{"id":"https://openalex.org/W176299968","doi":null,"title":"Calponin distribution in human ciliary muscle and other anterior segment tissues.","display_name":"Calponin distribution in human ciliary muscle and other anterior segment tissues.","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W176299968","mag":"176299968","pmid":"https://pubmed.ncbi.nlm.nih.gov/9040467"},"language":"en","primary_location":{"id":"pmid:9040467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026360034","display_name":"Kenji Kashiwagi","orcid":"https://orcid.org/0000-0001-8506-8503","observed_orcids":["https://orcid.org/0000-0001-8506-8503"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Kashiwagi","raw_affiliation_strings":["Glaucoma Center, University of California, San Diego, La Jolla 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California, San Diego, La Jolla 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113499622","display_name":"James D. Lindsey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Lindsey","raw_affiliation_strings":["Glaucoma Center, University of California, San Diego, La Jolla 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California, San Diego, La Jolla 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083809845","display_name":"Fumiko Kashiwagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Kashiwagi","raw_affiliation_strings":["Glaucoma Center, University of California, San Diego, La Jolla 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California, San Diego, La Jolla 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067018069","display_name":"Shigeo Tsukahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Tsukahara","raw_affiliation_strings":["Glaucoma Center, University of California, San Diego, La Jolla 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California, San Diego, La Jolla 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043994887","display_name":"Robert Neal Weinreb","orcid":"https://orcid.org/0000-0001-9553-3202","observed_orcids":["https://orcid.org/0000-0001-9553-3202","https://orcid.org/0000-0003-4217-4853"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Weinreb","raw_affiliation_strings":["Glaucoma Center, University of California, San Diego, La Jolla 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Center, University of California, San Diego, La Jolla 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.4784,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54227839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"38","issue":"2","first_page":"349","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.2134000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.2134000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calponin","display_name":"calponin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ciliary-muscle","display_name":"ciliary muscle","score":0.972000002861023},{"id":"https://openalex.org/keywords/anterior-eye-segment","display_name":"anterior segment of the eye","score":0.7519999742507935},{"id":"https://openalex.org/keywords/iris-dilator-muscle","display_name":"iris dilator muscle","score":0.8939999938011169},{"id":"https://openalex.org/keywords/iris-sphincter-muscle","display_name":"iris sphincter","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scleral-spur","display_name":"scleral spur","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.902999997138977},{"id":"https://openalex.org/keywords/tenon-fibroblasts","display_name":"Tenon fibroblasts","score":0.9419999718666077},{"id":"https://openalex.org/keywords/actin-binding-proteins","display_name":"actin-binding proteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2781122658","wikidata":"https://www.wikidata.org/wiki/Q24744812","display_name":"Calponin","level":3,"score":0.9777849912643433},{"id":"https://openalex.org/C2780718027","wikidata":"https://www.wikidata.org/wiki/Q239972","display_name":"Ciliary muscle","level":3,"score":0.8323579430580139},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.7892581224441528},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5460269451141357},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.5211039781570435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4939938187599182},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.46132177114486694},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4609644114971161},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4437122344970703},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3917003870010376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35378503799438477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2283019721508026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1531616449356079},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0785214900970459},{"id":"https://openalex.org/C157660682","wikidata":"https://www.wikidata.org/wiki/Q419793","display_name":"Accommodation","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000096985","descriptor_name":"Calponins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000869","descriptor_name":"Anterior