{"id":"https://openalex.org/W1770944666","doi":"https://doi.org/10.1002/gps.3867","title":"Double\u2010blind, randomized study of extended release quetiapine fumarate (quetiapine XR) monotherapy in older patients with generalized anxiety disorder","display_name":"Double\u2010blind, randomized study of extended release quetiapine fumarate (quetiapine XR) monotherapy in older patients with generalized anxiety disorder","publication_year":2012,"publication_date":"2012-10-16","ids":{"openalex":"https://openalex.org/W1770944666","doi":"https://doi.org/10.1002/gps.3867","mag":"1770944666","pmid":"https://pubmed.ncbi.nlm.nih.gov/23070803"},"language":"en","primary_location":{"id":"doi:10.1002/gps.3867","doi":"https://doi.org/10.1002/gps.3867","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gps.3867","pdf_url":null,"source":{"id":"https://openalex.org/S77085303","display_name":"International Journal of Geriatric Psychiatry","issn_l":"0885-6230","issn":["0885-6230","1099-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Geriatric Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029373985","display_name":"Irina Mezhebovsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Irina Mezhebovsky","raw_affiliation_strings":["Boston Clinical Trials, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Clinical Trials, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029480160","display_name":"Kairi M\u00e4gi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802241215","display_name":"Tartu University Hospital","ror":"https://ror.org/01dm91j21","country_code":"EE","type":"healthcare","lineage":["https://openalex.org/I2802241215"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kairi M\u00e4gi","raw_affiliation_strings":["Psychiatric Clinic of Tartu University Hospital, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Clinic of Tartu University Hospital, Tartu, Estonia","institution_ids":["https://openalex.org/I2802241215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065015649","display_name":"Fahua She","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahua She","raw_affiliation_strings":["AstraZeneca Pharmaceuticals Wilmington DE USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals Wilmington DE USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071274095","display_name":"Catherine J Datto","orcid":"https://orcid.org/0000-0002-5804-3113","observed_orcids":["https://orcid.org/0000-0002-5804-3113"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Datto","raw_affiliation_strings":["AstraZeneca Pharmaceuticals Wilmington DE USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals Wilmington DE USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103127258","display_name":"Hans Eriksson","orcid":"https://orcid.org/0000-0002-1799-289X","observed_orcids":["https://orcid.org/0000-0002-1799-289X"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hans Eriksson","raw_affiliation_strings":["AstraZeneca Pharmaceuticals R&amp;D S\u00f6dert\u00e4lje  Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals R&amp;D S\u00f6dert\u00e4lje  Sweden","institution_ids":["https://openalex.org/I4210143795"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029373985"],"corresponding_institution_ids":[],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":7.2862,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.96185047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"6","first_page":"615","last_page":"625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6909999847412109},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":0.9890000224113464},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9300000071525574},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.906000018119812},{"id":"https://openalex.org/keywords/anxiety-symptom-reduction","display_name":"anxiety symptom reduction","score":0.5199999809265137},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.7929999828338623},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8180000185966492},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sleepiness","display_name":"sleepiness","score":0.9319999814033508},{"id":"https://openalex.org/keywords/comorbid-depression","display_name":"comorbid depression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/flexible-dosing","display_name":"flexible dosing","score":0.7039999961853027},{"id":"https://openalex.org/keywords/post-treatment-follow-up","display_name":"post-treatment follow-up","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.9160913825035095},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7128045558929443},{"id":"https://openalex.org/C2911140283","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine Fumarate","level":5,"score":0.6906414031982422},{"id":"https://openalex.org/C2777696351","wikidata":"https://www.wikidata.org/wiki/Q5644839","display_name":"Hamilton Anxiety Rating Scale","level":3,"score":0.5198312401771545},{"id":"https://openalex.org/C2776000289","wikidata":"https://www.wikidata.org/wiki/Q5133761","display_name":"Clinical Global Impression","level":4,"score":0.5146130323410034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5066009759902954},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.4767238199710846},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.4635580778121948},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46092909574508667},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.446774959564209},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4374852776527405},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4037700295448303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3900052011013031},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36202991008758545},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.18982595205307007},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.08086952567100525},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gps.3867","doi":"https://doi.org/10.1002/gps.3867","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gps.3867","pdf_url":null,"source":{"id":"https://openalex.org/S77085303","display_name":"International