{"id":"https://openalex.org/W1775164443","doi":null,"title":"N-Myc induction stimulated by insulin-like growth factor I through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells.","display_name":"N-Myc induction stimulated by insulin-like growth factor I through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1775164443","mag":"1775164443","pmid":"https://pubmed.ncbi.nlm.nih.gov/10646854"},"language":"en","primary_location":{"id":"pmid:10646854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10646854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Misawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Misawa","raw_affiliation_strings":["Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020283","display_name":"Hajime Hosoi","orcid":"https://orcid.org/0000-0002-8345-0159","observed_orcids":["https://orcid.org/0000-0002-8345-0159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hosoi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Arimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Arimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000097559","display_name":"Takuma Shikata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shikata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063938062","display_name":"Shinji Akioka","orcid":"https://orcid.org/0000-0001-9017-3842","observed_orcids":["https://orcid.org/0000-0001-9017-3842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Akioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001986085","display_name":"Takafumi Matsumura","orcid":"https://orcid.org/0000-0002-0550-8589","observed_orcids":["https://orcid.org/0000-0002-0550-8589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Matsumura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Houghton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112548673","display_name":"Tamaki Sawada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sawada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3527,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.87622118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"60","issue":"1","first_page":"64","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.6940000057220459},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9829999804496765},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.7739999890327454},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase-1-2","display_name":"ERK1/ERK2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9380000233650208},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-progression","display_name":"G1/S cell cycle progression","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oncogene-expression-regulation","display_name":"oncogene expression regulation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7053667902946472},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5748718976974487},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5441312789916992},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5417836308479309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5198867321014404},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5128265023231506},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49188756942749023},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.48073863983154297},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.4758305847644806},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46498650312423706},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4443667531013489},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4388474225997925},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4110746383666992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40651682019233704},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38896092772483826},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3555373549461365},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3422339856624603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3192407786846161},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.31382790207862854},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2684272229671478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17393910884857178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060529500246047974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10646854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10646854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1775164443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10646854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5145123177","display_name":"Studies of Childhood Solid Tumors","funder_award_id":"P01CA023099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W47603266","https://openalex.org/W282758479","https://openalex.org/W1526707919","https://openalex.org/W1531521114","https://openalex.org/W1584184269","https://openalex.org/W1600272413","https://openalex.org/W1632492912","https://openalex.org/W1939283405","https://openalex.org/W1988014728","https://openalex.org/W1989480480","https://openalex.org/W1995563257","https://openalex.org/W2000082154","https://openalex.org/W2008550494","https://openalex.org/W2016252474","https://openalex.org/W2018744777","https://openalex.org/W2036614475","https://openalex.org/W2044033792","https://openalex.org/W2045919099","https://openalex.org/W2063361476","https://openalex.org/W2063647772","https://openalex.org/W2068502127","https://openalex.org/W2072476155","https://openalex.org/W2089305018","https://openalex.org/W2090407808","https://openalex.org/W2097731453","https://openalex.org/W2099896349","https://openalex.org/W2120191505","https://openalex.org/W2126560854","https://openalex.org/W2164051143","https://openalex.org/W2289990245","https://openalex.org/W2329408473","https://openalex.org/W2330923897"],"related_works":["https://openalex.org/W2302752396","https://openalex.org/W1600272413","https://openalex.org/W2416094556","https://openalex.org/W2044212828","https://openalex.org/W2010259934","https://openalex.org/W4298327952","https://openalex.org/W2002463596","https://openalex.org/W2074022052","https://openalex.org/W2027487939","https://openalex.org/W2148560290"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,32],"factor":[2],"I":[3,24],"(IGF-I)":[4],"stimulates":[5],"proliferation,":[6],"survival,":[7],"and":[8,73,112,121,131,154,162,182,194,221,229],"differentiation":[9],"in":[10,33,48,92,114,211],"many":[11],"cell":[12,198,215],"types,":[13],"including":[14],"pediatric":[15],"neuroblastomas.":[16,77],"The":[17,173],"effect":[18],"is":[19,29],"mediated":[20],"via":[21],"the":[22,49,55,115,126,171,212,218],"type":[23],"IGF-I":[25,86,108,140,151,208],"receptor":[26],"(IGF-IR),":[27],"which":[28],"essential":[30],"for":[31],"these":[34],"cells.":[35],"Several":[36],"lines":[37],"of":[38,51,54,60,76,81,90,119,139,156,187,231],"evidence":[39],"indicate":[40],"that":[41,101,107,207],"IGF-IR":[42,148],"function":[43],"may":[44],"be":[45,67],"particularly":[46],"important":[47],"pathogenesis":[50],"neuroblastoma.":[52],"Amplification":[53],"N-myc":[56,91,110],"oncogene":[57],"or":[58],"overexpression":[59],"N-Myc":[61,189,210,227],"oncoprotein":[62],"has":[63,102],"been":[64],"reported":[65],"to":[66,71,83],"associated":[68],"with":[69,117,164],"resistance":[70],"therapy":[72],"poor":[74],"prognosis":[75],"It":[78],"was":[79],"therefore":[80],"interest":[82],"analyze":[84],"whether":[85],"signaling":[87],"regulated":[88],"expression":[89],"KP-N-RT":[93,116,213],"human":[94],"neuroblastoma":[95,214],"cells":[96],"as":[97],"an":[98],"experimental":[99],"model":[100],"amplified":[103],"N-myc.":[104],"We":[105],"found":[106],"induces":[109,209],"mRNA":[111],"protein":[113],"maximums":[118],"four":[120],"six":[122],"times":[123],"more":[124],"than":[125],"basal":[127],"level":[128,167,220],"at":[129,217],"2":[130],"3":[132],"h":[133],"after":[134,170],"stimulation,":[135],"respectively.":[136],"These":[137],"effects":[138],"were":[141],"blocked":[142],"by":[143,202],"a":[144,165,184,223],"neutralizing":[145],"antibody":[146],"against":[147],"(alpha-IR3).":[149],"Exogenous":[150],"induced":[152],"phosphorylation":[153,181],"activation":[155,230],"extracellular":[157],"signal-regulated":[158],"kinases":[159],"p44/42":[160,179,232],"(ERK1":[161],"ERK2),":[163],"maximal":[166],"30":[168],"min":[169],"stimulation.":[172],"MEK1":[174],"inhibitor":[175],"PD98059":[176,195],"reduced":[177],"IGF-I-mediated":[178],"MAPKs":[180],"produced":[183],"parallel":[185],"reduction":[186],"IGF-I-stimulated":[188],"induction.":[190],"Furthermore,":[191],"both":[192],"alpha-IR3":[193],"inhibited":[196],"G1-S":[197],"cycle":[199],"progression":[200],"stimulated":[201],"IGF-I.":[203],"Our":[204],"results":[205],"demonstrate":[206],"line":[216],"RNA":[219],"establishes":[222],"clear":[224],"correlation":[225],"between":[226],"induction":[228],"MAPK":[233],"signaling.":[234]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
