{"id":"https://openalex.org/W1771384872","doi":null,"title":"Amelioration of oxidative stress in human endothelial cells by caffeic acid phenethyl ester (CAPE) and fluorinated derivatives (FCAPES) and pharmacokinetic characterization of CAPE and FCAPE in rats","display_name":"Amelioration of oxidative stress in human endothelial cells by caffeic acid phenethyl ester (CAPE) and fluorinated derivatives (FCAPES) and pharmacokinetic characterization of CAPE and FCAPE in rats","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W1771384872","mag":"1771384872"},"language":"en","primary_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3716","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3716","pdf_url":"http://hdl.handle.net/2152/3716","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2152/3716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100352820","display_name":"Xinyu Wang","orcid":"https://orcid.org/0000-0002-9167-2077","observed_orcids":["https://orcid.org/0000-0002-9167-2077","https://orcid.org/0009-0000-4288-8421","https://orcid.org/0000-0002-8435-8135"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xinyu Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9167-2077","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100352820"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9369999766349792},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8659999966621399},{"id":"https://openalex.org/keywords/plasma-stability","display_name":"plasma stability","score":0.7829999923706055},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/uplc-ms-ms-quantification","display_name":"UPLC-MS/MS quantification","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2776992468","wikidata":"https://www.wikidata.org/wiki/Q15410860","display_name":"Caffeic acid phenethyl ester","level":4,"score":0.9946267008781433},{"id":"https://openalex.org/C2777628658","wikidata":"https://www.wikidata.org/wiki/Q1034198","display_name":"Cape","level":2,"score":0.6660699248313904},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6511926651000977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4580825865268707},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.455809086561203},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.42425522208213806},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35994619131088257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31431296467781067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2887365221977234},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.24150040745735168},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0739641785621643},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3716","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3716","pdf_url":"http://hdl.handle.net/2152/3716","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1771384872","doi":null,"is_oa":false,"landing_page_url":"https://repositories.lib.utexas.edu/bitstream/2152/3716/2/wangx59618.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3716","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3716","pdf_url":"http://hdl.handle.net/2152/3716","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1771384872.pdf","grobid_xml":"https://content.openalex.org/works/W1771384872.grobid-xml"},"referenced_works_count":180,"referenced_works":["https://openalex.org/W148156359","https://openalex.org/W1211777005","https://openalex.org/W1501532586","https://openalex.org/W1538826970","https://openalex.org/W1539606768","https://openalex.org/W1551093971","https://openalex.org/W1556563652","https://openalex.org/W1563843074","https://openalex.org/W1569643828","https://openalex.org/W1621595817","https://openalex.org/W1655162787","https://openalex.org/W1848232804","https://openalex.org/W1871287341","https://openalex.org/W1914622032","https://openalex.org/W1933674778","https://openalex.org/W1964212038","https://openalex.org/W1965693998","https://openalex.org/W1966111215","https://openalex.org/W1966582616","https://openalex.org/W1966630112","https://openalex.org/W1966703352","https://openalex.org/W1967579132","https://openalex.org/W1967807748","https://openalex.org/W1971542979","https://openalex.org/W1972442898","https://openalex.org/W1978168286","https://openalex.org/W1978272694","https://openalex.org/W1981646154","https://openalex.org/W1983994045","https://openalex.org/W1984642803","https://openalex.org/W1985842200","https://openalex.org/W1986251296","https://openalex.org/W1986985508","https://openalex.org/W1987460347","https://openalex.org/W1987777210","https://openalex.org/W1988813908","https://openalex.org/W1990756467","https://openalex.org/W1991303210","https://openalex.org/W1992136740","https://openalex.org/W1994496450","https://openalex.org/W1995625289","https://openalex.org/W1995910926","https://openalex.org/W1998784580","https://openalex.org/W1999301504","https://openalex.org/W1999432079","https://openalex.org/W2001019228","https://openalex.org/W2001244628","https://openalex.org/W2003292735","https://openalex.org/W2004725801","https://openalex.org/W2005904261","https://openalex.org/W2007161289","https://openalex.org/W2007348887","https://openalex.org/W2008892452","https://openalex.org/W2009573767","https://openalex.org/W2010185799","https://openalex.org/W2011085845","https://openalex.org/W2011871889","https://openalex.org/W2012667867","https://openalex.org/W2015034554","https://openalex.org/W2019860345","https://openalex.org/W2019872811","https://openalex.org/W2020861617","https://openalex.org/W2022776454","https://openalex.org/W2023397305","https://openalex.org/W2024560631","https://openalex.org/W2027411662","https://openalex.org/W2028778467","https://openalex.org/W2030429605","https://openalex.org/W2031836453","https://openalex.org/W2032662949","https://openalex.org/W2033629148","https://openalex.org/W2033914311","https://openalex.org/W2034532845","https://openalex.org/W2035088045","https://openalex.org/W2035529274","https://openalex.org/W2036174238","https://openalex.org/W2036313803","https://openalex.org/W2037078665","https://openalex.org/W2038370254","https://openalex.org/W2038459965","https://openalex.org/W2040365742","https://openalex.org/W2041088774","https://openalex.org/W2041553103","https://openalex.org/W2042899073","https://openalex.org/W2043598314","https://openalex.org/W2045023739","https://openalex.org/W2045197265","https://openalex.org/W2046265824","https://openalex.org/W2048487276","https://openalex.org/W2049561349","https://openalex.org/W2052637380","https://openalex.org/W2054724205","https://openalex.org/W2055140428","https://openalex.org/W2055211611","https://openalex.org/W2055340962","https://openalex.org/W2058535415","https://openalex.org/W2060320036","https://openalex.org/W2060662813","https://openalex.org/W2061957367","https://openalex.org/W2062728133","https://openalex.org/W2064640025","https://openalex.org/W2064691836","https://openalex.org/W2064846343","https://openalex.org/W2066668553","https://openalex.org/W2067479751","https://openalex.org/W2067714284","https://openalex.org/W2068611508","https://openalex.org/W2069331552","https://openalex.org/W2069363861","https://openalex.org/W2069420389","https://openalex.org/W2070297535","https://openalex.org/W2071219983","https://openalex.org/W2072232906","https://openalex.org/W2073679813","https://openalex.org/W2075564007","https://openalex.org/W2078507610","https://openalex.org/W2078696617","https://openalex.org/W2080913298","https://openalex.org/W2081519860","https://openalex.org/W2084204140","https://openalex.org/W2084419709","https://openalex.org/W2084708456","https://openalex.org/W2085304303","https://openalex.org/W2086221356","https://openalex.org/W2086246413","https://openalex.org/W2093140151","https://openalex.org/W2094783740","https://openalex.org/W2094866111","https://openalex.org/W2096037514","https://openalex.org/W2096528913","https://openalex.org/W2096576358","https://openalex.org/W2097744068","https://openalex.org/W2101464901","https://openalex.org/W2101707809","https://openalex.org/W2106196860","https://openalex.org/W2106835194","https://openalex.org/W2111232772","https://openalex.org/W2113225624","https://openalex.org/W2114893973","https://openalex.org/W2115485369","https://openalex.org/W2116037211","https://openalex.org/W2116770715","https://openalex.org/W2117752737","https://openalex.org/W2117934439","https://openalex.org/W2120505405","https://openalex.org/W2124122523","https://openalex.org/W2125762200","https://openalex.org/W2130345110","https://openalex.org/W2132552227","https://openalex.org/W2132608478","https://openalex.org/W2133662318","https://openalex.org/W2137645566","https://openalex.org/W2137962262","https://openalex.org/W2139967865","https://openalex.org/W2140230248","https://openalex.org/W2144785467","https://openalex.org/W2145530136","https://openalex.org/W2146572998","https://openalex.org/W2147763100","https://openalex.org/W2149458669","https://openalex.org/W2152907187","https://openalex.org/W2157488207","https://openalex.org/W2159336659","https://openalex.org/W2159611626","https://openalex.org/W2162262399","https://openalex.org/W2162713311","https://openalex.org/W2163957182","https://openalex.org/W2164631866","https://openalex.org/W2166127265","https://openalex.org/W2166803343","https://openalex.org/W2166856053","https://openalex.org/W2169161738","https://openalex.org/W2170098987","https://openalex.org/W2256565529","https://openalex.org/W2314054150","https://openalex.org/W2318058691","https://openalex.org/W2410537909","https://openalex.org/W2413334023","https://openalex.org/W2951167148","https://openalex.org/W4406054934"],"related_works":["https