{"id":"https://openalex.org/W177317466","doi":"https://doi.org/10.3969/j.issn.1672-7347.2011.10.001","title":"Research progress in the organic cation transporters.","display_name":"Research progress in the organic cation transporters.","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W177317466","doi":"https://doi.org/10.3969/j.issn.1672-7347.2011.10.001","mag":"177317466","pmid":"https://pubmed.ncbi.nlm.nih.gov/22086000"},"language":"en","primary_location":{"id":"pmid:22086000","doi":"https://doi.org/10.3969/j.issn.1672-7347.2011.10.001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22086000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065113416","display_name":"Yan Shu","orcid":"https://orcid.org/0000-0001-8492-1437","observed_orcids":["https://orcid.org/0000-0001-8492-1437"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yan Shu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland, Baltimore MD 21201,USA. yshu@rx.umaryland.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland, Baltimore MD 21201,USA. yshu@rx.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065113416"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":0.4916,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66464198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"10","first_page":"913","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organic-cation-transporters","display_name":"organic cation transporters","score":1.0},{"id":"https://openalex.org/keywords/tubular-secretion","display_name":"renal tubular secretion","score":0.6079999804496765},{"id":"https://openalex.org/keywords/solute-carriers","display_name":"solute carrier transporters","score":0.5849999785423279},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.7400000095367432},{"id":"https://openalex.org/keywords/transport-mechanisms","display_name":"transport mechanisms","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6209999918937683},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.949999988079071},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5550000071525574},{"id":"https://openalex.org/keywords/intestine","display_name":"intestine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/genetic-animal-models","display_name":"genetic animal models","score":0.828000009059906},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.8593016862869263},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.682968258857727},{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.5996071696281433},{"id":"https://openalex.org/C121421483","wikidata":"https://www.wikidata.org/wiki/Q43457632","display_name":"Organic anion","level":3,"score":0.5419098138809204},{"id":"https://openalex.org/C168785527","wikidata":"https://www.wikidata.org/wiki/Q1401099","display_name":"Solute carrier family","level":4,"score":0.5314024686813354},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5046526193618774},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.43742334842681885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43074870109558105},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42536020278930664},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.41053009033203125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39997321367263794},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36413872241973877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34558480978012085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2798294723033905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1628628671169281},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.15113478899002075},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22086000","doi":"https://doi.org/10.3969/j.issn.1672-7347.2011.10.001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22086000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","raw_type":"Journal Article"},{"id":"mag:177317466","doi":"https://doi.org/10.3969/j.issn.1672-7347.2011.10.001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22086000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1602209743","https://openalex.org/W2100713850","https://openalex.org/W2059781478","https://openalex.org/W2952528625","https://openalex.org/W2756225471","https://openalex.org/W2410181093","https://openalex.org/W2994850615","https://openalex.org/W4366242336","https://openalex.org/W3094486787","https://openalex.org/W2379953042"],"abstract_inverted_index":{"The":[0,61],"organic":[1,43,62,82,123,196],"cation":[2,63,83,124],"transport":[3,64,125,184],"systems":[4,65],"were":[5],"initially":[6],"recognized":[7,71],"in":[8,66,90,97,101,131,138,219,228],"studies":[9],"of":[10,15,110,122,152,159,163,177,193,217],"renal":[11],"elimination.":[12],"A":[13],"variety":[14],"endogenous":[16],"and":[17,54,100,113,142,150,175,188,190,200,232],"exogenous":[18],"compounds":[19,40],"that":[20,45],"are":[21,26,41],"harmful":[22],"to":[23,50],"the":[24,29,59,67,76,80,95,98,102,116,120,147,172,210],"body":[25],"eliminated":[27],"from":[28,79],"kidney":[30,68],"via":[31],"glomerular":[32],"filtration":[33],"and/or":[34],"active":[35],"tubular":[36],"secretion.":[37],"Among":[38],"those":[39],"polar":[42],"cations":[44],"require":[46],"a":[47],"transporter-mediated":[48],"process":[49],"cross":[51],"cellular":[52],"membrane":[53],"be":[55,205],"eventually":[56],"excreted":[57],"into":[58],"urine.":[60],"have":[69,86,104,126,154],"been":[70,88,105,127],"for":[72],"several":[73,118],"decades.":[74],"Following":[75],"insight":[77,213],"gained":[78],"kidney,":[81],"transporters":[84,218],"(OCTs)":[85],"also":[87],"characterized":[89,129],"other":[91],"tissues.":[92],"In":[93,145,166],"particular,":[94,146],"OCTs":[96,153],"liver":[99],"intestine":[103],"proposed":[106],"as":[107,207],"important":[108,161,212,238],"determinants":[109],"drug":[111],"absorption":[112],"disposition.":[114],"Over":[115],"past":[117],"decades,":[119],"mechanisms":[121,199],"extensively":[128],"using":[130],"vivo":[132,135],"models,":[133],"ex":[134],"organ":[136],"perfusions,":[137],"vitro":[139],"tissue":[140,186],"preparations":[141],"cell":[143],"lines.":[144],"molecular":[148,173],"cloning":[149,174],"characterization":[151,176],"remarkably":[155],"increased":[156],"our":[157],"knowledge":[158],"this":[160,167,215],"subfamily":[162],"solute":[164],"carriers.":[165],"article,":[168],"we":[169,223],"first":[170],"review":[171],"OCTs.":[178],"We":[179],"will":[180,204,224],"then":[181],"describe":[182],"their":[183,191],"mechanisms,":[185],"distribution":[187],"localization,":[189],"specificity":[192],"interaction":[194],"with":[195],"cations.":[197],"Regulatory":[198],"genetic":[201,226],"animal":[202],"models":[203],"reviewed":[206],"they":[208],"provide":[209],"most":[211],"on":[214,236],"class":[216],"recent":[220],"years.":[221],"Finally,":[222],"summarize":[225],"variation":[227],"human":[229],"OCT":[230],"genes":[231],"raise":[233],"clinical":[234],"perspectives":[235],"these":[237],"transporters.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
