epsilon.slu.se:8917","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8917/1/Vetukuri_R.R_120530.pdf","pdf_url":"https://pub.epsilon.slu.se/8917/11/vetukuri_r_120621_errata.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pub.epsilon.slu.se/8917/11/vetukuri_r_120621_errata.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019360582","display_name":"Ramesh Raju Vetukuri","orcid":"https://orcid.org/0000-0001-7129-5326","observed_orcids":["https://orcid.org/0000-0001-7129-5326"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramesh R. Vetukuri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7129-5326","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019360582"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11771","display_name":"Plant Pathogens and Resistance","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11771","display_name":"Plant Pathogens and Resistance","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytophthora-infestans","display_name":"Phytophthora infestans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rna-silencing","display_name":"RNA silencing","score":0.925000011920929},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7080000042915344},{"id":"https://openalex.org/keywords/dicer-like-proteins","display_name":"Dicer-like proteins","score":0.6579999923706055},{"id":"https://openalex.org/keywords/argonaute-proteins","display_name":"Argonaute proteins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8080000281333923},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.8360000252723694},{"id":"https://openalex.org/keywords/small-rna","display_name":"small RNA","score":0.8569999933242798},{"id":"https://openalex.org/keywords/rxlr-effectors","display_name":"RXLR effectors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/effector-gene-expression","display_name":"effector gene expression","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8218841552734375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6312813758850098},{"id":"https://openalex.org/C2777257142","wikidata":"https://www.wikidata.org/wiki/Q149072","display_name":"Phytophthora infestans","level":3,"score":0.6020752787590027},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5975537300109863},{"id":"https://openalex.org/C179138559","wikidata":"https://www.wikidata.org/wiki/Q24740158","display_name":"Chromodomain","level":5,"score":0.5604086518287659},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.48466354608535767},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.481469064950943},{"id":"https://openalex.org/C155330019","wikidata":"https://www.wikidata.org/wiki/Q21106117","display_name":"RNA-induced silencing complex","level":5,"score":0.4751013517379761},{"id":"https://openalex.org/C172827444","wikidata":"https://www.wikidata.org/wiki/Q7277128","display_name":"RNA-induced transcriptional silencing","level":5,"score":0.4578685760498047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44372260570526123},{"id":"https://openalex.org/C201853390","wikidata":"https://www.wikidata.org/wiki/Q413236","display_name":"Argonaute","level":5,"score":0.4243873059749603},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4084581136703491},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26332181692123413},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1851549744606018},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.11410948634147644}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pub.epsilon.slu.se:8917","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8917/1/Vetukuri_R.R_120530.pdf","pdf_url":"https://pub.epsilon.slu.se/8917/11/vetukuri_r_120621_errata.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1778286941","doi":null,"is_oa":false,"landing_page_url":"https://pub.epsilon.slu.se/8917/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pub.epsilon.slu.se:8917","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8917/1/Vetukuri_R.R_120530.pdf","pdf_url":"https://pub.epsilon.slu.se/8917/11/vetukuri_r_120621_errata.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1778286941.pdf"},"referenced_works_count":185,"referenced_works":["https://openalex.org/W65147630","https://openalex.org/W144423133","https://openalex.org/W157680103","https://openalex.org/W327097133","https://openalex.org/W1500597910","https://openalex.org/W1540562551","https://openalex.org/W1563716218","https://openalex.org/W1569172974","https://openalex.org/W1586699733","https://openalex.org/W1647075334","https://openalex.org/W1839095954","https://openalex.org/W1848948524","https://openalex.org/W1854111185","https://openalex.org/W1917050948","https://openalex.org/W1963743411","https://openalex.org/W1965194855","https://openalex.org/W1967339666","https://openalex.org/W1967436682","https://openalex.org/W1967543716","https://openalex.org/W1967760135","https://openalex.org/W1969966687","https://openalex.org/W1971833648","https://openalex.org/W1975664900","https://openalex.org/W1977008256","https://openalex.org/W1977604373","https://openalex.org/W1978542189","https://