{"id":"https://openalex.org/W1761848048","doi":"https://doi.org/10.1007/s10456-015-9485-2","title":"The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence","display_name":"The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence","publication_year":2015,"publication_date":"2015-09-28","ids":{"openalex":"https://openalex.org/W1761848048","doi":"https://doi.org/10.1007/s10456-015-9485-2","mag":"1761848048","pmid":"https://pubmed.ncbi.nlm.nih.gov/26416763","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4700080"},"language":"en","primary_location":{"id":"doi:10.1007/s10456-015-9485-2","doi":"https://doi.org/10.1007/s10456-015-9485-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-015-9485-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-015-9485-2.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10456-015-9485-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102861985","display_name":"Monika Maleszewska","orcid":"https://orcid.org/0000-0002-2951-9186","observed_orcids":["https://orcid.org/0000-0002-2951-9186"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4210153965","display_name":"Max Planck Institute for Biology of Ageing","ror":"https://ror.org/04xx1tc24","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210153965"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Monika Maleszewska","raw_affiliation_strings":["Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands. m.maleszewska@gmail.com","Max Planck Research Group Chromatin and Ageing, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931, Cologne, Germany. m.maleszewska@gmail.com","Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","Max Planck Research Group Chromatin and Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands. m.maleszewska@gmail.com","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Max Planck Research Group Chromatin and Ageing, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931, Cologne, Germany. m.maleszewska@gmail.com","institution_ids":["https://openalex.org/I4210153965"]},{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Max Planck Research Group Chromatin and Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany","institution_ids":["https://openalex.org/I4210153965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016349498","display_name":"Byambasuren Vanchin","orcid":"https://orcid.org/0000-0002-4283-253X","observed_orcids":["https://orcid.org/0000-0002-4283-253X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Byambasuren Vanchin","raw_affiliation_strings":["Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands","Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031487758","display_name":"Martin C. Harmsen","orcid":"https://orcid.org/0000-0002-7128-2741","observed_orcids":["https://orcid.org/0000-0002-7128-2741"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin C. Harmsen","raw_affiliation_strings":["Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands","Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030899657","display_name":"Guido Krenning","orcid":"https://orcid.org/0000-0001-5850-5667","observed_orcids":["https://orcid.org/0000-0001-5850-5667"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Guido Krenning","raw_affiliation_strings":["Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands. g.krenning@umcg.nl","Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713 GZ, Groningen, The Netherlands. g.krenning@umcg.nl","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Cardiovascular Regenerative Medicine Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030899657","https://openalex.org/A5102861985"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384","https://openalex.org/I4210153965"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":1.9058,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.86147128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"9","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/endothelial-quiescence","display_name":"endothelial quiescence","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.8930000066757202},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atheroprotection","display_name":"atheroprotection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/endothelial-transcriptome","display_name":"endothelial transcriptome","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.7376034259796143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7106133699417114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5818437933921814},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5555941462516785},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5239663124084473},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4912211298942566},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.48941269516944885},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.45835840702056885},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4521300494670868},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4369892179965973},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43199437856674194},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3403359651565552},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3378404974937439},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27895063161849976},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.22609588503837585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21738508343696594},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048054","descriptor_name":"Mitogen-Activated Protein Kinase 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1007/s10456-015-9485-2","doi":"https://doi.org/10.1007/s10456-015-9485-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-015-9485-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-015-9485-2.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3682561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4700080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26416763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26416763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4700080","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4700080/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire/e348ec7d-283d-4b07-ac2b-79c497c61ede","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/files/37954773/art_3A10.1007_2Fs10456_015_9485_2.