{"id":"https://openalex.org/W177092972","doi":null,"title":"The cytoskeleton of the cultured human trabecular cell. Characterization and drug responses.","display_name":"The cytoskeleton of the cultured human trabecular cell. Characterization and drug responses.","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W177092972","mag":"177092972","pmid":"https://pubmed.ncbi.nlm.nih.gov/2892811"},"language":"en","primary_location":{"id":"pmid:2892811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2892811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078139841","display_name":"Mark I. Ryder","orcid":"https://orcid.org/0000-0002-8540-4017","observed_orcids":["https://orcid.org/0000-0002-8540-4017"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M I Ryder","raw_affiliation_strings":["Department of Ophthalmology, University of California, San Diego, La Jolla 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of California, San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043994887","display_name":"Robert Neal Weinreb","orcid":"https://orcid.org/0000-0001-9553-3202","observed_orcids":["https://orcid.org/0000-0001-9553-3202","https://orcid.org/0000-0003-4217-4853"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Weinreb","raw_affiliation_strings":["Department of Ophthalmology, University of California, San Diego, La Jolla 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of California, San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062409605","display_name":"Jorge A. Alvarado","orcid":"https://orcid.org/0000-0002-1677-361X","observed_orcids":["https://orcid.org/0000-0002-1677-361X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Alvarado","raw_affiliation_strings":["Department of Ophthalmology, University of California, San Diego, La Jolla 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of California, San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110033520","display_name":"Jon R. Polansky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Polansky","raw_affiliation_strings":["Department of Ophthalmology, University of California, San Diego, La Jolla 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of California, San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.6252,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.65107084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"2","first_page":"251","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.08299999684095383,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trabecular-meshwork-cells","display_name":"trabecular meshwork cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.9419999718666077},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.996999979019165},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":1.0},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9800000190734863},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.996999979019165},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.8966017961502075},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.707645058631897},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6747130751609802},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6653525829315186},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6261339783668518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6107754707336426},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6053705811500549},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.6047310829162598},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.6018949747085571},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.5123363733291626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5099972486495972},{"id":"https://openalex.org/C2776041460","wikidata":"https://www.wikidata.org/wiki/Q5201339","display_name":"Cytochalasin D","level":4,"score":0.4842798113822937},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.482698917388916},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.4784238934516907},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1034289300441742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08769106864929199},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06741860508918762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05237242579460144},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2892811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2892811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:177092972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2892811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W206972054","https://openalex.org/W2471276139","https://openalex.org/W2078113817","https://openalex.org/W1536573184","https://openalex.org/W2004523935","https://openalex.org/W2411988441","https://openalex.org/W2089237744","https://openalex.org/W69062978","https://openalex.org/W7099612237","https://openalex.org/W2041558872"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,5,55,77,125,166],"organization":[3,164],"of":[4,10,30,68,110,154],"three":[6,145],"major":[7],"cytoskeletal":[8,80,146,163],"elements":[9],"cultured":[11,167],"human":[12,117,168],"trabecular":[13,58,118,169],"meshwork":[14],"cells":[15],"(actin":[16],"filaments,":[17],"microtubules":[18,73],"and":[19,26,34,48,66,72,88,99,162],"intermediate":[20],"filaments),":[21],"we":[22],"employed":[23],"fluorescence":[24],"microscopy":[25,29],"stereo-transmission":[27],"electron":[28],"extracted,":[31],"S-1":[32],"labeled":[33],"critical-point":[35],"dried":[36],"cells.":[37],"Morphologic":[38],"changes":[39,115,142],"resulting":[40],"from":[41],"treatment":[42,123],"with":[43,54,124,140],"cytochalasin":[44,128],"B,":[45],"colchicine,":[46],"taxol":[47],"nocodozole":[49,87,98],"were":[50,74,83],"also":[51],"characterized.":[52],"Compared":[53],"cynomolgus":[56],"monkey":[57],"cell,":[59],"morphologic":[60],"differences":[61],"in":[62,116,131,136,143,157,165],"overall":[63,159],"cell":[64,119,137,160],"shape":[65,138,161],"orientation":[67],"both":[69,132],"actin":[70,155],"filaments":[71,156],"noted.":[75],"However,":[76],"responses":[78],"to":[79],"active":[81],"drugs":[82,112],"quite":[84],"similar.":[85],"Taxol,":[86],"colchicine":[89,100],"had":[90,101],"a":[91,102,133,151],"marked":[92,103,114,134],"effect":[93,104],"on":[94,105],"microtubule":[95],"organization,":[96],"while":[97],"vimentin":[106],"filament":[107],"organization.":[108],"None":[109],"these":[111],"produced":[113],"shape.":[120],"In":[121],"contrast,":[122],"anti-actin":[126],"drug":[127],"B":[129],"resulted":[130],"change":[135],"associated":[139],"organizational":[141],"all":[144],"elements.":[147],"These":[148],"studies":[149],"suggest":[150],"central":[152],"role":[153],"determining":[158],"cell.":[170]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