Eye Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003239","descriptor_name":"Connective Tissue Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9040467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:176299968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4845869435","display_name":"Eicosanoids and the Outflow Pathways of the Eye","funder_award_id":"R01EY005990","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W71754498","https://openalex.org/W133149325","https://openalex.org/W185086272","https://openalex.org/W1493067897","https://openalex.org/W1505862344","https://openalex.org/W1512795704","https://openalex.org/W1542499527","https://openalex.org/W1582010642","https://openalex.org/W1824224809","https://openalex.org/W1969539915","https://openalex.org/W1988850323","https://openalex.org/W1997364986","https://openalex.org/W2008309107","https://openalex.org/W2018748428","https://openalex.org/W2031128166","https://openalex.org/W2053688453","https://openalex.org/W2057862086","https://openalex.org/W2059589670","https://openalex.org/W2061055950","https://openalex.org/W2064810465","https://openalex.org/W2076406860","https://openalex.org/W2079349853","https://openalex.org/W2080504583","https://openalex.org/W2094364213","https://openalex.org/W2106160398","https://openalex.org/W2119751431","https://openalex.org/W2148059610","https://openalex.org/W2170202796","https://openalex.org/W2230119176","https://openalex.org/W2416965822","https://openalex.org/W2886042269"],"related_works":["https://openalex.org/W2036469922","https://openalex.org/W1969184507","https://openalex.org/W2148476504","https://openalex.org/W2296240596","https://openalex.org/W2148059610","https://openalex.org/W2122818217","https://openalex.org/W1942611570","https://openalex.org/W2342568276","https://openalex.org/W2064793335","https://openalex.org/W348739991"],"abstract_inverted_index":{"PURPOSE:":[0],"Calponins":[1],"are":[2],"a":[3,166,172],"family":[4],"of":[5,28,54,62,82,116,169,175,195,201,270,274],"actin-binding":[6],"proteins":[7,30,70],"known":[8],"to":[9,21,161],"regulate":[10],"aortic":[11],"and":[12,26,36,77,92,118,139,142],"tracheal":[13],"smooth":[14,145,243,247,263],"muscle":[15,47,69,95,182,264],"contraction.":[16],"This":[17,157],"investigation":[18],"was":[19,57,85,121,132,159,205],"undertaken":[20],"assess":[22],"the":[23,105,154,179,192,196,199,253],"presence,":[24],"subtype,":[25],"distribution":[27,53,158],"calponin":[29,55,83,117,130,170,184,202,230,258,271],"in":[31,45,49,59,90,123,134,153,208,216,238,266,272],"human":[32,63,124,223,239],"ciliary":[33,46,68,94,135,181,240,262],"muscle,":[34,136,241,248],"iris,":[35],"other":[37],"anterior":[38,64],"segment":[39,65],"tissues":[40,276],"as":[41,43,249,251],"well":[42,250],"expression":[44,84,89,115],"cells":[48,204,213,265],"vitro.":[50,267],"METHODS:":[51],"The":[52,80,268],"immunoreactivity":[56,131],"assessed":[58,122],"paraffin":[60],"sections":[61],"tissue.":[66],"Human":[67],"were":[71,107,151,214],"analyzed":[72],"by":[73,98,261],"polyacrylamide":[74],"gel":[75],"electrophoresis":[76],"Western":[78,163],"blotting.":[79],"regulation":[81],"compared":[86],"with":[87,109,171],"alpha-sm-actin":[88,119,232],"preconfluent":[91,209],"postconfluent":[93],"cell":[96,103],"cultures":[97,106],"immunocytochemistry.":[99],"To":[100],"determine":[101],"total":[102],"counts,":[104],"counter-stained":[108],"ethidium":[110],"homodimer.":[111],"As":[112],"control":[113],"specimens,":[114],"also":[120,150],"Tenon":[125,224],"fibroblast":[126],"cultures.":[127,221],"RESULTS:":[128],"Strong":[129],"present":[133],"iris":[137,242],"dilator":[138],"sphincter":[140],"muscles,":[141,244],"blood":[143,245],"vessel":[144,246],"muscle.":[146],"Fine":[147],"immunostained":[148],"strands":[149],"observed":[152],"scleral":[155,254],"spur.":[156,255],"similar":[160],"alpha-sm-actin.":[162],"blotting":[164],"showed":[165],"single":[167],"band":[168],"molecular":[173],"weight":[174],"32":[176],"kDa.":[177],"In":[178,256],"cultured":[180],"cells,":[183],"stained":[185,215],"straight":[186],"cable-like":[187],"fibers":[188],"running":[189],"parallel":[190],"along":[191],"long":[193],"axis":[194],"cells.":[197],"Although":[198],"proportion":[200],"immunoreactive":[203],"reduced":[206],"substantially":[207],"cultures,":[210],"virtually":[211],"all":[212],"confluent":[217],"primary":[218],"through":[219],"fourth-passage":[220],"Cultured":[222],"fibroblasts":[225],"did":[226],"not":[227],"show":[228],"either":[229],"or":[231],"immunoreactivity.":[233],"CONCLUSIONS:":[234],"Calponin":[235],"is":[236,259],"expressed":[237,260],"within":[252],"addition,":[257],"role":[269],"contraction":[273],"these":[275],"should":[277],"be":[278],"investigated.":[279]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}