{"id":"https://openalex.org/W1762575174","doi":"https://doi.org/10.4049/jimmunol.182.1.477","title":"Human Cytomegalovirus Paralyzes Macrophage Motility through Down-Regulation of Chemokine Receptors, Reorganization of the Cytoskeleton, and Release of Macrophage Migration Inhibitory Factor","display_name":"Human Cytomegalovirus Paralyzes Macrophage Motility through Down-Regulation of Chemokine Receptors, Reorganization of the Cytoskeleton, and Release of Macrophage Migration Inhibitory Factor","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1762575174","doi":"https://doi.org/10.4049/jimmunol.182.1.477","mag":"1762575174","pmid":"https://pubmed.ncbi.nlm.nih.gov/19109179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3618717"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.1.477","doi":"https://doi.org/10.4049/jimmunol.182.1.477","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.1.477","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3618717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029006093","display_name":"Giada Frascaroli","orcid":"https://orcid.org/0000-0001-8186-7594","observed_orcids":["https://orcid.org/0000-0001-8186-7594"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Giada Frascaroli","raw_affiliation_strings":["Institute for Virology, University of Ulm , Ulm,","*Institute for Virology, University of Ulm, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, University of Ulm , Ulm,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"*Institute for Virology, University of Ulm, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085005003","display_name":"Stefania Varani","orcid":"https://orcid.org/0000-0003-0862-4937","observed_orcids":["https://orcid.org/0000-0003-0862-4937"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Varani","raw_affiliation_strings":["Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna , Bologna,","\u2020Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna, Bologna, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna , Bologna,","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"\u2020Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna, Bologna, Italy;","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000565932","display_name":"Nina Blankenhorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nina Blankenhorn","raw_affiliation_strings":["Institute for Virology, University of Ulm , Ulm,","*Institute for Virology, University of Ulm, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, University of Ulm , Ulm,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"*Institute for Virology, University of Ulm, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005872310","display_name":"Robert Pretsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Robert Pretsch","raw_affiliation_strings":["Institute for Virology, University of Ulm , Ulm,","*Institute for Virology, University of Ulm, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, University of Ulm , Ulm,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"*Institute for Virology, University of Ulm, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068605002","display_name":"Michael Bacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Bacher","raw_affiliation_strings":["Department of Neurology, Philipps-University of Marburg , Marburg,","\u2021Department of Neurology, Philipps-University of Marburg, Marburg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Philipps-University of Marburg , Marburg,","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"\u2021Department of Neurology, Philipps-University of Marburg, Marburg, Germany; and","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008065494","display_name":"Lin Leng","orcid":"https://orcid.org/0000-0002-0605-358X","observed_orcids":["https://orcid.org/0000-0002-0605-358X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Leng","raw_affiliation_strings":["Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020928977","display_name":"Richard Bucala","orcid":"https://orcid.org/0000-0001-5783-5736","observed_orcids":["https://orcid.org/0000-0001-5783-5736"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Bucala","raw_affiliation_strings":["Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004764897","display_name":"Maria Paola Landini","orcid":"https://orcid.org/0000-0002-2842-9824","observed_orcids":["https://orcid.org/0000-0002-2842-9824","https://orcid.org/0000-0003-2031-4990"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Paola Landini","raw_affiliation_strings":["Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna , Bologna,","\u2020Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna, Bologna, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna , Bologna,","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"\u2020Department of Hematology and Oncology \u201cL. and A. Seragnoli\u201d, University of Bologna, Bologna, Italy;","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017305312","display_name":"Thomas Mertens","orcid":"https://orcid.org/0000-0002-4944-3182","observed_orcids":["https://orcid.org/0000-0002-4944-3182"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Mertens","raw_affiliation_strings":["Institute for Virology, University of Ulm , Ulm,","*Institute for Virology, University of Ulm, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, University of Ulm , Ulm,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"*Institute for Virology, University of Ulm, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000565932","https://openalex.org/A5005872310","https://openalex.org/A5017305312","https://openalex.org/A5029006093"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.0435,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96544282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"182","issue":"1","first_page":"477","last_page":"488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/macrophage-migration","display_name":"macrophage migration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.847000002861023},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cytoskeletal-rearrangement","display_name":"cytoskeletal rearrangement","score":0.9559999704360962},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.7760000228881836},{"id":"https://openalex.org/keywords/actin-fibers","display_name":"actin fibers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.925000011920929},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.7866434454917908},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.728300929069519},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6873617768287659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6381345987319946},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.62917560338974},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5838800668716431},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5814722776412964},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5445589423179626},{"id":"https://openalex.org/C170217031","wikidata":"https://www.wikidata.org/wiki/Q6725509","display_name":"Macrophage inflammatory