{"id":"https://openalex.org/W177589616","doi":null,"title":"Environmental risk factors for amyotrophic lateral sclerosis: methodological issues in epidemiologic studies.","display_name":"Environmental risk factors for amyotrophic lateral sclerosis: methodological issues in epidemiologic studies.","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W177589616","mag":"177589616","pmid":"https://pubmed.ncbi.nlm.nih.gov/23193897"},"language":"en","primary_location":{"id":"pmid:23193897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali di igiene : medicina preventiva e di comunita","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/826497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077899672","display_name":"Marco Vinceti","orcid":"https://orcid.org/0000-0002-0551-2473","observed_orcids":["https://orcid.org/0000-0002-0551-2473"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Vinceti","raw_affiliation_strings":["Department of Diagnostic and Clinical Medicine and of Public Health, University of Modena and Reggio Emilia, Italy. marco.vinceti@unimore.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Clinical Medicine and of Public Health, University of Modena and Reggio Emilia, Italy. marco.vinceti@unimore.it","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085090777","display_name":"Maria Fiore","orcid":"https://orcid.org/0000-0002-7726-9329","observed_orcids":["https://orcid.org/0000-0002-7726-9329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fiore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071887801","display_name":"Carlo Signorelli","orcid":"https://orcid.org/0000-0002-0960-9563","observed_orcids":["https://orcid.org/0000-0002-0960-9563","https://orcid.org/0000-0001-9710-4962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Signorelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066610275","display_name":"Anna Odone","orcid":"https://orcid.org/0000-0002-5657-9774","observed_orcids":["https://orcid.org/0000-0002-5657-9774","https://orcid.org/0009-0007-4975-8188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Odone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081629642","display_name":"M. Tesauro","orcid":"https://orcid.org/0000-0001-5542-5119","observed_orcids":["https://orcid.org/0000-0001-5542-5119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tesauro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044878026","display_name":"Michela Consonni","orcid":"https://orcid.org/0000-0002-5078-0135","observed_orcids":["https://orcid.org/0000-0002-5078-0135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Consonni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010822465","display_name":"Elisa Arcolin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Arcolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024909354","display_name":"Carlotta Malagoli","orcid":"https://orcid.org/0000-0002-5085-347X","observed_orcids":["https://orcid.org/0000-0002-5085-347X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Malagoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053912816","display_name":"Jessica Mandrioli","orcid":"https://orcid.org/0000-0002-9244-9782","observed_orcids":["https://orcid.org/0000-0002-9244-9782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mandrioli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040860731","display_name":"Sandra Marmiroli","orcid":"https://orcid.org/0000-0001-5545-9319","observed_orcids":["https://orcid.org/0000-0001-5545-9319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Marmiroli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075012104","display_name":"Salvatore Sciacca","orcid":"https://orcid.org/0000-0002-8613-6296","observed_orcids":["https://orcid.org/0000-0002-8613-6296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sciacca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045431446","display_name":"Margherita Ferrante","orcid":"https://orcid.org/0000-0001-7596-2464","observed_orcids":["https://orcid.org/0000-0001-7596-2464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ferrante","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1931,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8596007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"5","first_page":"407","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/als-etiology","display_name":"ALS etiology","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pesticides","display_name":"pesticides","score":0.7839999794960022},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.9959999918937683},{"id":"https://openalex.org/keywords/magnetic-field","display_name":"magnetic field","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9670000076293945},{"id":"https://openalex.org/keywords/long-term-exposure","display_name":"long-term exposure","score":0.8920000195503235},{"id":"https://openalex.org/keywords/case-ascertainment","display_name":"case ascertainment","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cluster-detection","display_name":"cluster detection","score":0.8050000071525574},{"id":"https://openalex.org/keywords/environmental-modeling","display_name":"environmental modeling","score":0.890999972820282},{"id":"https://openalex.org/keywords/geographic-information-systems","display_name":"geographic information