{"id":"https://openalex.org/W176163184","doi":null,"title":"Modification of delayed-type hypersensitivity reactions to ovalbumin in cyclosporin A-treated guinea-pigs.","display_name":"Modification of delayed-type hypersensitivity reactions to ovalbumin in cyclosporin A-treated guinea-pigs.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W176163184","mag":"176163184","pmid":"https://pubmed.ncbi.nlm.nih.gov/6822404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453910"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453910","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Thomson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000980616","display_name":"D K Moon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Moon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017332423","display_name":"Yasuhiro Inoue","orcid":"https://orcid.org/0000-0002-5266-7603","observed_orcids":["https://orcid.org/0000-0002-5266-7603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024247143","display_name":"Carolyn L. Geczy","orcid":"https://orcid.org/0000-0001-9104-2246","observed_orcids":["https://orcid.org/0000-0001-9104-2246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Geczy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072959814","display_name":"DAVID S. NELSON","orcid":"https://orcid.org/0009-0008-5993-8710","observed_orcids":["https://orcid.org/0009-0008-5993-8710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2137,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.92641587,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"48","issue":"2","first_page":"301","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.2151000052690506,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lymphocyte-transformation","display_name":"lymphocyte transformation","score":0.75},{"id":"https://openalex.org/keywords/macrophage-migration-inhibition","display_name":"macrophage migration inhibition","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lymphokines","display_name":"lymphokines","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/suppressor-cells","display_name":"suppressor cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/arthus-reaction","display_name":"Arthus reaction","score":0.753000020980835},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7555770874023438},{"id":"https://openalex.org/C3017924640","wikidata":"https://www.wikidata.org/wiki/Q7860879","display_name":"Delayed hypersensitivity","level":3,"score":0.7026464343070984},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.643120288848877},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6052293181419373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5915549993515015},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5507411360740662},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5057566165924072},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.48348289728164673},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4320825934410095},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4273691773414612},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41300636529922485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3325394093990326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2974504232406616},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2915019989013672},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27177420258522034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05969563126564026},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1453910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:6822404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6822404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:176163184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6822404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W77372708","https://openalex.org/W121524232","https://openalex.org/W159354068","https://openalex.org/W1513402792","https://openalex.org/W1530475382","https://openalex.org/W1583522809","https://openalex.org/W1604963391","https://openalex.org/W1653603848","https://openalex.org/W1921599390","https://openalex.org/W1970833240","https://openalex.org/W1977790681","https://openalex.org/W1993014540","https://openalex.org/W2025748559","https://openalex.org/W2031247839","https://openalex.org/W2050492409","https://openalex.org/W2075196328","https://openalex.org/W2075580432","https://openalex.org/W2080064179","https://openalex.org/W2083657978","https://openalex.org/W2083998637","https://openalex.org/W2109082419","https://openalex.org/W2141495155","https://openalex.org/W2146643981","https://openalex.org/W2395647253","https://openalex.org/W2413757649","https://openalex.org/W2422147606","https://openalex.org/W2439819838","https://openalex.org/W2475335850"],"related_works":["https://openalex.org/W1995235371","https://openalex.org/W2396703249","https://openalex.org/W2017216502","https://openalex.org/W2419077873","https://openalex.org/W2071354990","https://openalex.org/W203637327","https://openalex.org/W2069814622","https://openalex.org/W1966552787","https://openalex.org/W2086068555","https://openalex.org/W1966978544"],"abstract_inverted_index":{"Cyclosporin":[0],"A":[1,43,65,74,116,148,174,207],"(Cs":[2,73],"A)":[3],"administered":[4],"daily":[5],"(25":[6],"mg/kg":[7],"per":[8],"os)":[9],"to":[10,130,153,166,183],"outbred":[11],"guinea-pigs":[12,170],"for":[13,46],"2":[14],"weeks":[15],"following":[16,70],"immunization":[17,72],"with":[18,172,211],"ovalbumin":[19],"(OVA;":[20],"CsA":[21],"0-13)":[22],"caused":[23,76,118],"profound":[24],"suppression":[25,121],"of":[26,36,79,90,107,122,126,139,214,217],"14-day":[27,80],"delayed-type":[28],"hypersensitivity":[29],"(DTH)":[30],"skin":[31,53,81],"reactions.":[32],"Very":[33],"marked":[34],"impairment":[35],"DTH":[37,91,181,222],"was":[38,44],"also":[39],"found":[40],"when":[41],"Cs":[42,64,115,147,173,206],"given":[45,66],"the":[47,86,105,123,140,212,225],"first":[48],"time":[49],"24":[50,59],"hr":[51,60],"before":[52],"testing":[54],"and":[55,58,88,103,111,132,137,197],"at":[56],"6":[57],"thereafter.":[61],"In":[62],"contrast,":[63],"on":[67],"days":[68],"0-4":[69],"OVA":[71],"0-4)":[75],"dose-related":[77],"potentiation":[78],"responses.":[82],"These":[83],"changes":[84],"in":[85,92,99,104,164,188,224],"magnitude":[87],"character":[89],"vivo":[93],"were":[94],"accompanied":[95],"by":[96],"striking":[97],"alterations":[98],"lymphocyte":[100,159],"transformation":[101,160],"responses":[102,125,152,182],"extent":[106],"macrophage":[108,143],"migration":[109,135],"inhibition":[110,136],"lymphokine":[112,141,162],"production.":[113],"Whereas":[114],"(0-13)":[117],"almost":[119],"total":[120],"mitogenic":[124],"lymph":[127],"node":[128],"cells":[129,219],"PHA":[131],"antigen,":[133],"OVA-induced":[134],"production":[138,163],"inducing":[142],"procoagulant":[144],"activity":[145],"(MPCA),":[146],"(0-4)":[149,175,208],"augmented":[150,180],"these":[151,204],"OVA,":[154],"but":[155,179],"did":[156],"not":[157],"affect":[158],"or":[161],"response":[165],"mitogen.":[167],"Strain":[168],"13":[169],"treated":[171],"showed":[176],"depressed":[177],"Arthus,":[178],"OVA.":[184],"This":[185],"significant":[186],"increase":[187],"cell-mediated":[189],"immunity":[190],"could":[191],"be":[192],"passively":[193],"transferred":[194],"using":[195],"spleen":[196],"peritoneal":[198],"exudate":[199],"cells,":[200],"suggesting":[201],"that":[202],"under":[203],"circumstances":[205],"may":[209],"interfere":[210],"generation":[213],"a":[215],"population":[216],"suppressor":[218],"which":[220],"regulate":[221],"reactions":[223],"guinea-pig.":[226]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
