{"id":"https://openalex.org/W176960585","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","title":"Pregnancy status and choline intake alter DNA integrity, epigenetic marks and gene expression","display_name":"Pregnancy status and choline intake alter DNA integrity, epigenetic marks and gene expression","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W176960585","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","mag":"176960585"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.116.1","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063512499","display_name":"Xinyin Jiang","orcid":"https://orcid.org/0000-0001-6090-371X","observed_orcids":["https://orcid.org/0000-0001-6090-371X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyin Jiang","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064901980","display_name":"Jian Yan","orcid":"https://orcid.org/0000-0001-8597-9841","observed_orcids":["https://orcid.org/0000-0001-8597-9841"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Yan","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013199881","display_name":"Allyson A. West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allyson West","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086808734","display_name":"Cydne A. Perry","orcid":"https://orcid.org/0000-0001-8874-1978","observed_orcids":["https://orcid.org/0000-0001-8874-1978"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cydne Perry","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040098215","display_name":"Olga Malysheva","orcid":"https://orcid.org/0000-0002-8626-5071","observed_orcids":["https://orcid.org/0000-0002-8626-5071"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Malysheva","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071502133","display_name":"Haim Bar","orcid":"https://orcid.org/0000-0002-5496-9699","observed_orcids":["https://orcid.org/0000-0002-5496-9699"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haim Bar","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Statistical Science Cornell University Ithaca NY","2--> Statistical Science Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Statistical Science Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"2--> Statistical Science Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084409300","display_name":"Martin T. Wells","orcid":"https://orcid.org/0000-0002-9750-9529","observed_orcids":["https://orcid.org/0000-0002-9750-9529"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Wells","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Statistical Science Cornell University Ithaca NY","2--> Statistical Science Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Statistical Science Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"2--> Statistical Science Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016963833","display_name":"Srisatish Devapatla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srisatish Devapatla","raw_affiliation_strings":["<!--<label><sup>3</sup></label>--> Department of Pediatrics Cayuga Medical Center Ithaca NY","3--> Department of Pediatrics Cayuga Medical Center Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>3</sup></label>--> Department of Pediatrics Cayuga Medical Center Ithaca NY","institution_ids":[]},{"raw_affiliation_string":"3--> Department of Pediatrics Cayuga Medical Center Ithaca NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045530377","display_name":"Eva K. Pressman","orcid":"https://orcid.org/0000-0002-2556-9290","observed_orcids":["https://orcid.org/0000-0002-2556-9290"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Pressman","raw_affiliation_strings":["<!--<label><sup>4</sup></label>--> Obstetrics and Gynecology University of Rochester Medical Center Rochester NY","4--> Obstetrics and Gynecology University of Rochester Medical Center Rochester NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>4</sup></label>--> Obstetrics and Gynecology University of Rochester Medical Center Rochester NY","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"4--> Obstetrics and Gynecology University of Rochester Medical Center Rochester NY","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077583806","display_name":"Marie A. Caudill","orcid":"https://orcid.org/0000-0002-7192-5743","observed_orcids":["https://orcid.org/0000-0002-7192-5743"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie Caudill","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","1--> Division of Nutritional Sciences Cornell University Ithaca NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"1--> Division of Nutritional Sciences Cornell University Ithaca NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.01194717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.12720000743865967,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8899999856948853},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.8119999766349792},{"id":"https://openalex.org/keywords/h3k4me2","display_name":"H3K4me2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.699999988079071},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.734000027179718},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8989999890327454},{"id":"https://openalex.org/keywords/third-trimester","display_name":"third trimester","score":0.6740000247955322},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7839717864990234},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6744706630706787},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6070859432220459},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5472795367240906},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.527484118938446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5167204737663269},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48680874705314636},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.45247331261634827},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45076027512550354},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.44518184661865234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38538461923599243},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.369131863117218},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2823028564453125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2562903165817261},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19375643134117126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.116.1","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.116.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320311162","display_name":"Egg Nutrition Center","ror":"https://ror.org/00289h314"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087739992","https://openalex.org/W1830099512","https://openalex.org/W2794616837","https://openalex.org/W3167404281","https://openalex.org/W2114835551","https://openalex.org/W3170175683","https://openalex.org/W2028342249","https://openalex.org/W2302998400","https://openalex.org/W2020915761","https://openalex.org/W3109769987"],"abstract_inverted_index":{"This":[0],"study":[1],"sought":[2],"to":[3,31,58,79,97],"systemically":[4],"elucidate":[5],"the":[6,74,90,98,128,168],"effects":[7,150],"of":[8,35,76,92,115,123,130,138],"pregnancy":[9,120],"and":[10,25,49,126,154,167],"maternal":[11],"choline":[12,33,100,145],"intake":[13,101],"on":[14,151],"genomic":[15,124],"markers.":[16],"Healthy":[17],"third":[18],"trimester":[19],"pregnant":[20,141],"(n=26,":[21],"wk":[22,47],"27":[23],"gestation)":[24],"non\u2010pregnant":[26,59],"(n=21)":[27],"women":[28,52,60,95,142],"were":[29,44],"randomized":[30],"controlled":[32],"intakes":[34,146],"480":[36],"or":[37],"930":[38],"mg/day":[39],"for":[40],"12\u2010wk.":[41],"Leukocyte":[42],"samples":[43],"acquired":[45],"at":[46],"0":[48],"12.":[50],"Pregnant":[51,94],"had":[53],"higher":[54,99],"DNA":[55],"damage":[56],"compared":[57],"(P":[61,104],"<":[62,105],"0.001),":[63],"suggesting":[64],"insufficient":[65],"defense":[66,87],"against":[67],"oxidative":[68],"stress.":[69],"Genome\u2010wide":[70],"transcript":[71],"profiling":[72],"revealed":[73],"up\u2010regulation":[75],"genes":[77,132],"related":[78],"immune":[80],"response,":[81],"consistent":[82],"with":[83,102],"an":[84],"activated":[85],"host":[86],"system":[88],"towards":[89],"end":[91],"pregnancy.":[93],"responded":[96],"increased":[103],"0.05)":[106],"histone":[107],"3":[108],"lysine":[109],"4":[110],"di\u2010methylation":[111],"(H3K4me2),":[112],"a":[113],"marker":[114],"transcription":[116],"activation.":[117],"In":[118],"sum,":[119],"altered":[121],"markers":[122],"stability":[125],"modulated":[127],"expression":[129],"immune\u2010related":[131],"in":[133,162],"leukocytes.":[134],"The":[135],"epigenetic":[136],"modification":[137],"histones":[139],"among":[140],"consuming":[143],"varied":[144],"may":[147],"have":[148],"downstream":[149],"chromatin":[152],"restructuring":[153],"gene":[155],"transcription.":[156],"Grant":[157],"Funding":[158],"Source":[159],":":[160],"Funded":[161],"part":[163],"by":[164],"USDA,":[165],"ENC":[166],"Beef":[169],"Checkoff":[170],"through":[171],"NCBA":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}