openalex.org/W1979315891","https://openalex.org/W1986507106","https://openalex.org/W1987526931","https://openalex.org/W1991382981","https://openalex.org/W1991729556","https://openalex.org/W1992170226","https://openalex.org/W1992908505","https://openalex.org/W1993314573","https://openalex.org/W1993671611","https://openalex.org/W1994155714","https://openalex.org/W1994420512","https://openalex.org/W1999840011","https://openalex.org/W1999886327","https://openalex.org/W2003922337","https://openalex.org/W2003971681","https://openalex.org/W2004271888","https://openalex.org/W2006291275","https://openalex.org/W2008462001","https://openalex.org/W2009206848","https://openalex.org/W2009326616","https://openalex.org/W2010012072","https://openalex.org/W2011749504","https://openalex.org/W2012331775","https://openalex.org/W2014704298","https://openalex.org/W2015117929","https://openalex.org/W2015858554","https://openalex.org/W2015969705","https://openalex.org/W2017014505","https://openalex.org/W2017048824","https://openalex.org/W2018567821","https://openalex.org/W2019420851","https://openalex.org/W2021735982","https://openalex.org/W2022685385","https://openalex.org/W2024316824","https://openalex.org/W2024829095","https://openalex.org/W2026222098","https://openalex.org/W2026519705","https://openalex.org/W2026936889","https://openalex.org/W2027279590","https://openalex.org/W2030489111","https://openalex.org/W2033518550","https://openalex.org/W2034206562","https://openalex.org/W2040210770","https://openalex.org/W2040400351","https://openalex.org/W2044131517","https://openalex.org/W2044285871","https://openalex.org/W2045206414","https://openalex.org/W2045389027","https://openalex.org/W2046318418","https://openalex.org/W2046486243","https://openalex.org/W2046486371","https://openalex.org/W2047608141","https://openalex.org/W2048971737","https://openalex.org/W2054562396","https://openalex.org/W2056507135","https://openalex.org/W2057162139","https://openalex.org/W2057985512","https://openalex.org/W2059357290","https://openalex.org/W2060428635","https://openalex.org/W2062188301","https://openalex.org/W2065273952","https://openalex.org/W2067442982","https://openalex.org/W2067971481","https://openalex.org/W2068847708","https://openalex.org/W2071541955","https://openalex.org/W2073014932","https://openalex.org/W2074705275","https://openalex.org/W2074990432","https://openalex.org/W2075151337","https://openalex.org/W2075635829","https://openalex.org/W2079320075","https://openalex.org/W2080288062","https://openalex.org/W2082997857","https://openalex.org/W2089473922","https://openalex.org/W2091917545","https://openalex.org/W2094057862","https://openalex.org/W2096228494","https://openalex.org/W2096614996","https://openalex.org/W2096710722","https://openalex.org/W2097428904","https://openalex.org/W2098638380","https://openalex.org/W2099601586","https://openalex.org/W2100001046","https://openalex.org/W2100209874","https://openalex.org/W2100451532","https://openalex.org/W2100609243","https://openalex.org/W2100932663","https://openalex.org/W2101000074","https://openalex.org/W2103574752","https://openalex.org/W2105284421","https://openalex.org/W2105456389","https://openalex.org/W2106147903","https://openalex.org/W2107330252","https://openalex.org/W2108780882","https://openalex.org/W2109036466","https://openalex.org/W2110645824","https://openalex.org/W2110647335","https://openalex.org/W2111291916","https://openalex.org/W2112732396","https://openalex.org/W2117991391","https://openalex.org/W2118201962","https://openalex.org/W2118420574","https://openalex.org/W2120867442","https://openalex.org/W2123507267","https://openalex.org/W2124774982","https://openalex.org/W2124866820","https://openalex.org/W2125346459","https://openalex.org/W2125482231","https://openalex.org/W2126769883","https://openalex.org/W2127497651","https://openalex.org/W2130487105","https://openalex.org/W2130501807","https://openalex.org/W2130799675","https://openalex.org/W2131496416","https://openalex.org/W2132603578","https://openalex.org/W2132671821","https://openalex.org/W2133313719","https://openalex.org/W2133767887","https://openalex.org/W2134663818","https://openalex.org/W2134827765","https://openalex.org/W2136413284","https://openalex.org/W2137037625","https://openalex.org/W2137285170","https://openalex.org/W2137519022","https://openalex.org/W2138043022","https://openalex.org/W2138664009","https://openalex.org/W2139582953","https://openalex.org/W2140105907","https://openalex.org/W2140177375","https://openalex.org/W2143430694","https://openalex.org/W2144537559","https://openalex.org/W2144877714","https://openalex.org/W2144897399","https://openalex.org/W2151435150","https://openalex.org/W2151809557","https://openalex.org/W2154166273","https://openalex.org/W2156154309","https://openalex.org/W2159086557","https://openalex.org/W2159321216","https://openalex.org/W2160506991","https://openalex.org/W2160619010","https://openalex.org/W2161305024","https://openalex.org/W2162515800","https://openalex.org/W2163199119","https://openalex.org/W2163298865","https://openalex.org/W2