{"id":"https://openalex.org/W1763805809","doi":"https://doi.org/10.1042/bj3230001","title":"Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling","display_name":"Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W1763805809","doi":"https://doi.org/10.1042/bj3230001","mag":"1763805809","pmid":"https://pubmed.ncbi.nlm.nih.gov/9173866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1218279"},"language":"en","primary_location":{"id":"doi:10.1042/bj3230001","doi":"https://doi.org/10.1042/bj3230001","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3230001","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1218279/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041757990","display_name":"Nils Joakim F\u00e6rgeman","orcid":"https://orcid.org/0000-0002-9281-5287","observed_orcids":["https://orcid.org/0000-0002-9281-5287"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nils Joakim F\u00c6RGEMAN","raw_affiliation_strings":["Institute of Biochemistry, Odense University, DK-5230 Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Odense University, DK-5230 Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113435937","display_name":"Jens Knudsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens KNUDSEN","raw_affiliation_strings":["Institute of Biochemistry, Odense University, DK-5230 Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Odense University, DK-5230 Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177969490"],"apc_list":null,"apc_paid":null,"fwci":13.6754,"has_fulltext":false,"cited_by_count":688,"citation_normalized_percentile":{"value":0.99699893,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"323","issue":"1","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.3361999988555908,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-synthetase","display_name":"acyl-CoA synthetase","score":0.765999972820282},{"id":"https://openalex.org/keywords/acyl-coa-binding-protein","display_name":"acyl-CoA binding protein","score":0.9480000138282776},{"id":"https://openalex.org/keywords/acylcarnitines","display_name":"acylcarnitines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/acyl-coa-hydrolase","display_name":"acyl-CoA hydrolase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.968999981880188},{"id":"https://openalex.org/keywords/fatty-acid-synthesis-regulation","display_name":"fatty acid synthesis regulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/fatty-acid-desaturase","display_name":"fatty acid desaturase","score":0.6370000243186951},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2779685201","wikidata":"https://www.wikidata.org/wiki/Q2699537","display_name":"Acyl-CoA","level":3,"score":0.8054928183555603},{"id":"https://openalex.org/C2779318131","wikidata":"https://www.wikidata.org/wiki/Q21199067","display_name":"Acetyl-CoA carboxylase","level":4,"score":0.7091100215911865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7054209113121033},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.6954137682914734},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5288537740707397},{"id":"https://openalex.org/C2778470496","wikidata":"https://www.wikidata.org/wiki/Q715317","display_name":"Acetyl-CoA","level":3,"score":0.5173448920249939},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5065056085586548},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47237423062324524},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.47152504324913025},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4654539227485657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4428150951862335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38073334097862244}],"mesh":[{"descriptor_ui":"D000071438","descriptor_name":"Fatty Acid-Binding Protein 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018996","descriptor_name":"Myelin P2 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026261","descriptor_name":"Diazepam Binding Inhibitor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj3230001","doi":"https://doi.org/10.1042/bj3230001","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3230001","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:9173866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9173866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1218279","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1218279/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/e7410c7f-18fa-49fc-b045-2a27f5b17c50","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/e7410c7f-18fa-49fc-b045-2a27f5b17c50","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F\u00e6rgeman, N J & Knudsen, J 