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Maleszewska, M, Vanchin, B, Harmsen, M C & Krenning, G 2016, 'The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence', Angiogenesis, vol. 19, no. 1, pp. 9-24. https://doi.org/10.1007/s10456-015-9485-2","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/e348ec7d-283d-4b07-ac2b-79c497c61ede","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e348ec7d-283d-4b07-ac2b-79c497c61ede","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Angiogenesis, 19(1), 9 - 24. SPRINGER","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s10456-015-9485-2","doi":"https://doi.org/10.1007/s10456-015-9485-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-015-9485-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-015-9485-2.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3828055511","display_name":null,"funder_award_id":"916.11.022","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6409822908","display_name":null,"funder_award_id":"40-00506-98-9021","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1761848048.pdf","grobid_xml":"https://content.openalex.org/works/W1761848048.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1583240815","https://openalex.org/W1797828706","https://openalex.org/W1917706778","https://openalex.org/W1960838472","https://openalex.org/W1963769227","https://openalex.org/W1965917470","https://openalex.org/W1969353942","https://openalex.org/W1969382272","https://openalex.org/W1969929083","https://openalex.org/W1978041309","https://openalex.org/W1978667789","https://openalex.org/W1981348175","https://openalex.org/W1987061826","https://openalex.org/W1987742709","https://openalex.org/W1993541144","https://openalex.org/W1997309935","https://openalex.org/W2000331534","https://openalex.org/W2020541351","https://openalex.org/W2024187290","https://openalex.org/W2024685913","https://openalex.org/W2025121278","https://openalex.org/W2027239626","https://openalex.org/W2029807820","https://openalex.org/W2033562493","https://openalex.org/W2039269113","https://openalex.org/W2052090609","https://openalex.org/W2057865864","https://openalex.org/W2058727418","https://openalex.org/W2066233510","https://openalex.org/W2068440074","https://openalex.org/W2070050178","https://openalex.org/W2072466432","https://openalex.org/W2094472651","https://openalex.org/W2096469282","https://openalex.org/W2099959716","https://openalex.org/W2100305481","https://openalex.org/W2101139969","https://openalex.org/W2102987835","https://openalex.org/W2103017472","https://openalex.org/W2105924489","https://openalex.org/W2111076607","https://openalex.org/W2111132814","https://openalex.org/W2113613985","https://openalex.org/W2115533377","https://openalex.org/W2122914905","https://openalex.org/W2126725396","https://openalex.org/W2127517570","https://openalex.org/W2128177783","https://openalex.org/W2129482433","https://openalex.org/W2133546870","https://openalex.org/W2136482257","https://openalex.org/W2136570275","https://openalex.org/W2136918601","https://openalex.org/W2140146894","https://openalex.org/W2145913988","https://openalex.org/W2147107152","https://openalex.org/W2150182400","https://openalex.org/W2152389213","https://openalex.org/W2156564520","https://openalex.org/W2158417865","https://openalex.org/W2161645441","https://openalex.org/W2334316609","https://openalex.org/W2507585622","https://openalex.org/W4210767115","https://openalex.org/W7074230359"],"related_works":["https://openalex.org/W2488485424","https://openalex.org/W2803392071","https://openalex.org/W2931401907","https://openalex.org/W2884409188","https://openalex.org/W2981804490","https://openalex.org/W4410415643","https://openalex.org/W2912031349","https://openalex.org/W1981645119","https://openalex.org/W7128308480","https://openalex.org/W2151208929"],"abstract_inverted_index":{"High":[0],"uniform":[1],"fluid":[2],"shear":[3],"stress":[4],"(FSS)":[5],"is":[6,37,53,213,254],"atheroprotective":[7,225],"and":[8,13,39,127,142,203],"preserves":[9],"the":[10,34,42,56,69,72,87,93,98,107,113,116,155,164,183,221,224,234,237,240,248,258],"endothelial":[11,62,103,122,170,186],"phenotype":[12],"function":[14],"through":[15],"activation":[16,78,222],"of":[17,58,71,79,89,95,109,115,119,136,154,166,185,223,239,242,261],"downstream":[18],"mediators":[19],"such":[20],"as":[21,197],"MAPK7":[22,81,100,226],"(Erk5).":[23],"Endothelial":[24],"cells":[25,187,249],"respond":[26],"to":[27,30,250],"FSS":[28,59,67,232,262],"thanks":[29],"mechanotransduction.":[31],"However,":[32],"how":[33],"resulting":[35],"signaling":[36,101],"integrated":[38],"resolved":[40],"at":[41],"epigenetic":[43],"level":[44],"remains":[45],"elusive.":[46],"We":[47,64,132],"hypothesized":[48],"that":[49,66,211],"Polycomb":[50,73],"methyltransferase":[51,74],"EZH2":[52,96,120,141,167,202,212,218,230,253],"involved":[54],"in":[55,60,102,106,161,179,229,236,263],"effects":[57,260],"human":[61],"cells.":[63],"showed":[65],"decreases":[68],"expression":[70,118,130,181,238],"EZH2.":[75,90],"Despite":[76],"simultaneous":[77],"MAPK7,":[80],"pathway":[82],"does":[83],"not":[84],"directly":[85],"influence":[86,114],"transcription":[88],"Interestingly":[91],"though,":[92],"knockdown":[94],"activates":[97],"protective":[99,259],"cells,":[104],"even":[105],"absence":[108],"FSS.":[110,143],"To":[111],"understand":[112],"FSS-decreased":[117],"on":[121,139],"transcriptome,":[123],"we":[124],"performed":[125],"RNA-seq":[126],"differential":[128],"gene":[129,206],"analysis.":[131],"identified":[133],"candidate":[134],"groups":[135],"genes":[137],"dependent":[138],"both":[140],"Among":[144],"those,":[145],"Gene":[146],"Ontology":[147],"overrepresentation":[148],"analysis":[149,194],"revealed":[150],"highly":[151],"significant":[152],"enrichment":[153],"cell":[156,173,204,243],"cycle-related":[157,205,244],"genes,":[158,245],"suggesting":[159],"changes":[160],"proliferation.":[162],"Indeed,":[163],"depletion":[165],"strongly":[168],"inhibited":[169],"proliferation,":[171],"indicating":[172],"cycle":[174],"arrest.":[175],"The":[176],"concomitant":[177],"decrease":[178,235],"CCNA":[180],"suggests":[182],"transition":[184],"into":[188],"a":[189,198,214],"quiescent":[190],"phenotype.":[191],"Further":[192],"bioinformatical":[193],"suggested":[195],"TXNIP":[196],"possible":[199],"mediator":[200],"between":[201],"network.":[207],"Our":[208],"data":[209],"show":[210],"FSS-responsive":[215],"gene.":[216],"Decreased":[217],"levels":[219],"enhance":[220],"signaling.":[227],"Decrease":[228],"under":[231],"mediates":[233],"network":[241],"which":[246],"allows":[247],"enter":[251],"quiescence.":[252],"therefore":[255],"important":[256],"for":[257],"endothelium.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
