{"id":"https://openalex.org/W177490605","doi":null,"title":"The effect of physical activity on the insulin response to frequent meals","display_name":"The effect of physical activity on the insulin response to frequent meals","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W177490605","mag":"177490605"},"language":"en","primary_location":{"id":"pmh:oai:surface.syr.edu:ppe_etd-1005","doi":null,"is_oa":true,"landing_page_url":"https://surface.syr.edu/ppe_etd/6","pdf_url":"https://surface.syr.edu/ppe_etd/6","source":{"id":"https://openalex.org/S4306401700","display_name":"Syracuse University Libraries (Syracuse University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70983195","host_organization_name":"Syracuse University","host_organization_lineage":["https://openalex.org/I70983195"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Exercise Science - Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://surface.syr.edu/ppe_etd/6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016195275","display_name":"Michael E. Holmstrup","orcid":"https://orcid.org/0000-0003-4669-5103","observed_orcids":["https://orcid.org/0000-0003-4669-5103"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael E. Holmstrup","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4669-5103","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016195275"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03194463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.953000009059906},{"id":"https://openalex.org/keywords/sedentary-behavior","display_name":"sedentary behavior","score":0.8360000252723694},{"id":"https://openalex.org/keywords/insulin-response","display_name":"insulin response","score":0.6949999928474426},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.800000011920929},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.972000002861023},{"id":"https://openalex.org/keywords/glycemic-excursions","display_name":"glycemic excursions","score":0.7699999809265137},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/insulin-pulsatility","display_name":"insulin pulsatility","score":0.7929999828338623},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.7739999890327454},{"id":"https://openalex.org/keywords/peptide-yy","display_name":"peptide YY","score":0.8659999966621399},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.9679999947547913},{"id":"https://openalex.org/keywords/intermittent-exercise","display_name":"intermittent exercise","score":0.9110000133514404},{"id":"https://openalex.org/keywords/continuous-exercise","display_name":"continuous exercise","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.5439302325248718},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44916966557502747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3549370765686035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2871396243572235},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.203039288520813}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:surface.syr.edu:ppe_etd-1005","doi":null,"is_oa":true,"landing_page_url":"https://surface.syr.edu/ppe_etd/6","pdf_url":"https://surface.syr.edu/ppe_etd/6","source":{"id":"https://openalex.org/S4306401700","display_name":"Syracuse University Libraries (Syracuse University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70983195","host_organization_name":"Syracuse University","host_organization_lineage":["https://openalex.org/I70983195"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Exercise Science - Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.942.1820","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.942.1820","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://surface.syr.edu/cgi/viewcontent.cgi?article%3D1005%26context%3Dppe_etd","raw_type":"text"},{"id":"mag:177490605","doi":null,"is_oa":false,"landing_page_url":"https://surface.syr.edu/cgi/viewcontent.cgi?article=1005&context=ppe_etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:surface.syr.edu:ppe_etd-1005","doi":null,"is_oa":true,"landing_page_url":"https://surface.syr.edu/ppe_etd/6","pdf_url":"https://surface.syr.edu/ppe_etd/6","source":{"id":"https://openalex.org/S4306401700","display_name":"Syracuse University Libraries (Syracuse University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70983195","host_organization_name":"Syracuse University","host_organization_lineage":["https://openalex.org/I70983195"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Exercise Science - Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W177490605.pdf","grobid_xml":"https://content.openalex.org/works/W177490605.grobid-xml"},"referenced_works_count":182,"referenced_works":["https://openalex.org/W18469072","https://openalex.org/W18996879","https://openalex.org/W106227524","https://openalex.org/W123699636","https://openalex.org/W178050794","https://openalex.org/W343035877","https://openalex.org/W1275630458","https://openalex.org/W1506981847","https://openalex.org/W1510737318","https://openalex.org/W1525324310","https://openalex.org/W1527613353","https://openalex.org/W1583635262","https://openalex.org/W1590146050","https://openalex.org/W1696182299","https://openalex.org/W1756507734","https://openalex.org/W1810683900","https://openalex.org/W1832609909","https://openalex.org/W1843479577","https://openalex.org/W1845821296","https://openalex.org/W1859968726","https://openalex.org/W1872744326","https://openalex.org/W1891017886","https://openalex.org/W1913527691","https://openalex.org/W1922850583","https://openalex.org/W1957255860","https://openalex.org/W1959810377","https://openalex.org/W1961812836","https://openalex.org/W1964227153","https://openalex.org/W1966467148","https://openalex.org/W1969480413","https://openalex.org/W1977140852","https://openalex.org/W1977152290","https://openalex.org/W1977270465","https://openalex.org/W1980164069","https://openalex.org/W1986939078","https://openalex.org/W1988243311","https://openalex.org/W1990060419","https://openalex.org/W1991060376","https://openalex.org/W1992268283","https://openalex.org/W1995825283","https://openalex.org/W2001044066","https://openalex.org/W2001369189","https://openalex.org/W2003005810","https://openalex.org/W2004091923","https://openalex.org/W2004584903","https://openalex.org/W2004762769","https://openalex.org/W2004994776","https://openalex.org/W2006441443","https://openalex.org/W2007175041","https://openalex.org/W2008108208","https://openalex.org/W2010639766","https://openalex.org/W2011571924","https://openalex.org/W2012615500","https://openalex.org/W2012692897","https://openalex.org/W2013496696","https://openalex.org/W2014970178","https://openalex.org/W2015301033","https://openalex.org/W2017993004","https://openalex.org/W2019129286","https://openalex.org/W2020439448","https://openalex.org/W2026459524","https://openalex.org/W2029520888","https://openalex.org/W2033631525","https://openalex.org/W2034114152","https://openalex.org/W2034735630","https://openalex.org/W2036961767","https://openalex.org/W2037339322","https://openalex.org/W2038623844","https://openalex.org/W2039424912","https://openalex.org/W2039931878","https://openalex.org/W2043093425","https://openalex.org/W2046166039","https://openalex.org/W2047195731","https://openalex.org/W2048186358","https://openalex.org/W2050025909","https://openalex.org/W2050675380","https://openalex.org/W2051087334","https://openalex.org/W2057154465","https://openalex.org/W2059047489","https://openalex.org/W2059927621","https://openalex.org/W2059954976","https://openalex.org/W2062547491","https://openalex.org/W2066210306","https://openalex.org/W2066991751","https://openalex.org/W2070268182","https://openalex.org/W2076213935","https://openalex.org/W2077553820","https://openalex.org/W2078854366","https://openalex.org/W2078862245","https://openalex.org/W2080513099","https://openalex.org/W2082796330","https://openalex.org/W2085416412","https://openalex.org/W2086825808","https://openalex.org/W2087121850","https://openalex.org/W2087194820","https://openalex.org/W2088719746","https://openalex.org/W2089149418","https://openalex.org/W2095070268","https://openalex.org/W2095152223","https://openalex.org/W2095485913","https://openalex.org/W2096038489","https://openalex.org/W2097315233","https://openalex.org/W2097701286","https://openalex.org/W2099652137","https://openalex.org/W2100697107","https://openalex.org/W2101035214","https://openalex.org/W2102848237","https://openalex.org/W2104898709","https://openalex.org/W2105262749","https://openalex.org/W2107300368","https://openalex.org/W2108735395","https://openalex.org/W2111541138","https://openalex.org/W2111914194","https://openalex.org/W2111923742","https://openalex.org/W2113180848","https://openalex.org/W2113436561","https://openalex.org/W2119264912","https://openalex.org/W2120414891","https://openalex.org/W2120932793","https://openalex.org/W2122360777","https://openalex.org/W2123970494","https://openalex.org/W2124360636","https://openalex.org/W2124568083","https://openalex.org/W2128004070","https://openalex.org/W2129074350","https://openalex.org/W2129213257","https://openalex.org/W2131377217","https://openalex.org/W2132613598","https://openalex.org/W2132928522","https://openalex.org/W2134227171","https://openalex.org/W2134556291","https://openalex.org/W2134832316","https://openalex.org/W2135326009","https://openalex.org/W2135697365","https://openalex.org/W2135773336","https://openalex.org/W2136548931","https://openalex.org/W2137217483","https://openalex.org/W2138660097","https://openalex.org/W2139973249","https://openalex.org/W2140473433","https://openalex.org/W2140955829","https://openalex.org/W2141029572","https://openalex.org/W2143931350","https://openalex.org/W2146581079","https://openalex.org/W2146980963","https://openalex.org/W2147610494","https://openalex.org/W2149914036","https://openalex.org/W2150314110","https://openalex.org/W2150933440","https://openalex.org/W2152238062","https://openalex.org/W2152582537","https