{"id":"https://openalex.org/W17662013","doi":"https://doi.org/10.1023/a:1005518523095","title":"Activated Neutrophils Impair Gastric Cytoprotection: Role of Neutrophil Elastase","display_name":"Activated Neutrophils Impair Gastric Cytoprotection: Role of Neutrophil Elastase","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W17662013","doi":"https://doi.org/10.1023/a:1005518523095","mag":"17662013","pmid":"https://pubmed.ncbi.nlm.nih.gov/10877239"},"language":"en","primary_location":{"id":"doi:10.1023/a:1005518523095","doi":"https://doi.org/10.1023/a:1005518523095","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1005518523095","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113569181","display_name":"Naoaki Harada","orcid":"https://orcid.org/0009-0006-6259-0132","observed_orcids":["https://orcid.org/0009-0006-6259-0132"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoaki Harada","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070002300","display_name":"Kenji Okajima","orcid":"https://orcid.org/0000-0001-8311-0077","observed_orcids":["https://orcid.org/0000-0001-8311-0077"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Okajima","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101756334","display_name":"Wenge Liu","orcid":"https://orcid.org/0000-0002-4780-7253","observed_orcids":["https://orcid.org/0000-0002-4780-7253"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wenge Liu","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081500257","display_name":"Mitsuhiro Uchiba","orcid":"https://orcid.org/0000-0003-3377-4216","observed_orcids":["https://orcid.org/0000-0003-3377-4216"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Uchiba","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.2634,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.80467615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"6","first_page":"1210","last_page":"1216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gastric-cytoprotection","display_name":"gastric cytoprotection","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.796999990940094},{"id":"https://openalex.org/keywords/6-keto-pgf1alpha","display_name":"6-keto-PGF1 alpha","score":0.9150000214576721},{"id":"https://openalex.org/keywords/stress-induced-gastric-mucosal-injury","display_name":"stress-induced gastric mucosal injury","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gastric-mucosal-blood-flow","display_name":"gastric mucosal blood flow","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neutrophil-elastase-inhibitor","display_name":"neutrophil elastase inhibitor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ono-5046","display_name":"ONO-5046","score":0.8849999904632568},{"id":"https://openalex.org/keywords/eglin-c","display_name":"eglin C","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.7479427456855774},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.7375840544700623},{"id":"https://openalex.org/C2909339193","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Transplant surgery","level":3,"score":0.7112047076225281},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.6691188812255859},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.66845703125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6033141613006592},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5933713912963867},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.5032278895378113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4128949046134949},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40860050916671753},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.406015545129776},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3326886296272278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20121675729751587},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.1710081696510315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12028026580810547},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11041268706321716}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007101","descriptor_name":"Immersion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013272","descriptor_name":"Stomach Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013272","descriptor_name":"Stomach Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013272","descriptor_name":"Stomach Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015121","descriptor_name":"6-Ketoprostaglandin F1 alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1005518523095","doi":"https://doi.org/10.1023/a:1005518523095","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1005518523095","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},{"id":"pmid:10877239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10877239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases and sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W21067786","https://openalex.org/W248321605","https://openalex.org/W1647673633","https://openalex.org/W1818240045","https://openalex.org/W1974913500","https://openalex.org/W1975508974","https://openalex.org/W1984988604","https://openalex.org/W1988456139","https://openalex.org/W1989986582","https://openalex.org/W1992314913","https://openalex.org/W1996337788","https://openalex.org/W1997118728","https://openalex.org/W1999063996","https://openalex.org/W1999083451","https://openalex.org/W2004814340","https://openalex.org/W2007254610","https://openalex.org/W2018813114","https://openalex.org/W2021320823","https://openalex.org/W2029134608","https://openalex.org/W2032758359","https://openalex.org/W2036682175","https://openalex.org/W2039697569","https://openalex.org/W2048249323","https://openalex.org/W2052327108","https://openalex.org/W2053046219","https://openalex.org/W2062874559","https://openalex.org/W2084971617","https://openalex.org/W2086520388","https://openalex.org/W2088400812","https://openalex.org/W2109272101","https://openalex.org/W2122340134","https://openalex.org/W2130244415","https://openalex.org/W2132925738","https://openalex.org/W2135515147","https://openalex.org/W2153470540","https://openalex.org/W2156953890","https://openalex.org/W2290055592","https://openalex.org/W2410174541","https://openalex.org/W2412217380","https://openalex.org/W2474978114"],"related_works":["https://openalex.org/W2044252321","https://openalex.org/W2431600337","https://openalex.org/W2021320823","https://openalex.org/W1984988604","https://openalex.org/W2027622792","https://openalex.org/W1996337788","https://openalex.org/W1986924856","https://openalex.org/W67258670","https://openalex.org/W187703564","https://openalex.org/W2081192807"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}