{"id":"https://openalex.org/W1762002010","doi":"https://doi.org/10.1158/1538-7445.am2014-3446","title":"Abstract 3446: Fibroblast growth factor 23 promotes prostate cancer cell proliferation and invasiveness in vitro","display_name":"Abstract 3446: Fibroblast growth factor 23 promotes prostate cancer cell proliferation and invasiveness in vitro","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1762002010","doi":"https://doi.org/10.1158/1538-7445.am2014-3446","mag":"1762002010"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-3446","doi":"https://doi.org/10.1158/1538-7445.am2014-3446","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3446","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100452846","display_name":"Shu Feng","orcid":"https://orcid.org/0000-0002-5372-4497","observed_orcids":["https://orcid.org/0000-0002-5372-4497"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Feng","raw_affiliation_strings":["Baylor College Of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College Of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ittmann","raw_affiliation_strings":["Baylor College Of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College Of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"3446","last_page":"3446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.2328999936580658,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.07720000296831131,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9430000185966492},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/klotho","display_name":"Klotho","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8740000128746033},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.7239999771118164},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.675000011920929},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.8980000019073486},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.793828010559082},{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.6961233615875244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6208535432815552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5911238193511963},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.5198681354522705},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.5005576610565186},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.49534884095191956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4953228533267975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4668377637863159},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4560442566871643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44815126061439514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34567904472351074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1503678262233734},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.09779521822929382},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-3446","doi":"https://doi.org/10.1158/1538-7445.am2014-3446","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3446","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1527661581","https://openalex.org/W2511226692","https://openalex.org/W2102174623","https://openalex.org/W7097579174","https://openalex.org/W2331806507","https://openalex.org/W2324766056","https://openalex.org/W2106054588","https://openalex.org/W2741975417","https://openalex.org/W2914574502","https://openalex.org/W3013816842"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1],"cancer":[2,19,34,142,148,175,192,204,247,261,293,352,362,378],"is":[3,23,62,154,243,256],"the":[4,13,29,47,68,83,86,169,180,185,200,389,394],"most":[5],"common":[6],"malignancy":[7],"among":[8],"American":[9,395],"men":[10],"and":[11,59,74,97,211,224,308,311,316,332,340,354,364,381],"remains":[12],"second":[14],"leading":[15],"cause":[16],"of":[17,28,67,85,103,133,160,168,171,187,320,388,393],"male":[18],"mortality.":[20],"Since":[21],"age":[22],"thought":[24],"to":[25,122,164,249],"be":[26],"one":[27],"crucial":[30],"factors":[31],"in":[32,56,82,94,137,173,199,230,245,259,262,342,383],"prostate":[33,57,174,191,203,215,246,251,260,276,292,351,361,377],"development,":[35],"fibroblast":[36],"growth":[37,302,363,373],"factor":[38,374],"23":[39,375],"(FGF23),":[40],"which":[41,76],"forms":[42],"a":[43,53,63,91],"complex":[44],"with":[45,139,144,146,156,264],"Klotho,":[46],"age-related":[48],"gene":[49,195,241],"product,":[50],"could":[51,108,359],"play":[52],"key":[54],"role":[55,93,170],"development":[58],"progression.":[60,193],"FGF23":[61,188,194,223,240,253,290,321,324,348,356],"peptide":[64],"hormone":[65],"member":[66],"endocrine":[69],"FGF":[70,79],"subfamily":[71],"(FGF19,":[72],"FGF21,":[73],"FGF23),":[75],"signals":[77],"through":[78],"receptors":[80],"(FGFRs)":[81],"presence":[84],"coreceptor":[87],"\u03b1-Klotho.":[88],"FGF-23":[89,107,134,153,172],"has":[90,127],"critical":[92],"phosphate":[95],"homeostasis":[96],"vitamin":[98,116],"D":[99,105,117],"metabolism.":[100],"The":[101],"regulation":[102],"1,25-Dihydroxyvitamin":[104],"by":[106,297,314,323],"also":[109],"have":[110,119,123,176],"implications":[111],"for":[112,305,397],"cancers,":[113],"given":[114],"that":[115,130,221,239,288,347],"metabolites":[118],"been":[120,128,177],"shown":[121],"anticarcinogenic":[124],"effects.":[125],"It":[126],"reported":[129],"higher":[131,258],"concentrations":[132],"were":[135],"found":[136],"patients":[138],"advanced":[140],"ovarian":[141],"compared":[143,248],"those":[145],"early-stage":[147],"or":[149],"control":[150],"subjects;":[151],"circulating":[152],"associated":[155],"an":[157,212],"increased":[158],"risk":[159],"colorectal":[161],"adenoma;":[162],"however,":[163],"date,":[165],"no":[166],"investigations":[167],"reported.":[178],"In":[179],"present":[181],"study":[182],"we":[183],"investigated":[184],"function":[186,285],"on":[189],"human":[190,350],"expression":[196,242,254,322],"was":[197],"determined":[198],"commonly":[201],"used":[202],"cell":[205,216,233,294,334,379],"lines:":[206],"PC3,":[207],"LNCaP,":[208],"DU145,":[209],"VCaP,":[210],"immortalized":[213],"normal":[214,250,265,275],"line":[217],"PNTIA.":[218],"RT-PCR":[219,237],"showed":[220],"both":[222,306],"\u03b1Klotho":[225],"(KLA)":[226],"genes":[227],"are":[228],"expressed":[229],"all":[231],"these":[232],"lines.":[234],"Quantitative":[235],"real-time":[236],"indicated":[238],"elevated":[244],"tissue;":[252],"frequency":[255],"significantly":[257,329],"compare":[263],"tissue":[266],"(prostate":[267],"cancer:":[268],"total":[269,278],"case":[270],"number":[271,279],"35,":[272],"positive":[273,281],"23;":[274],"tissue:":[277],"33,":[280],"15;":[282],"p=0.04841).":[283],"Biological":[284],"assays":[286],"demonstrated":[287],"exogenous":[289],"stimulates":[291],"proliferation":[295,380],"(LNCaP":[296,313],"30%,":[298],"PC3":[299,309,317,331],"20%),":[300],"anchorage-independent":[301],"(by":[303],"60%":[304],"LNCaP":[307,333],"cells),":[310],"invasion":[312],"50%":[315],"55%).":[318],"Suppression":[319],"short":[325],"hairpin":[326],"RNA":[327],"(shRNA)":[328],"inhibits":[330],"proliferation,":[335],"soft":[336],"agar":[337],"colony":[338],"formation,":[339],"invasiveness":[341,382],"vitro.":[343,384],"These":[344],"data":[345],"suggest":[346],"promotes":[349,376],"progression":[353],"targeting":[355],"signaling":[357],"pathway":[358],"decrease":[360],"metastasis.":[365],"Citation":[366],"Format:":[367],"Shu":[368],"Feng,":[369],"Michael":[370],"Ittmann.":[371],"Fibroblast":[372],"[abstract].":[385],"In:":[386],"Proceedings":[387],"105th":[390],"Annual":[391],"Meeting":[392],"Association":[396],"Cancer":[398,409],"Research;":[399],"2014":[400],"Apr":[401],"5-9;":[402],"San":[403],"Diego,":[404],"CA.":[405],"Philadelphia":[406],"(PA):":[407],"AACR;":[408],"Res":[410],"2014;74(19":[411],"Suppl):Abstract":[412],"nr":[413],"3446.":[414],"doi:10.1158/1538-7445.AM2014-3446":[415]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}