1997, 'Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling', Biochemical Journal, vol. 323, no. 1, pp. 1-12. https://doi.org/10.1042/bj3230001","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1218279","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1218279/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":174,"referenced_works":["https://openalex.org/W4888166","https://openalex.org/W13114764","https://openalex.org/W27725037","https://openalex.org/W36236453","https://openalex.org/W72022277","https://openalex.org/W102865737","https://openalex.org/W113204805","https://openalex.org/W119601619","https://openalex.org/W125791290","https://openalex.org/W142315095","https://openalex.org/W144514460","https://openalex.org/W147079412","https://openalex.org/W156869561","https://openalex.org/W162638266","https://openalex.org/W172225603","https://openalex.org/W192089870","https://openalex.org/W198117553","https://openalex.org/W203292102","https://openalex.org/W211405958","https://openalex.org/W327214130","https://openalex.org/W1479945388","https://openalex.org/W1480025162","https://openalex.org/W1495212988","https://openalex.org/W1495601548","https://openalex.org/W1498234043","https://openalex.org/W1499384204","https://openalex.org/W1509209316","https://openalex.org/W1509236900","https://openalex.org/W1512193446","https://openalex.org/W1524798848","https://openalex.org/W1529045066","https://openalex.org/W1541062598","https://openalex.org/W1561135914","https://openalex.org/W1567146796","https://openalex.org/W1586410777","https://openalex.org/W1587612554","https://openalex.org/W1589541819","https://openalex.org/W1591547152","https://openalex.org/W1592623275","https://openalex.org/W1624705676","https://openalex.org/W1661605701","https://openalex.org/W1673932087","https://openalex.org/W1750774965","https://openalex.org/W1753518855","https://openalex.org/W1760626668","https://openalex.org/W1805611945","https://openalex.org/W1820688811","https://openalex.org/W1825429543","https://openalex.org/W1832755122","https://openalex.org/W1843016560","https://openalex.org/W1846979937","https://openalex.org/W1875164239","https://openalex.org/W1920455748","https://openalex.org/W1964481352","https://openalex.org/W1968182352","https://openalex.org/W1969968393","https://openalex.org/W1972240339","https://openalex.org/W1974835689","https://openalex.org/W1976702450","https://openalex.org/W1977263736","https://openalex.org/W1980057782","https://openalex.org/W1983529996","https://openalex.org/W1984405096","https://openalex.org/W1985132952","https://openalex.org/W1986141793","https://openalex.org/W1988533635","https://openalex.org/W1988913595","https://openalex.org/W1989095625","https://openalex.org/W1990186318","https://openalex.org/W1991328593","https://openalex.org/W1995129162","https://openalex.org/W1996649880","https://openalex.org/W1998222131","https://openalex.org/W2001915050","https://openalex.org/W2002173318","https://openalex.org/W2002566107","https://openalex.org/W2006051351","https://openalex.org/W2006148130","https://openalex.org/W2008264122","https://openalex.org/W2009240157","https://openalex.org/W2012611035","https://openalex.org/W2013708699","https://openalex.org/W2015885841","https://openalex.org/W2017272722","https://openalex.org/W2017711362","https://openalex.org/W2018562021","https://openalex.org/W2022336683","https://openalex.org/W2023500217","https://openalex.org/W2025264195","https://openalex.org/W2028532022","https://openalex.org/W2031107810","https://openalex.org/W2031616683","https://openalex.org/W2033823674","https://openalex.org/W2035653643","https://openalex.org/W2036297968","https://openalex.org/W2037209806","https://openalex.org/W2038173608","https://openalex.org/W2038874419","https://openalex.org/W2039215531","https://openalex.org/W2039531356","https://openalex.org/W2040606975","https://openalex.org/W2041930949","https://openalex.org/W2044082167","https://openalex.org/W2044203611","https://openalex.org/W2045173278","https://openalex.org/W2045201964","https://openalex.org/W2046391592","https://openalex.org/W2047659321","https://openalex.org/W2047690587","https://openalex.org/W2047899898","https://openalex.org/W2048278170","https://openalex.org/W2050445974","https://openalex.org/W2052433752","https://openalex.org/W2052855600","https://openalex.org/W2053063647","https://openalex.org/W2054128789","https://openalex.org/W2054805984","https://openalex.org/W2056249844","https://openalex.org/W2056541157","https://openalex.org/W2059867106","https://openalex.org/W2060784291","https://openalex.org/W2061827995","https://openalex.org/W2067130241","https://openalex.org/W2070584189