{"id":"https://openalex.org/W1764907397","doi":null,"title":"Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis","display_name":"Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1764907397","mag":"1764907397"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:df1ca3fd-b33c-4462-a170-97eee9bad915","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1689759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/1689759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038593464","display_name":"Mohamed Abdgawad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohamed Abdgawad","raw_affiliation_strings":["Nephrology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038593464"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-apoptosis","display_name":"neutrophil apoptosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/proteinase-3","display_name":"proteinase 3","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cd177","display_name":"CD177","score":0.9020000100135803},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.902999997138977},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":1.0},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neutrophil-phenotype","display_name":"neutrophil phenotype","score":0.7799999713897705},{"id":"https://openalex.org/keywords/antineutrophil-cytoplasmic-antibodies","display_name":"antineutrophil cytoplasmic antibodies","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7031986713409424},{"id":"https://openalex.org/C21194631","wikidata":"https://www.wikidata.org/wiki/Q2113501","display_name":"Proteinase 3","level":4,"score":0.6710218787193298},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.6292983889579773},{"id":"https://openalex.org/C2777374719","wikidata":"https://www.wikidata.org/wiki/Q7663822","display_name":"Systemic vasculitis","level":4,"score":0.5950256586074829},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5157387852668762},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4907930791378021},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.459299236536026},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4215434491634369},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.41116997599601746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37864553928375244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36917340755462646},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33053937554359436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30587226152420044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30200839042663574},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.13240036368370056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06527668237686157},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:df1ca3fd-b33c-4462-a170-97eee9bad915","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1689759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1764907397","doi":null,"is_oa":false,"landing_page_url":"https://lucris.lub.lu.se/ws/files/4150475/1689761.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:df1ca3fd-b33c-4462-a170-97eee9bad915","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1689759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W101685622","https://openalex.org/W156988113","https://openalex.org/W249585176","https://openalex.org/W1502074492","https://openalex.org/W1508779802","https://openalex.org/W1597610606","https://openalex.org/W1850336480","https://openalex.org/W1862138102","https://openalex.org/W1966999651","https://openalex.org/W1970435671","https://openalex.org/W1973752319","https://openalex.org/W1978918614","https://openalex.org/W1979473901","https://openalex.org/W1980568348","https://openalex.org/W1990143710","https://openalex.org/W1992584670","https://openalex.org/W1995126840","https://openalex.org/W2004048460","https://openalex.org/W2011865156","https://openalex.org/W2011881258","https://openalex.org/W2023004400","https://openalex.org/W2028139634","https://openalex.org/W2029523355","https://openalex.org/W2041062474","https://openalex.org/W2046973704","https://openalex.org/W2048209972","https://openalex.org/W2048633827","https://openalex.org/W2057650268","https