{"id":"https://openalex.org/W176947166","doi":null,"title":"L' interleukine-33, un nouvel acteur de la r\u00e9ponse anti-tumorale dans un mod\u00e8le murin de cancer du c\u00f4lon","display_name":"L' interleukine-33, un nouvel acteur de la r\u00e9ponse anti-tumorale dans un mod\u00e8le murin de cancer du c\u00f4lon","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W176947166","mag":"176947166"},"language":"fr","primary_location":{"id":"pmh:oai:thesesups.ups-tlse.fr:2420","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","pdf_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013794068","display_name":"Emilie Mirey","orcid":"https://orcid.org/0009-0006-7631-6214","observed_orcids":["https://orcid.org/0009-0006-7631-6214"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emilie Mirey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013794068"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.996999979019165},{"id":"https://openalex.org/keywords/st2-receptor","display_name":"ST2 receptor","score":0.843999981880188},{"id":"https://openalex.org/keywords/il-1-cytokine-family","display_name":"IL-1 family cytokines","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5360000133514404},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7760000228881836},{"id":"https://openalex.org/keywords/il-33-st2-signaling","display_name":"IL-33/ST2 signaling","score":0.6179999709129333},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5130000114440918},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.49900001287460327},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.38499999046325684},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.8229254484176636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4171161353588104}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:thesesups.ups-tlse.fr:2420","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","pdf_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},{"id":"mag:176947166","doi":null,"is_oa":false,"landing_page_url":"http://thesesups.ups-tlse.fr/2420/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:thesesups.ups-tlse.fr:2420","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","pdf_url":"http://thesesups.ups-tlse.fr/2420/1/2014TOU30116.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W176947166.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7139740763","https://openalex.org/W7148585612","https://openalex.org/W7214252174","https://openalex.org/W7149497305","https://openalex.org/W4285384420","https://openalex.org/W136174863","https://openalex.org/W2343691465","https://openalex.org/W6903162712","https://openalex.org/W4409255937","https://openalex.org/W2900835420"],"abstract_inverted_index":{"L'interleukine-33":[0],"(IL-33)":[1],"est":[2,12,53,235,320,491],"une":[3,92,188,314,459,520],"cytokine":[4,460],"nucl\u00e9aire":[5],"de":[6,15,32,49,56,71,84,101,124,131,136,147,165,170,206,231,237,245,254,274,293,302,318,355,453,457,469,478,499,530,540],"la":[7,45,132,137,148,171,195,209,303,344,368,372,384,405,412,531],"famille":[8,46,133],"des":[9,47,126,129,326,330,340,374,399,448,511],"interleukines-1.":[10],"L'IL-33":[11],"exprim\u00e9e":[13,236],"par":[14,240,271,427,484],"nombreux":[16],"\u00e9pith\u00e9liums":[17],"en":[18,99,267,386,436],"contact":[19],"avec":[20,39],"l'environnement":[21],"et":[22,128,161,211,295,329,429,446,450,508,537],"peut":[23,37,260],"\u00eatre":[24,261],"lib\u00e9r\u00e9e":[25,483],"sous":[26],"sa":[27],"forme":[28,35],"pleine":[29],"taille":[30],"lors":[31,135,146,273],"n\u00e9crose.":[33],"Cette":[34],"active":[36],"interagir":[38],"le":[40,96,162,203,290,397,444,538],"r\u00e9cepteur":[41],"ST2":[42,52],"appartenant":[43],"\u00e0":[44,152,187,215,313,351,376,509,515],"r\u00e9cepteurs":[48],"l'IL-1":[50],"(IL-1R4).":[51],"pr\u00e9sent":[54],"sur":[55],"nombreuses":[57],"cellules":[58,265,327,331,341,486],"du":[59,198,333,347,357,401,480],"syst\u00e8me":[60,97],"immunitaire":[61,98],"aussi":[62],"bien":[63],"impliqu\u00e9es":[64],"dans":[65,113,263,308,323,338,361,388,411,422,465,475,534],"l'immunit\u00e9":[66,535],"inn\u00e9e":[67],"(cellules":[68],"lympho\u00efdes":[69],"inn\u00e9es":[70],"type":[72,470],"2":[73],"ou":[74,104,119,488],"ILC2,":[75,495],"mastocytes,":[76],"NK,...)":[77],"qu'adaptative":[78],"(lymphocytes":[79],"Th2,":[80],"T":[81],"CD8,...).