{"id":"https://openalex.org/W1765210549","doi":"https://doi.org/10.4049/jimmunol.1102859","title":"Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival","display_name":"Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival","publication_year":2012,"publication_date":"2012-03-10","ids":{"openalex":"https://openalex.org/W1765210549","doi":"https://doi.org/10.4049/jimmunol.1102859","mag":"1765210549","pmid":"https://pubmed.ncbi.nlm.nih.gov/22407922"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1102859","doi":"https://doi.org/10.4049/jimmunol.1102859","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1102859","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056479977","display_name":"Kaiissar Mannoor","orcid":"https://orcid.org/0000-0002-2394-0447","observed_orcids":["https://orcid.org/0000-0002-2394-0447"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kaiissar Mannoor","raw_affiliation_strings":["Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044203787","display_name":"Agata Matejuk","orcid":"https://orcid.org/0000-0003-2671-7707","observed_orcids":["https://orcid.org/0000-0003-2671-7707"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Agata Matejuk","raw_affiliation_strings":["Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yang Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["Central South University, Second Xiangya Hospital , Changsha 410011 ,","\u2020Central South University, Second Xiangya Hospital, Changsha 410011, China; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University, Second Xiangya Hospital , Changsha 410011 ,","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]},{"raw_affiliation_string":"\u2020Central South University, Second Xiangya Hospital, Changsha 410011, China; and","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044144189","display_name":"Michael K. Beardall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Beardall","raw_affiliation_strings":["\u2021Department of Pathology, Oregon Health & Science University, Portland, OR 97239"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Department of Pathology, Oregon Health & Science University, Portland, OR 97239","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060345558","display_name":"Ching Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ching Chen","raw_affiliation_strings":["Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044203787","https://openalex.org/A5056479977","https://openalex.org/A5060345558"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.6833,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94659121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"188","issue":"8","first_page":"3628","last_page":"3638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-autoantibodies","display_name":"natural autoantibodies","score":1.0},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mrl-lpr-mice","display_name":"MRL/lpr mice","score":0.8569999933242798},{"id":"https://openalex.org/keywords/autoantibody-producing-b-cells","display_name":"autoantibody-producing B cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.5849999785423279},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tlr-stimulation","display_name":"TLR stimulation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.847960352897644},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6935872435569763},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6418445110321045},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5773038268089294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5689823627471924},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.5560970902442932},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5503114461898804},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.43168550729751587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.416251540184021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39828142523765564},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37930476665496826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34239649772644043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32061105966567993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25485146045684814},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17148339748382568}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017578","descriptor_name":"Immunoglobulin Class Switching","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019463","descriptor_name":"Mice, Inbred MRL lpr","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.1102859","doi":"https://doi.org/10.4049/jimmunol.1102859","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1102859","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:22407922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22407922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.981.6481","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.981.6481","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Ching_Chen9/publication/221693908_Expression_of_natural_autoantibodies_in_MRL-lpr_mice_protects_from_lupus_nephritis_and_improves_survival/links/54d3913f0cf2501791824f06.