protein","level":4,"score":0.5283646583557129},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5077141523361206},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5051818490028381},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.47970765829086304},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4789981544017792},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.4596526026725769},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4568932056427002},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.41266167163848877},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3710930347442627},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.369565486907959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3689948320388794},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.20178988575935364},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1622292697429657},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15204688906669617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.4049/jimmunol.182.1.477","doi":"https://doi.org/10.4049/jimmunol.182.1.477","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.1.477","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19109179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19109179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2620235","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3618717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3618717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3618717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},{"id":"pmh:oai:cris.unibo.it:11585/69655","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/69655","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2620235","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3618717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2521185677","display_name":"Innate and Adaptive Immune Mechanisms in Arthritis","funder_award_id":"R01AR050498","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W145218246","https://openalex.org/W1522317349","https://openalex.org/W1587324932","https://openalex.org/W1600542667","https://openalex.org/W1810970846","https://openalex.org/W1895115148","https://openalex.org/W1963962908","https://openalex.org/W1964136591","https://openalex.org/W1972769387","https://openalex.org/W1979244891","https://openalex.org/W1986837253","https://openalex.org/W1988250064","https://openalex.org/W1988332936","https://openalex.org/W1991922050","https://openalex.org/W1992726653","https://openalex.org/W1996688582","https://openalex.org/W1999028128","https://openalex.org/W1999620041","https://openalex.org/W1999730899","https://openalex.org/W2013659792","https://openalex.org/W2016738466","https://openalex.org/W2018490006","https://openalex.org/W2023926137","https://openalex.org/W2029174607","https://openalex.org/W2031138211","https://openalex.org/W2035993484","https://openalex.org/W2038341013","https://openalex.org/W2039156817","https://openalex.org/W2041791156","https://openalex.org/W2049955481","https://openalex.org/W2051391805","https://openalex.org/W2062834849","https://openalex.org/W2063220206","https://openalex.org/W2064914874","https://openalex.org/W2067458000","https://openalex.org/W2067937110","https://openalex.org/W2068669952","https://openalex.org/W2078141647","https://openalex.org/W2083825092","https://openalex.org/W2086757300","https://openalex.org/W2090056328","https://openalex.org/W2091478221","https://openalex.org/W2092520245","https://openalex.org/W2093705034","https://openalex.org/W2093833484","https://openalex.org/W2094547642","https://openalex.org/W2094644744","https://openalex.org/W2096179876","https://openalex.org/W2098217581","https://openalex.org/W2114639316","https://openalex.org/W2114972655","https://openalex.org/W2117479659","https://openalex.org/W2119386841","https://openalex.org/W2124496722","https://openalex.org/W2143740263","https://openalex.org/W2145687844","https://openalex.org/W2151751706","https://openalex.org/W2154776647","https://openalex.org/W2155932820","https://openalex.org/W2168177577","https://openalex.org/W2170738140","https://openalex.org/W2170770186"],"related_works":["https://openalex.org/W2143740263","https://openalex.org/W2038341013","https://openalex.org/W2018490006","https://openalex.org/W2168345783","https://openalex.org/W2399663635","https://openalex.org/W2900214401","https://openalex.org/W2135065794","https://openalex.org/W1873909974","https://openalex.org/W3193507637","https://openalex.org/W1980003689"],"abstract_inverted_index":{"Macrophages":[0],"contribute":[1],"to":[2,6,28,88,92,158,210,220,227],"host":[3,31],"defense":[4],"and":[5,85,94,99,105,135,155,214,226],"the":[7,30,49,121,127,132,138,160,171,182,197,231],"maintenance":[8],"of":[9,17,63,69,120,126,131,137,149,162,168,188,193,199,216,223,230],"immune":[10,32,45],"homeostasis.":[11],"Conversely,":[12],"they":[13],"are":[14],"important":[15],"targets":[16],"human":[18,72],"cytomegalovirus":[19],"(HCMV),":[20],"a":[21,117,185],"herpesvirus":[22],"that":[23,205],"has":[24],"evolved":[25],"many":[26],"strategies":[27],"modulate":[29],"response.":[33],"Because":[34,166],"an":[35,43,191,221,228],"efficient":[36],"macrophage":[37,56,150,194],"trafficking":[38],"is":[39],"required":[40],"for":[41,181],"triggering":[42],"adequate":[44],"response,":[46],"we":[47,65,178],"investigated":[48],"effects":[50],"exerted":[51],"by":[52,124],"HCMV":[53,115,200,206],"infection":[54],"on":[55],"migratory":[57],"properties.":[58],"By":[59],"using":[60],"endotheliotropic":[61],"strains":[62],"HCMV,":[64],"obtained":[66],"high":[67,147],"rates":[68],"productively":[70],"infected":[71,144],"monocyte-derived":[73],"macrophages":[74],"(MDM).":[75],"Twenty-four":[76],"hours":[77],"after":[78],"infection,":[79],"MDM":[80,145,176],"showed":[81],"reduced":[82],"polar":[83],"morphology":[84],"became":[86],"unable":[87],"migrate":[89],"in":[90,196],"response":[91],"inflammatory":[93],"lymphoid":[95],"chemokines,":[96],"bacterial":[97],"products":[98],"growth":[100],"factors,":[101],"despite":[102],"being":[103],"viable":[104],"metabolically":[106],"active.":[107],"Although":[108],"chemotactic":[109],"receptors":[110],"were":[111,156],"only":[112],"partially":[113],"affected,":[114],"induced":[116],"dramatic":[118],"reorganization":[119],"cytoskeleton":[122],"characterized":[123],"rupture":[125],"microtubular":[128],"network,":[129],"stiffness":[130],"actin":[133],"fibers,":[134],"collapse":[136],"podosomes.":[139],"Furthermore,":[140],"supernatants":[141],"harvested":[142],"from":[143,170],"contained":[146],"amounts":[148],"migration":[151,161,195],"inhibitory":[152],"factor":[153],"(MIF)":[154],"capable":[157],"block":[159],"neighboring":[163],"uninfected":[164],"MDM.":[165],"immunodepletion":[167],"MIF":[169,189],"conditioned":[172],"medium":[173],"completely":[174],"restored":[175],"chemotaxis,":[177],"could":[179],"show":[180],"first":[183],"time":[184],"functional":[186],"role":[187],"as":[190],"inhibitor":[192],"context":[198],"infection.":[201],"Our":[202],"findings":[203],"reveal":[204],"uses":[207],"different":[208],"mechanisms":[209],"interfere":[211],"with":[212],"movement":[213],"positioning":[215],"macrophages,":[217],"possibly":[218],"leading":[219],"impairment":[222],"antiviral":[224],"responses":[225],"enhancement":[229],"local":[232],"inflammation.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}