://openalex.org/W2052179261","https://openalex.org/W2053344641","https://openalex.org/W2300445976","https://openalex.org/W2180116694","https://openalex.org/W2019705657","https://openalex.org/W4310744606","https://openalex.org/W2136363332","https://openalex.org/W4389023804","https://openalex.org/W2161983562","https://openalex.org/W1980387354"],"abstract_inverted_index":{"Tissue":[0],"ischemia":[1],"is":[2,97],"a":[3,46,117,152],"major":[4],"cause":[5],"of":[6,52,85,94,100,149,184,192,199,204,232,246,249,255,308,326,380,392],"morbidity":[7],"contributing":[8],"to":[9,24,27,31,42,54,76,125,140,162,189,261,264,284,363,387],"disease":[10],"processes":[11],"such":[12],"as":[13],"cardiovascular":[14],"diseases,":[15],"stroke,":[16],"cancer,":[17],"and":[18,21,74,81,134,206,219,234,237,257,310,329,333,369,382],"traumatic":[19],"injury":[20,61,96,165],"may":[22,108,385],"lead":[23],"death.":[25,37],"Failure":[26],"quickly":[28],"reestablish":[29],"flow":[30,44],"ischemic":[32,55],"tissue":[33,36,56],"results":[34,57,340],"in":[35,48,58,132,158,166,221,267,286,291,312,317,350,390],"However,":[38],"even":[39],"timely":[40],"return":[41],"normal":[43],"has":[45,122,137,186],"downside":[47],"that":[49,62,252,304,342],"the":[50,78,86,92,98,101,147,197,201,222,247,351,356,376,388],"reintroduction":[51],"oxygen":[53,103],"ischemia/reperfusion":[59],"(I/R)":[60],"produces":[63],"an":[64],"oxidant":[65],"stress.":[66],"This":[67],"pathological":[68],"process":[69],"requires":[70],"new":[71,212],"therapeutic":[72],"strategies":[73],"agents":[75],"reduce":[77],"personal,":[79],"social":[80],"economic":[82],"loss.":[83],"One":[84,276],"most":[87],"generally":[88],"accepted":[89],"mechanisms":[90],"for":[91,242,306,345],"pathology":[93],"I/R":[95,110,129,164],"production":[99],"reactive":[102],"species":[104],"(ROS),":[105],"suggesting":[106],"antioxidants":[107],"ameliorate":[109],"injury.":[111],"Caffeic":[112],"acid":[113],"phenethyl":[114],"ester":[115],"(CAPE),":[116],"plant":[118],"derived":[119],"polyphenolic":[120],"compound,":[121],"been":[123,138,187],"shown":[124],"protect":[126],"organs":[127],"from":[128],"induced":[130],"damage":[131],"vivo,":[133],"this":[135],"effect":[136,203],"attributed":[139],"its":[141,190],"antioxidant":[142],"activity.":[143,275],"To":[144],"better":[145,260,289],"understand":[146],"mechanism":[148,248],"CAPE":[150,185,205,215,233,256,277,285,309,332,346,368,383],"protection,":[151],"model":[153],"using":[154],"menadione-induced":[155],"oxidative":[156],"stress":[157],"human":[159,268],"endothelial":[160,269],"cells":[161,270],"simulate":[163],"vitro":[167,287],"was":[168,173,302,360,373],"developed.":[169],"Gene":[170],"expression":[171],"analysis":[172],"performed":[174],"with":[175,179,280],"microarrays":[176],"undergoing":[177],"cytoprotection":[178,183,250,253],"CAPE.":[180],"The":[181,226,339],"dose-dependent":[182],"related":[188],"induction":[191],"heme":[193],"oxygenase-1":[194],"(HO-1).":[195],"With":[196],"aim":[198],"improving":[200],"beneficial":[202],"understanding":[207],"structure":[208],"activity":[209],"relationship,":[210],"six":[211],"catechol":[213],"ring-fluorinated":[214],"derivatives":[216,258],"were":[217,337],"synthesized":[218],"evaluated":[220],"menadione-endothelial":[223],"cell":[224],"model.":[225],"data":[227],"suggest":[228],"good":[229],"cytoprotective":[230,281],"effects":[231,282],"some":[235],"analogues":[236],"indicate":[238,341],"important":[239],"structural":[240],"features":[241],"cytoprotection.":[243],"Further":[244],"investigation":[245],"showed":[251],"profiles":[254],"correlate":[259],"their":[262],"ability":[263],"induce":[265],"HO-1":[266],"than":[271],"free":[272],"radical":[273],"scavenging":[274],"derivative":[278],"(FCAPE)":[279],"similar":[283],"exhibited":[288],"stability":[290],"rat":[292],"plasma.":[293],"A":[294],"validated":[295],"ultra-performance":[296],"liquid":[297],"chromatography/tandem":[298],"mass":[299],"spectrometric":[300],"method":[301],"developed":[303],"allowed":[305],"quantification":[307],"FCAPE":[311,336,381],"plasma":[313],"samples.":[314],"Pharmacokinetic":[315],"studies":[316],"male":[318],"Sprague":[319],"Dawley":[320],"rats":[321],"following":[322],"intravenous":[323],"bolus":[324],"administration":[325],"5,":[327],"10,":[328],"20":[330,334],"mg/kg":[331,335],"performed.":[338],"dose":[343,352],"proportionality":[344],"does":[347],"not":[348,362],"exist":[349],"range":[353],"studied.":[354],"Although":[355],"elimination":[357],"half":[358],"life":[359],"found":[361],"be":[364],"significant":[365,371],"different":[366],"between":[367,375],"FCAPE,":[370],"difference":[372,389],"observed":[374],"total":[377],"body":[378],"clearance":[379],"which":[384],"due":[386],"volume":[391],"distribution.":[393]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