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326846","display_name":"State Key Laboratory of Polymer Physics and Chemistry","ror":"https://ror.org/05vy7se14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1481521731","https://openalex.org/W1482494509","https://openalex.org/W1498105805","https://openalex.org/W1508918383","https://openalex.org/W1513332086","https://openalex.org/W1517617266","https://openalex.org/W1520294975","https://openalex.org/W1528942387","https://openalex.org/W1541258859","https://openalex.org/W1543086249","https://openalex.org/W1547450219","https://openalex.org/W1552738427","https://openalex.org/W1554784279","https://openalex.org/W1562717001","https://openalex.org/W1564692715","https://openalex.org/W1568395771","https://openalex.org/W1573250191","https://openalex.org/W1597017834","https://openalex.org/W1603713705","https://openalex.org/W1626010195","https://openalex.org/W1673783711","https://openalex.org/W1882149925","https://openalex.org/W1964701274","https://openalex.org/W1965672602","https://openalex.org/W1966949480","https://openalex.org/W1974440177","https://openalex.org/W1975305530","https://openalex.org/W1980082178","https://openalex.org/W1996081003","https://openalex.org/W1998649840","https://openalex.org/W2001710332","https://openalex.org/W2002073873","https://openalex.org/W2011617127","https://openalex.org/W2014365674","https://openalex.org/W2016208323","https://openalex.org/W2017845501","https://openalex.org/W2020248106","https://openalex.org/W2025412364","https://openalex.org/W2025591085","https://openalex.org/W2034708798","https://openalex.org/W2035806483","https://openalex.org/W2039919570","https://openalex.org/W2048072167","https://openalex.org/W2048730062","https://openalex.org/W2051729351","https://openalex.org/W2054909644","https://openalex.org/W2057728325","https://openalex.org/W2065189089","https://openalex.org/W2065260129","https://openalex.org/W2066685783","https://openalex.org/W2067185719","https://openalex.org/W2067217824","https://openalex.org/W2068894321","https://openalex.org/W2077297620","https://openalex.org/W2080678103","https://openalex.org/W2081008050","https://openalex.org/W2086946925","https://openalex.org/W2088984791","https://openalex.org/W2091303626","https://openalex.org/W2095741007","https://openalex.org/W2096591517","https://openalex.org/W2100566421","https://openalex.org/W2104087345","https://openalex.org/W2108623794","https://openalex.org/W2109191041","https://openalex.org/W2111940985","https://openalex.org/W2119938531","https://openalex.org/W2125867015","https://openalex.org/W2127132484","https://openalex.org/W2127321441","https://openalex.org/W2134106169","https://openalex.org/W2134544592","https://openalex.org/W2135943092","https://openalex.org/W2140582776","https://openalex.org/W2141301927","https://openalex.org/W2142421920","https://openalex.org/W2148706075","https://openalex.org/W2155142844","https://openalex.org/W2157721335","https://openalex.org/W2162928156","https://openalex.org/W2167318411","https://openalex.org/W2168460037","https://openalex.org/W2168516002","https://openalex.org/W2227157639","https://openalex.org/W2415271946","https://openalex.org/W2436681461","https://openalex.org/W6715870953"],"related_works":["https://openalex.org/W21404724","https://openalex.org/W119863360","https://openalex.org/W936888189","https://openalex.org/W2013873712","https://openalex.org/W2052291973","https://openalex.org/W2077310069","https://openalex.org/W1988917752","https://openalex.org/W2125867015","https://openalex.org/W2149370446","https://openalex.org/W2065700623"],"abstract_inverted_index":{"Natural":[0],"autoantibodies":[1],"(NAA)":[2],"and":[3,16,34,63,88,127,141,168,199,212],"their":[4],"associated":[5],"B":[6,17,65,184,201,217],"cells":[7,66,153,185,202,218],"constitute":[8],"a":[9,26,54,132],"substantial":[10],"proportion":[11],"of":[12,28,61,81,101,112,121,162,171,189,228],"the":[13,59,71,79,102,110,135,146,155,163,178,182,215,226],"normal":[14],"Ab":[15],"cell":[18],"repertoire.":[19],"They":[20],"often":[21],"have":[22,220],"weak":[23],"reactivity":[24],"toward":[25],"variety":[27],"self-Ags":[29],"such":[30],"as":[31,173],"DNA,":[32],"nucleoproteins,":[33],"phospholipids.":[35],"It":[36],"remains":[37],"controversial":[38],"whether":[39],"NAA":[40,62,82,104,183,198,216],"contribute":[41],"to":[42,105,143],"or":[43],"protect":[44],"from":[45,139,154,177,209],"autoimmune":[46],"diseases.":[47],"Using":[48],"site-directed":[49],"transgenic":[50],"(sd-tg)":[51],"mice":[52,85,95,107,117,158],"expressing":[53],"prototypic":[55],"NAA,":[56],"we":[57],"investigated":[58],"effect":[60],"NAA-producing":[64,200],"in":[67,70,83,134,145,207],"disease":[68],"development":[69],"autoimmune-prone":[72],"MRL/MpJ-Fas(lpr)":[73],"(MRL-lpr)":[74],"mice.":[75,149,180],"We":[76],"found":[77],"that":[78,197,214],"expression":[80,161],"MRL-lpr":[84,106,116,148,157],"prevented":[86],"proteinuria":[87],"reduced":[89],"kidney":[90],"immune":[91,222],"complex":[92],"formation.":[93],"The":[94,114,150],"had":[96,118,159],"significantly":[97],"improved":[98],"survival.":[99],"Administration":[100],"IgM":[103],"also":[108],"delayed":[109],"onset":[111],"nephritis.":[113],"sd-tg":[115,147,156],"decreased":[119],"levels":[120],"anti-dsDNA":[122],"Abs,":[123,126],"anti-Hep2":[124],"nuclear":[125],"anti-Sm/ribonucleoprotein":[128],"Abs.":[129],"There":[130],"is":[131],"shift":[133],"IgG":[136],"subclass":[137],"profile":[138],"IgG2a":[140],"IgG3":[142],"IgG1":[144],"CD4(+)":[151],"T":[152],"increased":[160,169],"negative":[164],"costimulatory":[165],"molecule":[166],"CTLA-4":[167],"production":[170],"IL-10":[172,190],"compared":[174],"with":[175],"those":[176],"wild-type":[179],"Furthermore,":[181],"produced":[186],"large":[187],"amounts":[188],"upon":[191],"TLR":[192],"stimulation.":[193],"These":[194],"results":[195],"indicate":[196],"play":[203],"an":[204,221],"important":[205],"role":[206],"protection":[208],"lupus":[210],"nephritis":[211],"suggest":[213],"may":[219],"regulatory":[223],"function":[224],"via":[225],"provision":[227],"IL-10.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}