Journal of Geriatric Psychiatry","issn_l":"0885-6230","issn":["0885-6230","1099-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Geriatric Psychiatry","raw_type":"journal-article"},{"id":"pmid:23070803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23070803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of geriatric psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1917909847","https://openalex.org/W1944222706","https://openalex.org/W1964216818","https://openalex.org/W1965144024","https://openalex.org/W1966065460","https://openalex.org/W1967994438","https://openalex.org/W1968262411","https://openalex.org/W1993810555","https://openalex.org/W1995006301","https://openalex.org/W1996297708","https://openalex.org/W1998210226","https://openalex.org/W2013635412","https://openalex.org/W2022191212","https://openalex.org/W2033335882","https://openalex.org/W2036260146","https://openalex.org/W2036556626","https://openalex.org/W2039250125","https://openalex.org/W2047428847","https://openalex.org/W2057286542","https://openalex.org/W2058966265","https://openalex.org/W2067903360","https://openalex.org/W2072344162","https://openalex.org/W2073887722","https://openalex.org/W2090551102","https://openalex.org/W2098344591","https://openalex.org/W2104022065","https://openalex.org/W2109152854","https://openalex.org/W2119700347","https://openalex.org/W2128295544","https://openalex.org/W2131823335","https://openalex.org/W2139280604","https://openalex.org/W2155441883","https://openalex.org/W2160070901","https://openalex.org/W2178264880","https://openalex.org/W2196573549","https://openalex.org/W3005563669","https://openalex.org/W3171418018","https://openalex.org/W7074234824"],"related_works":["https://openalex.org/W1965144024","https://openalex.org/W2036260146","https://openalex.org/W2139280604","https://openalex.org/W1998982846","https://openalex.org/W1993810555","https://openalex.org/W1545645532","https://openalex.org/W2534000589","https://openalex.org/W1531631989","https://openalex.org/W2104991438","https://openalex.org/W7206904117"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"objective":[2],"of":[3,37,67,76,87,92,96,107,210,231,267,292],"the":[4,261,289],"study":[5,35],"was":[6,167],"to":[7,128],"evaluate":[8],"once-daily":[9],"extended":[10],"release":[11],"quetiapine":[12,39,129,142,163,178],"fumarate":[13],"(quetiapine":[14],"XR)":[15],"monotherapy":[16,257],"in":[17,120,240,260,264,269],"older":[18,270],"patients":[19,227,271],"with":[20,64,78,162,228,272,274,288],"generalized":[21],"anxiety":[22,268],"disorder":[23],"(GAD).":[24],"METHODS:":[25],"An":[26],"11-week":[27],"(9-week":[28],"treatment;":[29],"2-week":[30],"posttreatment),":[31],"randomized,":[32],"double-blind,":[33],"placebo-controlled":[34],"(D1448C00015)":[36],"flexibly-dosed":[38],"XR":[40,130,143,164,179,254],"(50-300":[41,255],"mg/day)":[42,256],"or":[43,134],"placebo":[44,135,150,166,184],"conducted":[45],"at":[46,169],"47":[47],"sites":[48],"(Estonia,":[49],"Poland,":[50],"Russia,":[51],"Ukraine,":[52],"and":[53,58,83,98,188,193,208,213,222,250],"USA)":[54],"between":[55],"September":[56],"2006":[57],"April":[59],"2008.":[60],"Patients":[61,125],"(\u226566":[62],"years)":[63],"DSM-IV":[65],"diagnosis":[66],"GAD,":[68,273],"Hamilton":[69],"Anxiety":[70],"Rating":[71,102],"Scale":[72,103],"(HAM-A)":[73],"total":[74,105,122,147,220],"score":[75,95,106,148,230],"\u226520":[77],"item":[79],"1":[80,171],"(anxious":[81],"mood)":[82],"2":[84],"(tension)":[85],"scores":[86,221],"\u22652,":[88],"Clinical":[89,223],"Global":[90,224],"Impressions-Severity":[91],"Illness":[93],"(CGI-S)":[94],"\u22654,":[97],"Montgomery":[99],"\u00c5sberg":[100],"Depression":[101],"(MADRS)":[104],"\u226416":[108],"were":[109,126,285],"eligible":[110],"for":[111,185],"inclusion.":[112],"Primary":[113],"endpoint:":[114],"week":[115,140,170,176,281],"9":[116],"change":[117],"from":[118],"randomization":[119],"HAM-A":[121,146,186,191],"score.":[123],"RESULTS:":[124],"randomized":[127],"(n":[131,136],"=":[132,137],"223)":[133],"227).":[138],"At":[139,175],"9,":[141,177],"significantly":[144],"reduced":[145],"versus":[149,155,165],"(least":[151],"squares":[152],"mean":[153],"-14.97":[154],"-7.21;":[156],"p":[157,234],"<":[158,173,235],"0.001);":[159],"symptom":[160,275],"improvement":[161,276],"significant":[168,181],"(p":[172],"0.001).":[174,236],"demonstrated":[180],"benefits":[182],"over":[183],"response":[187],"remission":[189],"rates,":[190],"psychic":[192],"somatic":[194],"cluster,":[195],"MADRS":[196],"total,":[197],"CGI-S,":[198],"Pittsburgh":[199],"Sleep":[200],"Quality":[201,209],"Index":[202],"global,":[203],"pain":[204],"visual":[205],"analog":[206],"scale,":[207],"Life,":[211],"Enjoyment":[212],"Satisfaction":[214],"Questionnaire":[215],"short":[216,262],"form":[217],"%":[218],"maximum":[219],"Impressions-Improvement":[225],"(%":[226],"a":[229],"1/2)":[232],"(all":[233],"Adverse":[237],"events":[238],"(>5%":[239],"either":[241],"treatment":[242],"group)":[243],"included":[244],"somnolence,":[245],"dry":[246],"mouth,":[247],"dizziness,":[248],"headache,":[249],"nausea.":[251],"CONCLUSIONS:":[252],"Quetiapine":[253],"is":[258],"effective":[259],"term":[263],"improving":[265],"symptoms":[266],"seen":[277],"as":[278,280],"early":[279],"1.":[282],"Tolerability":[283],"findings":[284],"generally":[286],"consistent":[287],"known":[290],"profile":[291],"quetiapine.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}