://openalex.org/W2156340622","https://openalex.org/W2157002396","https://openalex.org/W2158822657","https://openalex.org/W2158951428","https://openalex.org/W2159896083","https://openalex.org/W2162427491","https://openalex.org/W2162523749","https://openalex.org/W2162726387","https://openalex.org/W2163886694","https://openalex.org/W2165666348","https://openalex.org/W2165768283","https://openalex.org/W2165860472","https://openalex.org/W2167438005","https://openalex.org/W2169558934","https://openalex.org/W2170277935","https://openalex.org/W2170772297","https://openalex.org/W2170819739","https://openalex.org/W2171397838","https://openalex.org/W2171440185","https://openalex.org/W2171999841","https://openalex.org/W2181090774","https://openalex.org/W2291769983","https://openalex.org/W2316416826","https://openalex.org/W2317654055","https://openalex.org/W2318584852","https://openalex.org/W2323205290","https://openalex.org/W2332951586","https://openalex.org/W2338075801","https://openalex.org/W2467500304","https://openalex.org/W3138780921","https://openalex.org/W4299417249"],"related_works":["https://openalex.org/W2055101537","https://openalex.org/W2896186241","https://openalex.org/W2530004154","https://openalex.org/W7097461996","https://openalex.org/W4224234767","https://openalex.org/W194283306","https://openalex.org/W2969270765","https://openalex.org/W3026190843","https://openalex.org/W3179556496","https://openalex.org/W4416425775"],"abstract_inverted_index":{"Long,":[0],"uninterrupted":[1],"bouts":[2,303],"of":[3,19,28,37,214,266,290,304,325,348],"sedentary":[4,82],"behavior":[5,83],"are":[6,341],"thought":[7],"to":[8,21,32,182,198,231,259,318,344],"negatively":[9],"influence":[10],"insulin":[11,56,140,151,191,220,267,315],"sensitivity,":[12],"and":[13,50,58,93,119,133,165,241,256,292,298,313,331],"may":[14],"impact":[15],"metabolic":[16],"function":[17],"regardless":[18],"adherence":[20],"general":[22],"physical":[23,38,94,305],"activity":[24,39,95,306],"guidelines.":[25],"The":[26,187],"purpose":[27],"this":[29],"study":[30,79,156,172],"was":[31,193,222,252],"determine":[33],"the":[34,48,122,178,183,217,225,239,260,308],"combined":[35],"effect":[36,213],"(1":[40],"h":[41,78,164,189,219,249,324],"continuous":[42,297,330],"exercise":[43,46,85,320,333],"v.":[44,201],"intermittent":[45,299,332],"throughout":[47,307],"day)":[49],"meal":[51],"consumption":[52],"on":[53],"glucose":[54,311],"excursions,":[55],"secretion,":[57],"appetite":[59,135],"markers":[60],"in":[61,148,177,216,247,281,338,346],"obese":[62,69,339],"individuals":[63,340],"with":[64,73,174,224,254,296,322],"prediabetes.":[65],"Methods:":[66],"Eleven":[67],"healthy,":[68],"subjects":[70],"(>30":[71],"kg/m2)":[72],"prediabetes":[74],"underwent":[75],"3,":[76],"12":[77,97,116,188,205],"days":[80,157],"including":[81],"(SED),":[84],"(EX;":[86],"1h":[87],"morning":[88,326],"exercise,":[89],"60-65%":[90],"VO2":[91],"max),":[92],"(PA;":[96],"hourly,":[98],"intensity-matched":[99],"5-minute":[100],"bouts).":[101],"Meals":[102],"were":[103,110,142,158,168,277,294],"provided":[104],"every":[105,112],"2":[106,166,218,248],"h.":[107,117],"Blood":[108],"samples":[109],"taken":[111],"10":[113],"min":[114],"for":[115,125,204],"Baseline":[118],"area":[120],"under":[121],"curve":[123],"(AUC)":[124],"serum":[126],"glucose,":[127,150],"insulin,":[128],"c-peptide,":[129],"total":[130,282],"PYY":[131,283],"concentrations,":[132],"subjective":[134,288],"ratings;":[136],"as":[137,139],"well":[138],"pulsatility":[141],"determined.":[143],"Results:":[144],"No":[145],"significant":[146,211,245,271,279],"differences":[147,237,272,280],"baseline":[149],"or":[152],"c-peptide":[153,250],"concentrations":[154,347],"across":[155,171],"observed":[159],"(P>0.05).":[160],"Glucose":[161],"AUC":[162,175,192,221,251],"(12":[163],"h)":[167],"significantly":[169],"different":[170],"days,":[173],"attenuated":[176],"PA":[179,196,226,257],"condition":[180,185,215,227,233,262],"compared":[181,197,230,258,317],"EX":[184,240,255],"(P<0.05).":[186,263],"incremental":[190],"reduced":[194,229,295],"by":[195],"SED":[199,232,242,261],"(173,985\u00b13556.8":[200],"227,352\u00b14581.2":[202],"pmol/L*min":[203],"h,":[206],"respectively;":[207],"P<0.05).":[208],"Similarly,":[209],"a":[210],"main":[212],"found,":[223],"being":[228],"(P<0.05),":[234],"but":[235],"no":[236,270,278],"between":[238,273,284],"conditions.":[243,275],"A":[244],"reduction":[246],"demonstrated":[253],"Deconvolution":[264],"analysis":[265],"secretion":[268],"revealed":[269],"experimental":[274,285],"There":[276],"conditions,":[286],"though":[287],"measures":[289],"hunger":[291],"satiety":[293,337],"exercise.":[300,327],"Conclusions:":[301],"Short":[302],"day":[309,321],"attenuate":[310],"excursions":[312],"improve":[314,336],"clearance":[316],"an":[319],"1":[323],"Further,":[328],"both":[329],"mechanisms":[334],"that":[335],"not":[342],"related":[343],"changes":[345],"PYY.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}