{"id":"https://openalex.org/W177004391","doi":null,"title":"Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma.","display_name":"Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma.","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W177004391","mag":"177004391","pmid":"https://pubmed.ncbi.nlm.nih.gov/25774481"},"language":"en","primary_location":{"id":"pmid:25774481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25774481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040552120","display_name":"Nader Kim El\u2010Mallawany","orcid":"https://orcid.org/0000-0001-6115-1046","observed_orcids":["https://orcid.org/0000-0001-6115-1046"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nader Kim El-Mallawany","raw_affiliation_strings":["New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001697191","display_name":"Mitchell Stuart Cairo","orcid":"https://orcid.org/0000-0002-2075-434X","observed_orcids":["https://orcid.org/0000-0002-2075-434X"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell S Cairo","raw_affiliation_strings":["New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":3.1778,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91726828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"113","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-non-hodgkin-lymphoma","display_name":"B-cell non-Hodgkin lymphoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":1.0},{"id":"https://openalex.org/keywords/pediatric-lymphoma","display_name":"pediatric lymphoma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adolescent-lymphoma","display_name":"adolescent lymphoma","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.9160000085830688},{"id":"https://openalex.org/keywords/chemotherapy-regimens","display_name":"chemotherapy regimens","score":0.6940000057220459},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.925000011920929},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9233219623565674},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7312664985656738},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.7225551605224609},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5746892094612122},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5513097643852234},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5458609461784363},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5452289581298828},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4662054777145386},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.42989373207092285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41333910822868347},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4100349247455597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3848947584629059},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2719890773296356}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25774481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25774481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},{"id":"mag:177004391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25774481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W15360658","https://openalex.org/W1724331497","https://openalex.org/W1964898740","https://openalex.org/W1970828429","https://openalex.org/W1974184061","https://openalex.org/W1984151990","https://openalex.org/W1985103890","https://openalex.org/W1988779324","https://openalex.org/W1991644988","https://openalex.org/W1991890073","https://openalex.org/W1995314727","https://openalex.org/W1999105034","https://openalex.org/W2000142787","https://openalex.org/W2000871066","https://openalex.org/W2001196047","https://openalex.org/W2003089766","https://openalex.org/W2003546214","https://openalex.org/W2008143837","https://openalex.org/W2011539491","https://openalex.org/W2015098191","https://openalex.org/W2025214835","https://openalex.org/W2027053879","https://openalex.org/W2045399297","https://openalex.org/W2045940197","https://openalex.org/W2048773859","https://openalex.org/W2056545314","https://openalex.org/W2064002706","https://openalex.org/W2066564017","https://openalex.org/W2071549499","https://openalex.org/W2077362224","https://openalex.org/W2078069330","https://openalex.org/W2083435401","https://openalex.org/W2091057822","https://openalex.org/W2105400883","https://openalex.org/W2109687784","https://openalex.org/W2111500154","https://openalex.org/W2119055881","https://openalex.org/W2120319857","https://openalex.org/W2121227413","https://openalex.org/W2130011407","https://openalex.org/W2133131759","https://openalex.org/W2134861285","https://openalex.org/W2135802989","https://openalex.org/W2136725907","https://openalex.org/W2139539910","https://openalex.org/W2141819662","https://openalex.org/W2143901303","https://openalex.org/W2145453495","https://openalex.org/W2147047596","https://openalex.org/W2147086069","https://openalex.org/W2154066874","https://openalex.org/W2157069955","https://openalex.org/W2164337721","https://openalex.org/W2171771895","https://openalex.org/W2394732045","https://openalex.org/W2417043811","https://openalex.org/W2418093107","https://openalex.org/W2536134588"],"related_works":["https://openalex.org/W2135045926","https://openalex.org/W2910201624","https://openalex.org/W3010287168","https://openalex.org/W2938396047","https://openalex.org/W3047524085","https://openalex.org/W2565112719","https://openalex.org/W2094927988","https://openalex.org/W2991092288","https://openalex.org/W1860370181","https://openalex.org/W4408014666"],"abstract_inverted_index":{"Burkitt":[0],"lymphoma":[1,6],"and":[2,18,28,38,81,111,124],"diffuse":[3],"large":[4],"B-cell":[5,12],"represent":[7],"the":[8,31,42,62,86,89],"majority":[9],"of":[10,56,61,103],"mature":[11],"non-Hodgkin":[13],"lymphomas":[14],"in":[15,46,85,108,145],"children,":[16,109],"adolescents,":[17,110],"young":[19,112],"adults.":[20],"Although":[21],"they":[22],"are":[23,39,138,142],"characterized":[24],"by":[25],"specific":[26,132],"clinical":[27,146],"biological":[29],"nuances,":[30],"2":[32],"diseases":[33],"share":[34],"significant":[35],"clinicopathologic":[36],"overlap":[37],"treated":[40],"with":[41,94,114],"same":[43],"chemotherapy":[44,49,69],"regimens":[45],"pediatrics.":[47],"Modern-day":[48],"protocols":[50],"achieve":[51],"overall":[52],"event-free":[53],"survival":[54,91],"rates":[55],"nearly":[57],"90%.":[58],"The":[59,101],"addition":[60],"anti-CD20":[63],"monoclonal":[64],"antibody":[65],"rituximab":[66],"to":[67],"backbone":[68],"holds":[70],"great":[71],"promise":[72],"for":[73,92],"improving":[74],"long-term":[75,82,90],"curative":[76],"outcomes":[77],"while":[78],"diminishing":[79],"acute":[80],"toxicities.":[83],"However,":[84],"contemporary":[87],"era,":[88],"patients":[93],"relapsed":[95],"or":[96],"refractory":[97],"disease":[98,116],"is":[99,117],"meager.":[100],"role":[102],"hematopoietic":[104],"stem":[105],"cell":[106],"transplantation":[107],"adults":[113],"relapsed/refractory":[115],"currently":[118],"being":[119,143],"defined.":[120],"Meanwhile,":[121],"novel":[122],"humoral":[123],"cellular":[125],"immunotherapies,":[126],"as":[127,129],"well":[128],"agents":[130],"targeting":[131],"molecular":[133],"pathways":[134],"that":[135,141],"drive":[136],"lymphomagenesis,":[137],"exciting":[139],"developments":[140],"evaluated":[144],"trials.":[147]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}