{"id":"https://openalex.org/W176932084","doi":"https://doi.org/10.1007/bf01735261","title":"Tryptophan-Metabolismus bei Lebererkrankungen: Eine pharmakokinetische und enzymatische Untersuchung","display_name":"Tryptophan-Metabolismus bei Lebererkrankungen: Eine pharmakokinetische und enzymatische Untersuchung","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W176932084","doi":"https://doi.org/10.1007/bf01735261","mag":"176932084","pmid":"https://pubmed.ncbi.nlm.nih.gov/3747417"},"language":"de","primary_location":{"id":"doi:10.1007/bf01735261","doi":"https://doi.org/10.1007/bf01735261","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01735261","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016637736","display_name":"Martin P. Rossle","orcid":"https://orcid.org/0000-0002-1358-9163","observed_orcids":["https://orcid.org/0000-0002-1358-9163"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"M. R\u00f6ssle","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik, Freiburg","National Institute of Health, Building 10, Room 4D52, 20892, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik, Freiburg","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"National Institute of Health, Building 10, Room 4D52, 20892, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111032333","display_name":"R. Herz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Herz","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik, Freiburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik, Freiburg","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034349378","display_name":"B. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Klein","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik, Freiburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik, Freiburg","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071180693","display_name":"W. Gerok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Gerok","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik, Freiburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik, Freiburg","institution_ids":["https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.0200058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"64","issue":"13","first_page":"590","last_page":"594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.2337999939918518,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tryptophan-2-3-dioxygenase","display_name":"tryptophan 2,3-dioxygenase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7940000295639038},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.6150000095367432},{"id":"https://openalex.org/keywords/parenteral-nutrition","display_name":"parenteral nutrition","score":0.7689999938011169},{"id":"https://openalex.org/keywords/oral-nutrition","display_name":"oral nutrition","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7591731548309326},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.7384053468704224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6579297780990601},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.6179879903793335},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5914386510848999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5868000984191895},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5202566385269165},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.4743434488773346},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4682905077934265},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.44416919350624084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3797440230846405},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.32185599207878113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.217879980802536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1553116738796234},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014366","descriptor_name":"Tryptophan Oxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01735261","doi":"https://doi.org/10.1007/bf01735261","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01735261","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"journal-article"},{"id":"pmid:3747417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3747417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1487436709","https://openalex.org/W1519054363","https://openalex.org/W1571821264","https://openalex.org/W1737765280","https://openalex.org/W1798211609","https://openalex.org/W1848737662","https://openalex.org/W1921843724","https://openalex.org/W1985497749","https://openalex.org/W1994420004","https://openalex.org/W1997530163","https://openalex.org/W2001276295","https://openalex.org/W2019349340","https://openalex.org/W2038829093","https://openalex.org/W2050790183","https://openalex.org/W2051761535","https://openalex.org/W2068857017","https://openalex.org/W2074342488","https://openalex.org/W2074842014","https://openalex.org/W2082325583","https://openalex.org/W2085500802","https://openalex.org/W2089647714","https://openalex.org/W2093336310","https://openalex.org/W2111092087","https://openalex.org/W2144713807","https://openalex.org/W2166997341","https://openalex.org/W2169953089","https://openalex.org/W2234939054","https://openalex.org/W2326210376","https://openalex.org/W2397378004","https://openalex.org/W2415177606"],"related_works":["https://openalex.org/W2022195485","https://openalex.org/W2065816209","https://openalex.org/W108587789","https://openalex.org/W2400427712","https://openalex.org/W7098597881","https://openalex.org/W2001200940","https://openalex.org/W2409547543","https://openalex.org/W1491783886","https://openalex.org/W2011678179","https://openalex.org/W2409616203"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}