":[82],"L'ensemble":[83],"ces":[85,389],"propri\u00e9t\u00e9s":[86],"sugg\u00e8rent":[87,526],"que":[88,224,307,337,367,433,443,474],"l'IL-33":[89,139,166,207,234,248,294,319,410,428,454,482],"fonctionne":[90],"comme":[91,270],"alarmine":[93],"charg\u00e9e":[94],"d'alerter":[95],"cas":[100],"dommage":[102],"cellulaire":[103],"tissulaire.":[105,542],"L'axe":[106],"IL-33/ST2":[107],"semble":[108],"jouer":[109,142],"un":[110,143,180,309,378,462,527],"r\u00f4le":[111,144,163,298,463,528],"pr\u00e9pond\u00e9rant":[112],"les":[114,241,264,324,418,434,438,466,485,494],"pathologies":[115],"inflammatoires":[116],"chroniques,":[117],"allergiques":[118],"encore":[120,158],"infectieuses.":[121],"Compte":[122],"tenu":[123],"l'implication":[125],"alarmines":[127],"membres":[130],"IL-1":[134],"tumorigen\u00e8se,":[138],"pourrait":[140],"\u00e9galement":[141],"important":[145],"progression":[149],"tumorale.":[150],"Cependant,":[151],"ce":[153,175,225,280,476,503],"jour,":[154],"aucune":[155],"\u00e9tude":[156],"n'a":[157],"caract\u00e9ris\u00e9":[159,202,417],"l'expression":[160,317],"potentiel":[164,299],"endog\u00e8ne":[167],"au":[168,252,300,506],"cours":[169,301],"tumorigen\u00e8se.":[172,304],"Pour":[173],"r\u00e9aliser":[174],"projet,":[176],"nous":[177,200,212,349,408,430],"avons":[178,201,222,277,416,431],"d\u00e9velopp\u00e9":[179],"mod\u00e8le":[181,281,354,477],"murin":[182,282],"invalid\u00e9":[183],"pour":[184,288,365,404],"l'Il-33":[185],"gr\u00e2ce":[186],"strat\u00e9gie":[189],"\"":[190,283,287,391,395],"Gene":[191,285,393],"Trap":[192,286,394],"\".":[193],"Dans":[194,343],"premi\u00e8re":[196,406],"partie":[197,346],"travail,":[199,348],"profil":[204,226,291],"d'expression":[205,227,292],"chez":[208,219],"souris":[210,375,390],"l'avons":[213],"compar\u00e9":[214],"celui":[216,230],"d\u00e9crit":[217],"pr\u00e9c\u00e9demment":[218],"l'Homme.":[220],"Nous":[221,276,305,415,441,472],"montr\u00e9":[223],"recouvre":[228],"partiellement":[229],"l'Homme":[232],"puisque":[233],"mani\u00e8re":[238,246],"constitutive":[239],"\u00e9pith\u00e9liums.":[242],"En":[243],"revanche,":[244],"surprenante,":[247],"n'est":[249],"pas":[250],"retrouv\u00e9e":[251],"niveau":[253],"l'endoth\u00e9lium,":[255],"m\u00eame":[256],"si":[257],"son":[258,297],"expression":[259],"induite":[262,322],"endoth\u00e9liales":[266,328],"contexte":[268,310],"inflammatoire":[269],"exemple":[272],"colite.":[275],"ensuite":[278],"utilis\u00e9":[279],"Il-33":[284,392],"d\u00e9crire":[289],"\u00e9tudier":[296],"montrons":[306,350,442],"tumoral":[311],"associ\u00e9":[312],"inflammation":[315],"chronique,":[316],"fortement":[321],"noyaux":[325],"m\u00e9senchymateuses":[332],"microenvironnement":[334],"tumoral,":[335],"ainsi":[336],"ceux":[339],"canc\u00e9reuses.":[342],"deuxi\u00e8me":[345],"l'aide":[352],"d'un":[353],"carcinome":[356],"c\u00f4lon":[358],"induit":[359],"chimiquement":[360],"notre":[362],"lign\u00e9e":[363],"invalid\u00e9e":[364],"l'Il-33,":[366],"perte":[369],"d'IL-33":[370],"augmente":[371],"susceptibilit\u00e9":[373],"d\u00e9velopper":[377],"cancer":[379,479],"colorectal.":[380],"De":[381],"fa\u00e7on":[382],"int\u00e9ressante,":[383],"restauration":[385],"IL-33":[387],"inhibe":[396],"d\u00e9veloppement":[398],"tumeurs":[400],"colon.":[402],"Ainsi,":[403,523],"fois,":[407],"impliquons":[409],"r\u00e9ponse":[413,424,521],"anti-tumorale.":[414,522],"acteurs":[419],"cellulaires":[420],"impliqu\u00e9s":[421],"cette":[423],"anti-tumorale":[425,536],"initi\u00e9e":[426],"d\u00e9couvert":[432],"\u00e9osinophiles":[435,512],"sont":[437,455],"principaux":[439],"responsables.":[440],"recrutement":[445,507],"l'activation":[447,510],"\u00e9osinophiles,":[449],"l'effet":[451],"anti-tumoral":[452],"d\u00e9pendants":[456],"l'IL-5,":[458],"jouant":[461],"cl\u00e9":[464,529],"r\u00e9ponses":[467],"immunitaires":[468],"2.":[471],"proposons":[473],"c\u00f4lon,":[481],"endoth\u00e9liales,":[487],"l'\u00e9pith\u00e9lium":[489],"transform\u00e9":[490],"capable":[492],"d'activer":[493],"qui":[496,504,513],"vont":[497,514],"lib\u00e9rer":[498],"grandes":[500],"quantit\u00e9s":[501],"d'IL-5,":[502],"conduit":[505],"leur":[516],"tour":[517],"pouvoir":[518],"exercer":[519],"nos":[524],"r\u00e9sultats":[525],"voie":[532],"IL-33/ILC2":[533],"maintien":[539],"l'hom\u00e9ostasie":[541]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}