{"id":"https://openalex.org/W1768092345","doi":"https://doi.org/10.1042/bj20111575","title":"The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1)","display_name":"The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1)","publication_year":2012,"publication_date":"2012-05-04","ids":{"openalex":"https://openalex.org/W1768092345","doi":"https://doi.org/10.1042/bj20111575","mag":"1768092345","pmid":"https://pubmed.ncbi.nlm.nih.gov/22553920"},"language":"en","primary_location":{"id":"doi:10.1042/bj20111575","doi":"https://doi.org/10.1042/bj20111575","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111575","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101852581","display_name":"Qiong Lin","orcid":"https://orcid.org/0000-0002-4393-2495","observed_orcids":["https://orcid.org/0000-0002-4393-2495"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Qiong Lin","raw_affiliation_strings":["School of Medical Sciences and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China","Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China","institution_ids":["https://openalex.org/I115592961"]},{"raw_affiliation_string":"Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Laboratory of Molecular Biology of Medicine, Beijing Institute of Biotechnology, Beijing 100850, China","Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology of Medicine, Beijing Institute of Biotechnology, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078789463","display_name":"Chandra Childress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra Childress","raw_affiliation_strings":["Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058638868","display_name":"Wannian Yang","orcid":"https://orcid.org/0000-0002-1246-7260","observed_orcids":["https://orcid.org/0000-0002-1246-7260"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wannian Yang","raw_affiliation_strings":["Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weis Center for Research, Geisinger Clinic, 100 N. Academy Avenue, Danville, PA 17822, U.S.A","institution_ids":["https://openalex.org/I1293487830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101852581"],"corresponding_institution_ids":["https://openalex.org/I115592961","https://openalex.org/I1293487830"],"apc_list":null,"apc_paid":null,"fwci":1.2035,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.75666508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"445","issue":"2","first_page":"255","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ack1","display_name":"ACK1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tnk2","display_name":"TNK2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/kinase-activation-mechanism","display_name":"kinase activation mechanism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/autoinhibition","display_name":"autoinhibition","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/constitutive-activation","display_name":"constitutive activation","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6620677709579468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.611363410949707},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.6045845150947571},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5636683702468872},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.511769711971283},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4374327063560486},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.37266838550567627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32334983348846436},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3160591125488281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27499300241470337},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08140474557876587},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1042/bj20111575","doi":"https://doi.org/10.1042/bj20111575","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111575","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:22553920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22553920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1560781944","https://openalex.org/W1975189002","https://openalex.org/W1981218708","https://openalex.org/W1982178099","https://openalex.org/W1986276126","https://openalex.org/W2008631520","https://openalex.org/W2026469331","https://openalex.org/W2031117855","https://openalex.org/W2039377638","https://openalex.org/W2046151919","https://openalex.org/W2047425894","https://openalex.org/W2055013229","https://openalex.org/W2056922487","https://openalex.org/W2058741346","https://openalex.org/W2059248894","https://openalex.org/W2061152791","https://openalex.org/W2062709744","https://openalex.org/W2063167641","https://openalex.org/W2064406595","https://openalex.org/W2081511916","https://openalex.org/W2083140246","https://openalex.org/W2086140525","https://openalex.org/W2091322376","https://openalex.org/W2093390493","https://openalex.org/W2094009861","https://openalex.org/W2097312459","https://openalex.org/W2102197740","https://openalex.org/W2132448632","https://openalex.org/W2133244083","https://openalex.org/W2150909784","https://openalex.org/W2155152706","https://openalex.org/W2155824282"],"related_works":["https://openalex.org/W2102197740","https://openalex.org/W2106499057","https://openalex.org/W2091322376","https://openalex.org/W1986276126","https://openalex.org/W2063167641","https://openalex.org/W2092608482","https://openalex.org/W2132448632","https://openalex.org/W1994545036","https://openalex.org/W7095756747","https://openalex.org/W2058741346"],"abstract_inverted_index":{"ACK":[0,42],"[activated":[1],"Cdc42":[2],"(cell":[3],"division":[4],"cycle":[5],"42)-associated":[6],"tyrosine":[7],"kinase;":[8],"also":[9],"called":[10],"TNK2":[11],"(tyrosine":[12],"kinase,":[13],"non-receptor,":[14],"2)]":[15],"is":[16,83,111,124],"activated":[17],"in":[18,70],"response":[19],"to":[20,151,168],"multiple":[21],"cellular":[22],"signals,":[23],"including":[24],"cell":[25,102,106,127],"adhesion,":[26,103],"growth":[27,66],"factor":[28,67],"receptors":[29],"and":[30,154],"heterotrimeric":[31],"G-protein-coupled":[32],"receptor":[33],"signalling.":[34],"However,":[35],"the":[36,47,55,62,76,93,114,119,131,143,152,159],"molecular":[37,183],"mechanism":[38,184],"underlying":[39,185],"activation":[40,88,97,108,132,172,186],"of":[41,54,75,80,89,92,98,101,109,121,133,145,166,173,187],"remains":[43],"largely":[44],"unclear.":[45],"In":[46,130],"present":[48],"study,":[49],"we":[50,162],"demonstrated":[51],"that":[52,105,164],"interaction":[53,144],"SH3":[56,94],"(Src":[57],"homology":[58],"3)":[59],"domain":[60,95],"with":[61,147],"EBD":[63,153],"[EGFR":[64],"(epidermal":[65],"receptor)-binding":[68],"domain]":[69],"ACK1":[71,110,122,134,146,156],"forms":[72],"an":[73],"auto-inhibition":[74,82],"kinase":[77],"activity.":[78],"Release":[79],"this":[81],"a":[84,181],"key":[85],"step":[86],"for":[87,126],"ACK1.":[90,174,188],"Mutation":[91],"caused":[96,170],"ACK1,":[99],"independent":[100],"suggesting":[104],"adhesion-mediated":[107,128],"through":[112,149],"releasing":[113,158],"auto-inhibition.":[115,160],"A":[116],"region":[117],"at":[118],"N-terminus":[120],"(Leu10-Leu14)":[123],"essential":[125],"activation.":[129],"by":[135,157],"EGFR":[136,148],"signalling,":[137],"Grb2":[138],"(growth-factor-receptor-bound":[139],"protein":[140],"2)":[141],"mediates":[142],"binding":[150],"activates":[155],"Furthermore,":[161],"found":[163],"mutation":[165],"Ser445":[167],"proline":[169],"constitutive":[171],"Taken":[175],"together,":[176],"our":[177],"studies":[178],"have":[179],"revealed":[180],"novel":[182]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
