{"id":"https://openalex.org/W177283308","doi":"https://doi.org/10.2172/836260","title":"Monitoring Gene Expression In Vivo with Nucleic Acid Molecular Switches","display_name":"Monitoring Gene Expression In Vivo with Nucleic Acid Molecular Switches","publication_year":2005,"publication_date":"2005-01-26","ids":{"openalex":"https://openalex.org/W177283308","doi":"https://doi.org/10.2172/836260","mag":"177283308"},"language":"en","primary_location":{"id":"doi:10.2172/836260","doi":"https://doi.org/10.2172/836260","is_oa":false,"landing_page_url":"https://doi.org/10.2172/836260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chicago Operations Office","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/biblio/836260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102984796","display_name":"David C. Ward","orcid":"https://orcid.org/0000-0003-2380-4813","observed_orcids":["https://orcid.org/0000-0003-2380-4813","https://orcid.org/0000-0002-2705-408X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111618522","display_name":"Patricia Bray\u2010Ward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Bray-Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-ribozymes","display_name":"allosteric ribozymes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mrna-profiling","display_name":"mRNA expression profiling","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.7222793102264404},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5717939138412476},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5596515536308289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47790464758872986},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4390747845172882},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4174959659576416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3616023063659668},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2872665226459503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2469967007637024}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2172/836260","doi":"https://doi.org/10.2172/836260","is_oa":false,"landing_page_url":"https://doi.org/10.2172/836260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chicago Operations Office","raw_type":"report"},{"id":"pmh:info:ark/67531/metadc788646","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc788646/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Report"},{"id":"pmh:oai:osti.gov:836260","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/836260","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:836260","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/836260","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015960673","https://openalex.org/W2605049302","https://openalex.org/W2907612941","https://openalex.org/W2034328637","https://openalex.org/W7028249675","https://openalex.org/W2134097743","https://openalex.org/W2792540998","https://openalex.org/W1973601455","https://openalex.org/W2072917294","https://openalex.org/W4237600044"],"abstract_inverted_index":{"The":[0],"overall":[1],"objectives":[2],"of":[3,13,22,58,63,95,105,132,138],"this":[4,136],"project":[5,126],"were":[6],"(1)":[7],"to":[8,37,42,81,128,155],"develop":[9,38],"allosteric":[10],"ribozymes":[11],"capable":[12],"acting":[14],"as":[15],"molecular":[16,46,107,119],"switches":[17,47],"for":[18],"monitoring":[19],"the":[20,55,73,85,100,106,115,139,145,149,167],"levels":[21],"both":[23],"wild-type":[24],"and":[25,32,35,52,83,92,102,152],"mutant":[26],"mRNA":[27],"species":[28],"in":[29,70,84,158],"living":[30,49,159],"cells":[31],"whole":[33],"animals":[34,53],"(2)":[36],"highly":[39],"efficient":[40],"reagents":[41,151],"deliver":[43],"nucleic":[44],"acid":[45],"into":[48],"cells,":[50,160],"tissues":[51],"with":[54],"ultimate":[56],"goal":[57],"expression":[59],"profiling":[60],"specific":[61],"mRNAs":[62],"diagnostic":[64],"or":[65],"prognostic":[66],"value":[67],"within":[68],"tumors":[69],"animals.":[71],"During":[72],"past":[74,125],"year,":[75],"we":[76,88,121,142],"have":[77,89],"moved":[78],"our":[79,133],"laboratory":[80],"Nevada":[82],"moving":[86],"process":[87],"lost":[90],"electronic":[91],"paper":[93],"copies":[94],"prior":[96],"progress":[97,113],"reports":[98,127],"concerning":[99],"construction":[101],"biological":[103],"properties":[104],"switches.":[108],"Since":[109],"there":[110],"was":[111],"minimal":[112],"during":[114,166],"last":[116],"year":[117],"on":[118,124,135,148],"switches,":[120],"are":[122,143],"relying":[123],"provide":[129],"a":[130],"summary":[131],"data":[134],"facet":[137],"grant.":[140],"Here":[141],"summarizing":[144],"work":[146,164],"done":[147,165],"delivery":[150],"their":[153],"application":[154],"inducing":[156],"mutations":[157],"which":[161],"will":[162],"include":[163],"no":[168],"cost":[169],"extension.":[170]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