://openalex.org/W2059378490","https://openalex.org/W2067355922","https://openalex.org/W2071558773","https://openalex.org/W2074493537","https://openalex.org/W2080619054","https://openalex.org/W2081023797","https://openalex.org/W2095750011","https://openalex.org/W2098605310","https://openalex.org/W2100017299","https://openalex.org/W2100505646","https://openalex.org/W2107254198","https://openalex.org/W2117466115","https://openalex.org/W2118094114","https://openalex.org/W2118825676","https://openalex.org/W2126289275","https://openalex.org/W2130911389","https://openalex.org/W2132141878","https://openalex.org/W2137676749","https://openalex.org/W2141225393","https://openalex.org/W2146145282","https://openalex.org/W2153013281","https://openalex.org/W2153853402","https://openalex.org/W2161743101","https://openalex.org/W2161846961","https://openalex.org/W2162725007","https://openalex.org/W2166150794","https://openalex.org/W2170898599","https://openalex.org/W2264075806","https://openalex.org/W2276542749","https://openalex.org/W2318254613","https://openalex.org/W2338701494","https://openalex.org/W2502895879","https://openalex.org/W2902766594","https://openalex.org/W4298880977","https://openalex.org/W4299336602"],"related_works":["https://openalex.org/W2022415296","https://openalex.org/W1979473901","https://openalex.org/W1794404623","https://openalex.org/W2418197144","https://openalex.org/W2011881258","https://openalex.org/W6940336950","https://openalex.org/W1974091863","https://openalex.org/W2136706032","https://openalex.org/W2012227212","https://openalex.org/W2514104832"],"abstract_inverted_index":{"ANCA-Associated":[0],"Systemic":[1],"Vasculitis":[2],"(AASV)":[3],"is":[4,195,203,232],"characterized":[5],"by":[6,34,41,50,56,76],"leukocytoclasis-":[7],"dying":[8,212],"neutrophils":[9,25,99,128,137,171,213],"surrounding":[10],"small":[11],"blood":[12,140],"vessels.":[13],"Previous":[14],"studies":[15,221],"have":[16],"shown":[17],"increased":[18,22],"plasma":[19,27,152],"PR3":[20,29,113,115],"and":[21,36,46,67,72,82,91,103,165,188,237],"proportion":[23,83],"of":[24,64,84,98,123,134,160,193,200,211,216,229,240],"expressing":[26],"membrane-associated":[28],"(mPR3+).":[30],"Neutrophils":[31],"were":[32,48,86,93,167],"isolated":[33],"polymorphprep":[35],"membrane":[37],"expression":[38,106,157],"was":[39,54,74,107,119],"measured":[40,49,55,75],"FACS.":[42],"Plasma":[43,79],"PR3,":[44,80,153],"pro-PR3":[45],"cytokines":[47],"ELISA.":[51],"Neutrophil":[52],"apoptosis":[53,135,144,202,231,242],"FACS":[57],"after":[58],"20h":[59],"in":[60,88,101,170,176,186,214,218,234],"vitro":[61],"culture.":[62],"Expression":[63],"pro/anti-apoptotic":[65,161],"factors":[66,69],"transcription":[68,122],"C/EBP-\u03b1,":[70],"C/EBP-\u03b2":[71,166],"PU.1":[73],"real-time":[77],"PCR.":[78],"pro-PR3,":[81],"mPR3+neutrophils":[85],"elevated":[87],"AASV.":[89,219],"mPR3":[90,105,156],"CD177":[92,125],"co-expressed":[94],"on":[95,121],"a":[96,130],"subset":[97],"both":[100],"AASV":[102,127,173,187,235],"controls.":[104],"not":[108,147],"correlated":[109],"directly":[110,244],"to":[111,224,245],"circulating":[112],"or":[114,158],"gene":[116],"transcription,":[117],"but":[118],"dependent":[120],"the":[124,191,198,209,227,246],"gene.":[126],"had":[129],"significantly":[131,168],"lower":[132,233],"rate":[133,145,192,199,228],"than":[136,175],"from":[138,172],"healthy":[139],"donors":[141],"(HBD).":[142],"Lower":[143],"did":[146],"correlate":[148],"with":[149],"clinical":[150],"data,":[151],"cytokine":[154],"levels,":[155],"level":[159],"factors.":[162],"However,":[163],"C/EBP-\u03b1":[164],"higher":[169],"patients":[174,236],"HBD":[177],"neutrophils.":[178],"These":[179],"results":[180],"indicate":[181],"an":[182],"altered":[183],"neutrophil":[184,201,230,241],"phenotype":[185],"suggest":[189],"that":[190],"granulopoiesis":[194],"higher,":[196],"while":[197],"lower.":[204],"This":[205],"may":[206],"predispose":[207],"for":[208],"presence":[210],"regions":[215],"inflammation":[217],"Additional":[220],"are":[222],"required":[223],"determine":[225],"why":[226],"if":[238],"dysregulation":[239],"contributes":[243],"pathogenesis.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