systems","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8473303318023682},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7334548234939575},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5814864635467529},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.48862677812576294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4829927682876587},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47536343336105347},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3195432424545288}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016021","descriptor_name":"Epidemiologic Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040362","descriptor_name":"Geographic Information Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:23193897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali di igiene : medicina preventiva e di comunita","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/826497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/826497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/71480","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/71480","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:177589616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/826497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/826497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W16380595","https://openalex.org/W55933825","https://openalex.org/W195246141","https://openalex.org/W1525270163","https://openalex.org/W1528026450","https://openalex.org/W1568390176","https://openalex.org/W1746080136","https://openalex.org/W1964591277","https://openalex.org/W1965638771","https://openalex.org/W1968192433","https://openalex.org/W1970761857","https://openalex.org/W1971131806","https://openalex.org/W1973825842","https://openalex.org/W1974001686","https://openalex.org/W1974448552","https://openalex.org/W1975445971","https://openalex.org/W1980935397","https://openalex.org/W1981483181","https://openalex.org/W1983633543","https://openalex.org/W1983787425","https://openalex.org/W1984486655","https://openalex.org/W1986655573","https://openalex.org/W1987626863","https://openalex.org/W1987784344","https://openalex.org/W1990787711","https://openalex.org/W1993012526","https://openalex.org/W1994306276","https://openalex.org/W2000661385","https://openalex.org/W2001432662","https://openalex.org/W2013154697","https://openalex.org/W2014433622","https://openalex.org/W2014599045","https://openalex.org/W2015387382","https://openalex.org/W2021322898","https://openalex.org/W2023260832","https://openalex.org/W2024150208","https://openalex.org/W2025651303","https://openalex.org/W2040355470","https://openalex.org/W2044638372","https://openalex.org/W2050628018","https://openalex.org/W2056010908","https://openalex.org/W2057207681","https://openalex.org/W2071991300","https://openalex.org/W2072164576","https://openalex.org/W2081434081","https://openalex.org/W2089090644","https://openalex.org/W2093926470","https://openalex.org/W2099027846","https://openalex.org/W2109001751","https://openalex.org/W2126792074","https://openalex.org/W2128739278","https://openalex.org/W2132186681","https://openalex.org/W2139373547","https://openalex.org/W2140755496","https://openalex.org/W2141225965","https://openalex.org/W2156003443","https://openalex.org/W2159546159","https://openalex.org/W2164678109","https://openalex.org/W2166447799","https://openalex.org/W2419339061","https://openalex.org/W2429692573","https://openalex.org/W2594198703","https://openalex.org/W2757083116","https://openalex.org/W4231363690"],"related_works":["https://openalex.org/W1528026450","https://openalex.org/W2269026804","https://openalex.org/W2407348554","https://openalex.org/W3020733395","https://openalex.org/W2166447799","https://openalex.org/W2014980242","https://openalex.org/W2074145008","https://openalex.org/W2031215528","https://openalex.org/W2805817972","https://openalex.org/W132134733"],"abstract_inverted_index":{"The":[0,89],"exact":[1],"role":[2,47],"of":[3,10,92,107,112,126],"environmental":[4,35,108],"risk":[5],"factors":[6,36,70],"in":[7,48,75],"the":[8,11,34,54,65,124,127],"etiology":[9,125],"neurodegenerative":[12],"disease":[13],"amyotrophic":[14],"lateral":[15],"sclerosis":[16],"(ALS)":[17],"is":[18],"still":[19],"unknown.":[20],"Their":[21],"hypothetical":[22],"contribution":[23],"ranges":[24],"from":[25],"a":[26,30,46],"minimal":[27],"impact":[28],"to":[29,44],"major":[31],"role.":[32],"Among":[33],"strictu":[37],"sensu":[38],"(i.e.,":[39],"not":[40],"life-style":[41],"factors)":[42],"suspected":[43],"play":[45],"ALS":[49,98],"etiology,":[50],"we":[51],"consider":[52],"pesticides,":[53],"metalloid":[55],"selenium,":[56],"some":[57],"heavy":[58],"metals,":[59],"magnetic":[60],"fields":[61],"and":[62,79,103,106,111],"cyanobacteria.":[63],"However,":[64],"possibility":[66],"exists":[67],"that":[68],"these":[69],"exert":[71],"their":[72],"activity":[73],"only":[74,80],"genetically":[76],"susceptible":[77],"persons":[78],"after":[81],"long-term":[82],"exposures,":[83],"thus":[84],"further":[85],"hampering":[86],"epidemiologic":[87],"studies.":[88],"recent":[90],"availability":[91],"powerful":[93],"tools":[94],"such":[95],"as":[96],"population-based":[97],"registries":[99],"for":[100,120],"case":[101],"ascertainment":[102],"clustering":[104],"detection,":[105],"modeling":[109],"techniques":[110],"geographical":[113],"information":[114],"systems,":[115],"may":[116],"yield":[117],"unique":[118],"opportunities":[119],"offering":[121],"insight":[122],"into":[123],"disease.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}