{"id":"https://openalex.org/W1767513691","doi":null,"title":"Topical antibiotics for acute bacterial conjunctivitis: Cochrane systematic review and meta-analysis update.","display_name":"Topical antibiotics for acute bacterial conjunctivitis: Cochrane systematic review and meta-analysis update.","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W1767513691","mag":"1767513691","pmid":"https://pubmed.ncbi.nlm.nih.gov/16378567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1570513"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:408455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1570513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1570513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026215303","display_name":"Aziz Sheikh","orcid":"https://orcid.org/0000-0001-7022-3056","observed_orcids":["https://orcid.org/0000-0001-7022-3056","https://orcid.org/0000-0002-2479-7283"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aziz Sheikh","raw_affiliation_strings":["Division of Community Health Sciences: GP Section, University of Edinburgh. aziz.sheikh@ed.ac.uk","Division of Community Health Sciences: GP section, University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Community Health Sciences: GP Section, University of Edinburgh. aziz.sheikh@ed.ac.uk","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Community Health Sciences: GP section, University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102738635","display_name":"Brian Hurwitz","orcid":"https://orcid.org/0000-0002-6951-2544","observed_orcids":["https://orcid.org/0000-0002-6951-2544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Hurwitz","raw_affiliation_strings":["English Language & Literature"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"English Language & Literature","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3514,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.74811083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"521","first_page":"962","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-bacterial-conjunctivitis","display_name":"acute bacterial conjunctivitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/topical-antibiotics","display_name":"topical antibiotics","score":1.0},{"id":"https://openalex.org/keywords/chloramphenicol-eye-drops","display_name":"chloramphenicol eye drops","score":0.9940000176429749},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.5590000152587891},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.8920000195503235},{"id":"https://openalex.org/keywords/microbiological-cure","display_name":"microbiological cure","score":0.9279999732971191},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4569999873638153},{"id":"https://openalex.org/keywords/spontaneous-resolution","display_name":"spontaneous resolution","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9033477306365967},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7117660045623779},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6697190999984741},{"id":"https://openalex.org/C2908692415","wikidata":"https://www.wikidata.org/wiki/Q167844","display_name":"Bacterial Conjunctivitis","level":3,"score":0.6478406190872192},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6079130172729492},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6014513969421387},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.510994553565979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5022537708282471},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49276116490364075},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4782470762729645},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3521689176559448},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3428117334842682},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1333998739719391},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07079881429672241},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003234","descriptor_name":"Conjunctivitis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:408455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1570513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16378567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16378567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of general practice : the journal of the Royal College of General Practitioners","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1570513","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1570513/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Gen Pract","raw_type":"Text"},{"id":"mag:1767513691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16378567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:408455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1570513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W102506080","https://openalex.org/W2101673739","https://openalex.org/W2171127049"],"related_works":["https://openalex.org/W102506080","https://openalex.org/W7034399727","https://openalex.org/W4235453801","https://openalex.org/W1976537432","https://openalex.org/W2146867666","https://openalex.org/W2407563662","https://openalex.org/W7053285295","https://openalex.org/W4385065043","https://openalex.org/W2048410749","https://openalex.org/W2900881591"],"abstract_inverted_index":{"BACKGROUND:":[0],"Uncertainty":[1],"remains":[2],"about":[3],"the":[4,29,46,49,75],"extent":[5],"to":[6,45,68,74,141,152,174,188],"which":[7,89,99],"findings":[8],"from":[9],"our":[10,57],"previously":[11],"published":[12],"systematic":[13],"review":[14],"and":[15,65,97,113,143,176],"meta-analysis":[16],"of":[17,22,31,48,111,122,194,209],"double-blind,":[18],"randomised":[19],"controlled":[20],"trials":[21],"topical":[23,119,201],"antibiotics":[24,120,202],"compared":[25],"with":[26,33,94,104,205],"placebo":[27,95,105],"in":[28,38,51,108,124,165],"management":[30,47],"patients":[32],"acute":[34,195],"bacterial":[35,196],"conjunctivitis":[36,197],"treated":[37],"secondary":[39],"care":[40,53,86],"outpatient":[41],"settings":[42],"are":[43,121,180,203],"generalisable":[44],"condition":[50],"primary":[52,85],"settings.":[54],"We":[55],"updated":[56],"review,":[58],"undertaking":[59],"searches,":[60],"methodological":[61],"assessment,":[62],"data":[63,116,159],"extraction":[64],"analysis":[66],"according":[67],"a":[69],"pre-defined":[70],"protocol.":[71],"In":[72],"addition":[73],"previous":[76],"three":[77],"included":[78],"studies,":[79],"we":[80],"identified":[81],"two":[82],"additional":[83],"double-blind":[84],"trials,":[87],"one":[88,98],"compares":[90,100],"fusidic":[91],"acid":[92],"gel":[93,96],"chloramphenicol":[101],"eye":[102,106],"drops":[103,107],"children.":[109],"Meta-analyses":[110],"clinical":[112,129,166,213],"microbiological":[114,144,177],"remission":[115,154,221],"reveal":[117,160],"that":[118,161],"benefit":[123,216],"improving":[125],"early":[126,163,210],"(days":[127,157,211,222],"2-5)":[128,212],"(relative":[130],"risk":[131],"[RR]":[132],"=":[133,139,146,150,168,172,186],"1.24,":[134],"95%":[135,148,170,184],"confidence":[136],"interval":[137],"[CI]":[138],"1.05":[140],"1.45)":[142],"(RR":[145,167,182],"1.77,":[147],"CI":[149,171,185],"1.23":[151],"2.54)":[153],"rates;":[155],"later":[156,220],"6-10)":[158],"these":[162],"advantages":[164],"1.11,":[169],"1.02":[173],"1.21)":[175],"cure":[178],"rates":[179,208],"reduced":[181],"1.56,":[183],"1.17":[187],"2.09),":[189],"but":[190],"persist.":[191],"Most":[192],"cases":[193],"resolve":[198],"spontaneously.":[199],"While":[200],"associated":[204],"significantly":[206],"improved":[207],"remission,":[214],"this":[215],"is":[217],"marginal":[218],"for":[219],"6-10).":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}