163413931","https://openalex.org/W2165258218","https://openalex.org/W2166871032","https://openalex.org/W2167833700","https://openalex.org/W2168909179","https://openalex.org/W2170703994","https://openalex.org/W2170740776","https://openalex.org/W2171482869","https://openalex.org/W2171527563","https://openalex.org/W2235508011","https://openalex.org/W2540565673","https://openalex.org/W2608860640","https://openalex.org/W2991460120","https://openalex.org/W7095995113"],"related_works":["https://openalex.org/W1848948524","https://openalex.org/W2127407961","https://openalex.org/W2142013107","https://openalex.org/W2070443036","https://openalex.org/W1993671611","https://openalex.org/W2003984381","https://openalex.org/W1979116643","https://openalex.org/W7032163453","https://openalex.org/W2159086557","https://openalex.org/W2100609243"],"abstract_inverted_index":{"The":[0,136,159],"hemibiotrophic":[1],"oomycete,":[2],"Phytophthora":[3],"infestans,":[4],"causes":[5],"late":[6],"blight":[7],"on":[8,30],"potato":[9],"and":[10,41,51,100,134,147,157,164,181,223,244,280,315,344,351,357,369],"tomato.":[11],"This":[12,27],"destructive":[13],"pathogen":[14],"is":[15,128,153,327],"well":[16],"known":[17],"for":[18,309],"the":[19,31,42,162,179,210,220,240],"rapidity":[20],"with":[21,85],"which":[22],"it":[23,44,228],"overcomes":[24],"host":[25],"resistance.":[26],"thesis":[28],"focuses":[29],"molecular":[32],"basis":[33],"of":[34,97,122,130,143,188,207,218,242,248,258,265,285,313,323,330,337,366],"gene":[35,62,90,214,317],"(RNA)":[36],"silencing":[37,114,217,336,359],"in":[38,47,89,110,115,178,252,272,299,306,360],"P.":[39,116,123,232,267,361],"infestans":[40,124,233,268,362],"role":[43,88],"may":[45],"have":[46,363],"its":[48],"genome":[49,121,137,151],"biology":[50],"pathogenesis.":[52],"A":[53,202],"comparative":[54],"genomic":[55,352],"approach":[56],"identified":[57],"51":[58],"genes":[59,160],"from":[60,260,291],"nine":[61],"families,":[63],"encoding":[64,161,250],"Dicer-like":[65],"(PiDcl1),":[66],"Argonaute":[67,316,338],"(PiAgo),":[68],"RNA-dependent":[69],"RNA":[70,236,358],"polymerase":[71],"(PiRdr1),":[72],"Histone":[73],"eacetylases,":[74],"histone":[75],"methyltransferases,":[76],"DEAD":[77],"helicases,":[78],"chromodomain":[79],"proteins,and":[80],"a":[81,86,139,144,193],"class":[82],"1":[83],"RNaseIII":[84],"possible":[87],"silencing.":[91],"It":[92],"was":[93,229,333],"shown":[94],"by":[95,155,335],"knockdown":[96],"PiDcl1,":[98],"\\nPiAgo1,":[99],"PiHda1":[101],"(Histone":[102],"deacetylase)":[103],"expression,":[104],"that":[105,152,169,231,270,287,321,346],"these":[106],"components":[107],"were":[108,200,288,296,354],"involved":[109],"maintaining":[111],"transcriptional":[112,205],"(heterochromatic)":[113],"infestans.":[117],"\\n":[118,255,371],"\\nThe":[119],"large":[120],"(~":[125],"240":[126],"Mb)":[127],"composed":[129],"approximately":[131],"75%":[132],"transposons":[133,156,243],"repeats.":[135,158],"has":[138],"bimodal":[140],"architecture,":[141],"consisting":[142],"highly":[145],"conserved":[146],"tightly":[148],"packed":[149],"core":[150],"interrupted":[154],"RxLR":[163],"Crinkler":[165],"(CRN)":[166],"effector":[167,213,249],"classes":[168,284],"are":[170,175],"critical":[171],"to":[172,192,209,216,238,348],"plant":[173],"infection":[174],"predominantly":[176,289],"located":[177],"repeat":[180],"\\ntransposon":[182],"rich":[183],"regions.":[184],"Small":[185],"RNAs":[186],"(sRNA)":[187],"40":[189],"nt,":[190],"homologous":[191,225],"non-autonomous":[194],"short":[195],"interspersed":[196],"retrotransposable":[197],"element":[198],"infSINEm":[199,208],"found.":[201],"sense":[203],"orientation":[204],"fusion":[206,222],"PiAvr3a":[211],"(RxLR)":[212],"led":[215],"both":[219,300,367],"introduced":[221],"endogenous":[224],"sequences.":[226],"Hence,":[227],"concluded":[230],"likely":[234],"uses":[235],"\\nsilencing":[237],"minimize":[239],"activity":[241],"might":[245],"influence":[246],"expression":[247,318],"\\ngenes":[251],"close":[253],"proximity.":[254],"\\nDeep":[256],"sequencing":[257],"sRNA":[259],"different":[261],"life":[262],"cycle":[263],"stages":[264],"two":[266],"isolates,":[269,301],"differ":[271],"their":[273],"disease":[274],"causing":[275],"abilities,":[276],"revealed":[277],"21,":[278],"25/26,":[279],"32":[281],"nt":[282,325],"size":[283],"sRNAs":[286,295,326,332,345,356],"derived":[290],"transposons.":[292],"Effector":[293],"gene-derived":[294],"also":[297],"present":[298],"but":[302],"exhibited":[303],"marked":[304],"differences":[305],"abundance,":[307],"especially":[308],"CRN":[310],"effectors.":[311],"Knockdown":[312],"\\nDicer":[314],"provided":[319],"evidence":[320],"biogenesis":[322],"21":[324],"Dicerdependent,while":[328],"accumulation":[329],"longer":[331],"impacted":[334],"genes.":[339],"Additionally,":[340],"six":[341],"miRNA":[342],"candidates,":[343],"mapped":[347],"mitochondrial,":[349],"tRNA":[350],"\\nhotspots":[353],"identified.":[355],"features":[364],"characteristic":[365],"plants":[368],"animals.":[370]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
