{"id":"https://openalex.org/W1773548472","doi":"https://doi.org/10.1242/dev.126391","title":"Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway","display_name":"Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1773548472","doi":"https://doi.org/10.1242/dev.126391","mag":"1773548472","pmid":"https://pubmed.ncbi.nlm.nih.gov/26160899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550968"},"language":"en","primary_location":{"id":"doi:10.1242/dev.126391","doi":"https://doi.org/10.1242/dev.126391","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.126391","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550968","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101909762","display_name":"Jianxin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianxin Hu","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037665705","display_name":"Michael Paul Verzi","orcid":"https://orcid.org/0000-0003-4082-4330","observed_orcids":["https://orcid.org/0000-0003-4082-4330"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Verzi","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056132123","display_name":"Ashley S. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley S. Robinson","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027536358","display_name":"Paul Ling-Fung Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Ling-Fung Tang","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006917864","display_name":"Lisa L. Hua","orcid":"https://orcid.org/0009-0008-2975-2384","observed_orcids":["https://orcid.org/0009-0008-2975-2384"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa L. Hua","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103370155","display_name":"Shan-Mei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan-Mei Xu","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022617562","display_name":"Pui\u2013Yan Kwok","orcid":"https://orcid.org/0000-0002-5087-3059","observed_orcids":["https://orcid.org/0000-0002-5087-3059"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pui-Yan Kwok","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Department of Dermatology, University of California, San Francisco, CA 94143, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Dermatology, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064800933","display_name":"Brian L. Black","orcid":"https://orcid.org/0000-0002-6664-8913","observed_orcids":["https://orcid.org/0000-0002-6664-8913"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian L. Black","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA","Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064800933"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":1.2973,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.78305367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"142","issue":"16","first_page":"2775","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-signaling","display_name":"endothelin signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mef2c","display_name":"MEF2C","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neural-crest-development","display_name":"neural crest development","score":0.9369999766349792},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.7760000228881836},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.6710000038146973},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.6890000104904175},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.8920000195503235},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mads-box-transcription-factors","display_name":"MADS-box transcription factors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/waardenburg-syndrome","display_name":"Waardenburg syndrome","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C146291010","wikidata":"https://www.wikidata.org/wiki/Q18029008","display_name":"MEF2C","level":4,"score":0.9412829875946045},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.8773841857910156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7927613258361816},{"id":"https://openalex.org/C51183755","wikidata":"https://www.wikidata.org/wiki/Q83166919","display_name":"Mef2","level":5,"score":0.7828863859176636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5864957571029663},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5303469300270081},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.508574366569519},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4941997826099396},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.4670509397983551},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3085116147994995},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064326","descriptor_name":"MEF2 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1242/dev.126391","doi":"https://doi.org/10.1242/dev.126391","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.126391","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3944799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4550968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550968","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:26160899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26160899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3944799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4550968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6319980339","display_name":"Transcriptional Networks During Cardiac Differentiation","funder_award_id":"P01HL089707","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6740693088","display_name":"Regulation of cardiovascular transcription","funder_award_id":"R01HL064658","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7763323533","display_name":"Molecular and Genetic Regulation of Craniofacial Development","funder_award_id":"R01DE019118","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1502227906","https://openalex.org/W1585473102","https://openalex.org/W1900565974","https://openalex.org/W1971977081","https://openalex.org/W1972509561","https://openalex.org/W1977819697","https://openalex.org/W2004292360","https://openalex.org/W2011182719","https://openalex.org/W2028452724","https://openalex.org/W2029274317","https://openalex.org/W2037381436","https://openalex.org/W2043604666","https://openalex.org/W2070437897","https://openalex.org/W2084097609","https://openalex.org/W2086408506","https://openalex.org/W2097672164","https://openalex.org/W2103721311","https://openalex.org/W2104010513","https://openalex.org/W2109418446","https://openalex.org/W2116631863","https://openalex.org/W2121699212","https://openalex.org/W2125216530","https://openalex.org/W2130604047","https://openalex.org/W2143242950","https://openalex.org/W2161322544","https://openalex.org/W2162804111","https://openalex.org/W2169325319","https://openalex.org/W2170039745","https://openalex.org/W2240281720","https://openalex.org/W2482023686"],"related_works":["https://openalex.org/W4389560905","https://openalex.org/W2097672164","https://openalex.org/W147163756","https://openalex.org/W2128852575","https://openalex.org/W2064222189","https://openalex.org/W2086408506","https://openalex.org/W2949136909","https://openalex.org/W2045581442","https://openalex.org/W2064726461","https://openalex.org/W2034680574"],"abstract_inverted_index":{"Endothelin":[0,10,44,72,81,113,122,149,162],"signaling":[1,11,45,73,82,123,138,163],"is":[2,12,63],"essential":[3],"for":[4,148],"neural":[5,16,33,47,76,88,105,125,166],"crest":[6,34,48,89,106,126],"development,":[7],"and":[8,21,36,69,98,151,159],"dysregulated":[9],"associated":[13],"with":[14],"several":[15],"crest-related":[17],"disorders,":[18],"including":[19],"Waardenburg":[20],"other":[22],"syndromes.":[23],"However,":[24],"despite":[25],"the":[26,38,57,75,87,95,109,165],"crucial":[27],"roles":[28],"of":[29,71,102,115,128,161],"this":[30,103],"pathway":[31],"in":[32,74,86,94,164],"development":[35,49],"disease,":[37],"transcriptional":[39,67,157],"effectors":[40],"directly":[41],"activated":[42],"by":[43,130],"during":[46],"remain":[50],"incompletely":[51],"elucidated.":[52],"Here,":[53],"we":[54,119],"establish":[55,152],"that":[56,80,99,121],"MADS":[58],"box":[59],"transcription":[60],"factor":[61],"MEF2C":[62,132,153],"an":[64,155],"immediate":[65,156],"downstream":[66],"target":[68,160],"effector":[70,158],"crest.":[77,167],"We":[78],"show":[79],"activates":[83,124],"Mef2c":[84,96,104,116,129],"expression":[85,127],"through":[90,134],"a":[91,135,144],"conserved":[92],"enhancer":[93,107],"locus":[97],"CRISPR-mediated":[100],"deletion":[101],"from":[108],"mouse":[110],"genome":[111],"abolishes":[112],"induction":[114,150],"expression.":[117],"Moreover,":[118],"demonstrate":[120],"de-repressing":[131],"activity":[133],"Calmodulin-CamKII-histone":[136],"deacetylase":[137],"cascade.":[139],"Thus,":[140],"these":[141],"findings":[142],"identify":[143],"MEF2C-dependent,":[145],"positive-feedback":[146],"mechanism":[147],"as":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}