","https://openalex.org/W2071103249","https://openalex.org/W2071799745","https://openalex.org/W2071941416","https://openalex.org/W2075574260","https://openalex.org/W2075973642","https://openalex.org/W2077798389","https://openalex.org/W2083007053","https://openalex.org/W2083847273","https://openalex.org/W2087434550","https://openalex.org/W2089093690","https://openalex.org/W2090550715","https://openalex.org/W2090585484","https://openalex.org/W2092145433","https://openalex.org/W2096135945","https://openalex.org/W2097540828","https://openalex.org/W2100878049","https://openalex.org/W2103440968","https://openalex.org/W2106141363","https://openalex.org/W2108164920","https://openalex.org/W2108315606","https://openalex.org/W2113152093","https://openalex.org/W2121048884","https://openalex.org/W2126075295","https://openalex.org/W2127749354","https://openalex.org/W2143079633","https://openalex.org/W2148480887","https://openalex.org/W2152420113","https://openalex.org/W2160134374","https://openalex.org/W2167411606","https://openalex.org/W2173424827","https://openalex.org/W2177231190","https://openalex.org/W2205725476","https://openalex.org/W2212061062","https://openalex.org/W2218148748","https://openalex.org/W2242477415","https://openalex.org/W2263213162","https://openalex.org/W2271727959","https://openalex.org/W2301037150","https://openalex.org/W2330754142","https://openalex.org/W2336686047","https://openalex.org/W2340951843","https://openalex.org/W2396890980","https://openalex.org/W2406232887","https://openalex.org/W2409255115","https://openalex.org/W2411074224","https://openalex.org/W2413938035","https://openalex.org/W2438417438","https://openalex.org/W2464677741","https://openalex.org/W3156406877","https://openalex.org/W4231733340"],"related_works":["https://openalex.org/W1594915831","https://openalex.org/W2166176072","https://openalex.org/W2163311677","https://openalex.org/W7140526202","https://openalex.org/W1910635175","https://openalex.org/W2411074224","https://openalex.org/W1579596229","https://openalex.org/W2020433831","https://openalex.org/W2062644914","https://openalex.org/W2082589024"],"abstract_inverted_index":{"The":[0,77],"intracellular":[1],"concentration":[2,30,53,101],"of":[3,14,54,113,120,138,145,147,172,176,201,230],"free":[4,51,98],"unbound":[5],"acyl-CoA":[6,16,23,44,55,90,100,121,167,177,202,206,239],"esters":[7,56,168,207],"is":[8,19,66,82,91,102,151,163,217],"tightly":[9],"controlled":[10],"by":[11,21,36,41,43,165,197,220],"feedback":[12],"inhibition":[13],"the":[15,29,50,60,73,97,114,118,136,139,148,156,159,170,184,189,221],"synthetase":[17],"and":[18,64,125,180,188],"buffered":[20],"specific":[22],"binding":[24,142,178],"proteins.":[25,143],"Excessive":[26],"increases":[27],"in":[28,59,135,169,213,235,238],"are":[31,195],"expected":[32],"to":[33,68],"be":[34,58],"prevented":[35],"conversion":[37],"into":[38],"acylcarnitines":[39],"or":[40,233],"hydrolysis":[42],"hydrolases.":[45],"Under":[46],"normal":[47],"physiological":[48,133],"conditions":[49],"cytosolic":[52,99],"will":[57],"low":[61,132,198],"nanomolar":[62,199],"range,":[63],"it":[65],"unlikely":[67],"exceed":[69],"200":[70],"nM":[71,105],"under":[72,106],"most":[74],"extreme":[75],"conditions.":[76,108],"fact":[78],"that":[79,96,158,181,204,223],"acetyl-CoA":[80,182,231],"carboxylase":[81,232],"active":[83],"during":[84],"fatty":[85,224],"acid":[86],"synthesis":[87],"(Ki":[88],"for":[89],"5":[92,104],"nM)":[93],"indicates":[94],"strongly":[95],"below":[103],"these":[107],"Only":[109],"a":[110,173],"limited":[111],"number":[112],"reported":[115,149],"experiments":[116],"on":[117,122],"effects":[119,150],"cellular":[123],"functions":[124],"enzymes":[126],"have":[127],"been":[128],"carried":[129],"out":[130],"at":[131],"concentrations":[134,200],"presence":[137,171],"appropriate":[140],"acyl-CoA-buffering":[141],"Re-evaluation":[144],"many":[146],"therefore":[152],"urgently":[153],"required.":[154],"However,":[155],"observations":[157],"ryanodine-senstitive":[160],"Ca2+-release":[161],"channel":[162],"regulated":[164],"long-chain":[166,205],"molar":[174],"excess":[175],"protein":[179],"carboxylase,":[183],"AMP":[185],"kinase":[186,187],"Escherichia":[190],"coli":[191],"transcription":[192],"factor":[193],"FadR":[194],"affected":[196],"indicate":[203],"can":[208],"act":[209],"as":[210],"regulatory":[211],"molecules":[212],"vivo.":[214],"This":[215],"view":[216],"further":[218],"supported":[219],"observation":[222],"acids":[225],"do":[226],"not":[227],"repress":[228],"expression":[229],"Delta9-desaturase":[234],"yeast":[236],"deficient":[237],"synthetase.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}