{"id":"https://openalex.org/W176293969","doi":null,"title":"Fate of human keratinocytes during reepithelialization in an organotypic culture model.","display_name":"Fate of human keratinocytes during reepithelialization in an organotypic culture model.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W176293969","mag":"176293969","pmid":"https://pubmed.ncbi.nlm.nih.gov/8015295"},"language":"en","primary_location":{"id":"pmid:8015295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115591926","display_name":"Jonathan A. Garlick","orcid":"https://orcid.org/0009-0008-9500-6435","observed_orcids":["https://orcid.org/0009-0008-9500-6435"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Garlick","raw_affiliation_strings":["Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111710037","display_name":"Lorne B. Taichman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L B Taichman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8238,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.96885636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"70","issue":"6","first_page":"916","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.9829999804496765},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/organotypic-culture","display_name":"organotypic culture","score":0.7940000295639038},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/stratified-squamous-epithelium","display_name":"stratified squamous epithelium","score":0.8429999947547913},{"id":"https://openalex.org/keywords/incisional-wounds","display_name":"incisional wounds","score":0.7369999885559082},{"id":"https://openalex.org/keywords/collagen-matrix","display_name":"collagen matrix","score":0.5600000023841858},{"id":"https://openalex.org/keywords/cell-repopulation","display_name":"cell repopulation","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.719829261302948},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.6476041078567505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5516161918640137},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5318861603736877},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5024716854095459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4705420136451721},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4433360993862152},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41446438431739807},{"id":"https://openalex.org/C28483552","wikidata":"https://www.wikidata.org/wiki/Q3634161","display_name":"Organ culture","level":3,"score":0.4136626720428467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2911953926086426},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2515358328819275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18968933820724487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06683483719825745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05244848132133484}],"mesh":[{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8015295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:176293969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8274986552","display_name":"THE FATE OF ORAL EPITHELIAL STEM CELLS","funder_award_id":"K11DE000263","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2282469193","https://openalex.org/W2016285310","https://openalex.org/W2418255329","https://openalex.org/W2342919730","https://openalex.org/W2807756967","https://openalex.org/W1974256482","https://openalex.org/W1986788704","https://openalex.org/W2477561548","https://openalex.org/W2042169007","https://openalex.org/W3109849579"],"abstract_inverted_index":{"BACKGROUND:":[0],"Reepithelialization":[1,172],"of":[2,33,46,94,139,156,205,211,249,290,299,314],"an":[3,61,85,95,250],"incisional":[4,86],"wound":[5,18,161,170,181,194,224,237,277],"in":[6,65,136,179,192,198,222,303],"a":[7,74,103,164,232,317],"stratified":[8],"squamous":[9],"epithelium":[10,93,182,195],"is":[11,245,307],"accomplished":[12],"by":[13,30,124,163,175],"mobilizing":[14],"keratinocytes":[15,67,158],"from":[16,235],"the":[17,34,131,137,160,169,180,193,209,212,223,236,246,276,297,304],"margins.":[19],"In":[20,37],"vitro":[21],"models":[22],"to":[23,43,81,108],"study":[24,82],"this":[25,265],"phenomenon":[26],"have":[27,54,59,72],"been":[28,41,56],"limited":[29],"incomplete":[31],"differentiation":[32,262],"cultured":[35],"epithelium.":[36],"addition,":[38],"it":[39,306],"has":[40],"difficult":[42],"follow":[44],"fate":[45],"recruited":[47],"keratinocytes,":[48],"since":[49],"techniques":[50],"for":[51,119,130,253],"marking":[52,76],"cells":[53,134,142,191,206,218,229,291,302,315],"not":[55],"available.":[57],"We":[58],"adapted":[60],"organotypic":[62,96,251],"culture":[63,97],"model":[64,98,252],"which":[66,270],"are":[68,283,292],"fully":[69,91],"differentiated":[70,92],"and":[71,106,122,186,203,255,261,319],"utilized":[73],"genetic":[75],"protocol":[77],"with":[78],"retroviral":[79],"vectors":[80],"reepithelialization":[83],"after":[84,113],"wound.":[87],"EXPERIMENTAL":[88],"DESIGN:":[89],"The":[90,147,267],"was":[99,154,173],"incised,":[100],"supported":[101],"on":[102],"collagen":[104],"matrix,":[105],"allowed":[107],"reepithelialize.":[109],"At":[110],"various":[111],"times":[112],"wounding,":[114],"healing":[115],"cultures":[116],"were":[117,196,219],"monitored":[118],"migration,":[120,259],"differentiation,":[121],"proliferation":[123,202],"immunohistochemical":[125],"staining.":[126],"Histochemical":[127],"staining":[128],"specific":[129],"genetically":[132,216,300],"marked":[133,190,217,301],"assisted":[135],"determination":[138],"how":[140],"these":[141,281],"behaved":[143],"during":[144,184,264],"reepithelialization.":[145],"RESULTS:":[146],"first":[148,247],"event":[149],"observed":[150],"(at":[151],"8":[152],"hours)":[153],"migration":[155,274],"suprabasal":[157],"into":[159],"followed":[162],"transient":[165],"proliferative":[166,268],"burst":[167],"at":[168,275,310],"margin.":[171],"complete":[174],"24":[176],"hours.":[177],"Proliferation":[178],"persisted":[183],"stratification":[185],"terminal":[187],"differentiation.":[188],"Genetically":[189],"present":[197],"clusters":[199],"demonstrating":[200],"that":[201,227,258,280,309],"displacement":[204],"occurred":[207],"near":[208],"edge":[210,238],"epithelial":[213],"tongue.":[214],"Individual":[215],"also":[220],"found":[221],"epithelium,":[225],"indicating":[226],"individual":[228],"had":[230],"migrated":[231],"considerable":[233],"distance":[234],"without":[239],"having":[240],"undergone":[241],"replication.":[242],"CONCLUSIONS:":[243],"This":[244],"report":[248],"reepithelialization,":[254],"we":[256],"demonstrate":[257],"proliferation,":[260],"occur":[263],"process.":[266],"response":[269],"follows":[271],"initial":[272],"cell":[273],"margins":[278],"suggests":[279],"events":[282],"temporally":[284],"coordinated":[285],"as":[286],"phenotypically":[287],"different":[288],"populations":[289],"sequentially":[293],"activated.":[294],"By":[295],"following":[296],"distribution":[298],"wound,":[305],"evident":[308],"least":[311],"two":[312],"types":[313],"repopulate":[316],"wound-proliferative":[318],"migratory":[320],"cells.":[321]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
