{"id":"https://openalex.org/W176161682","doi":"https://doi.org/10.1016/s0021-9258(19)43576-x","title":"The Interaction of the Lanthanide Ions with Staphylococcal Nuclease","display_name":"The Interaction of the Lanthanide Ions with Staphylococcal Nuclease","publication_year":1973,"publication_date":"1973-08-01","ids":{"openalex":"https://openalex.org/W176161682","doi":"https://doi.org/10.1016/s0021-9258(19)43576-x","mag":"176161682","pmid":"https://pubmed.ncbi.nlm.nih.gov/4723899"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)43576-x","doi":"https://doi.org/10.1016/s0021-9258(19)43576-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43576-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)43576-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066321804","display_name":"Bruce Furie","orcid":"https://orcid.org/0000-0001-7610-1076","observed_orcids":["https://orcid.org/0000-0001-7610-1076"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Furie","raw_affiliation_strings":["From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109042965","display_name":"Ann Eastlake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Eastlake","raw_affiliation_strings":["From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048178","display_name":"Alan N. Schechter","orcid":"https://orcid.org/0000-0002-6055-6452","observed_orcids":["https://orcid.org/0000-0002-6055-6452","https://orcid.org/0000-0002-5235-9408"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan N. Schechter","raw_affiliation_strings":["From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111464295","display_name":"Christian B. Anfinsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian B. Anfinsen","raw_affiliation_strings":["From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.8578,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94847489,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"248","issue":"16","first_page":"5821","last_page":"5825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.38280001282691956,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.38280001282691956,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.11729999631643295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micrococcal-nuclease","display_name":"staphylococcal nuclease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lanthanide-ions","display_name":"lanthanide ions","score":0.9729999899864197},{"id":"https://openalex.org/keywords/metal-binding-sites","display_name":"metal binding sites","score":0.8849999904632568},{"id":"https://openalex.org/keywords/calcium-binding-sites","display_name":"calcium binding sites","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tyrosine-residues","display_name":"tyrosine residues","score":0.6480000019073486},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.5669999718666077},{"id":"https://openalex.org/keywords/nuclease-activity","display_name":"nuclease activity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/trypsin-resistance","display_name":"trypsin resistance","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C201770740","wikidata":"https://www.wikidata.org/wiki/Q19569","display_name":"Lanthanide","level":3,"score":0.7780046463012695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6668218970298767},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.6078193187713623},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.515393853187561},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28811371326446533},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09958457946777344},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.086771160364151}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004419","descriptor_name":"Dysprosium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007811","descriptor_name":"Lanthanum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009354","descriptor_name":"Neodymium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009702","descriptor_name":"Nucleoside Diphosphate Sugars","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011221","descriptor_name":"Praseodymium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015018","descriptor_name":"Ytterbium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)43576-x","doi":"https://doi.org/10.1016/s0021-9258(19)43576-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43576-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4723899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4723899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)43576-x","doi":"https://doi.org/10.1016/s0021-9258(19)43576-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43576-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1482133448","https://openalex.org/W1496711114","https://openalex.org/W1502993156","https://openalex.org/W1517857166","https://openalex.org/W1544960916","https://openalex.org/W1547519509","https://openalex.org/W1548713531","https://openalex.org/W1559702917","https://openalex.org/W1584824397","https://openalex.org/W1596744552","https://openalex.org/W1885778179","https://openalex.org/W1975176230","https://openalex.org/W1983035697","https://openalex.org/W1983681153","https://openalex.org/W2020146552","https://openalex.org/W2034231595","https://openalex.org/W2036446927","https://openalex.org/W2048230780","https://openalex.org/W2058616804","https://openalex.org/W2080814652","https://openalex.org/W2086761717","https://openalex.org/W2087463247","https://openalex.org/W2156992886","https://openalex.org/W2411214195"],"related_works":["https://openalex.org/W1997066031","https://openalex.org/W1547519509","https://openalex.org/W1587575031","https://openalex.org/W2146398118","https://openalex.org/W1570729056","https://openalex.org/W1990842656","https://openalex.org/W1979179932","https://openalex.org/W2008850823","https://openalex.org/W2071335183","https://openalex.org/W2016973898"],"abstract_inverted_index":{"The":[0,18,65],"metal":[1],"ion-binding":[2],"site":[3,151],"of":[4,20,51,61,71,91,100,115,118,131,152,159,173],"staphylococcal":[5],"nuclease":[6,25,46,72,86,101,153],"has":[7],"been":[8],"studied":[9],"at":[10],"pH":[11],"7.0":[12],"by":[13,43,58,79,120],"using":[14,44],"several":[15],"lanthanide":[16,93,143],"ions.":[17],"binding":[19,49,70,150,172],"Gd(III)":[21],"or":[22,157,161],"Nd(III)":[23,81],"to":[24,38,73,87,133,147,176],"was":[26,56],"associated":[27],"with":[28,63,112],"tyrosine":[29],"perturbations":[30],"in":[31,97,154],"the":[32,69,92,98,106,142,148,155,171],"ultraviolet":[33],"spectrum":[34],"which":[35],"were":[36],"shown":[37],"include":[39],"tyrosine-85":[40],"and":[41,84,126],"tyrosine-115":[42],"mononitrotyrosine":[45],"derivatives.":[47],"A":[48],"constant":[50],"9":[52],"\u00b5":[53,135],"m":[54,136],"estimated":[57],"spectrophotometric":[59],"titration":[60],"nitrotyrosine-115-nuclease":[62],"Gd(III).":[64],"Ca(II)":[66,96,119,149],"required":[67],"for":[68],"deoxythymidine":[74],"3\u2032,5\u2032-diphosphate-Sepharose":[75],"could":[76],"be":[77],"replaced":[78,95],"Nd(III).":[80],"stabilized":[82],"liganded":[83],"unliganded":[85],"trypsin":[88],"digestion.":[89],"None":[90],"ions":[94,144,168],"generation":[99],"activity":[102],"toward":[103],"DNA":[104],"under":[105],"conditions":[107],"employed.":[108],"Kinetic":[109],"data":[110,139],"compatible":[111],"a":[113],"model":[114],"competitive":[116],"inhibition":[117,129],"La(III),":[121],"Pr(III),":[122],"Nd(III),":[123],"Gd(III),":[124],"Dy(III),":[125],"Yb(III)":[127],"yielded":[128],"constants":[130],"1":[132],"2":[134],".":[137],"These":[138],"suggest":[140],"that":[141],"bind":[145],"tightly":[146],"presence":[156],"absence":[158],"substrate":[160,162,174],"analogue.":[163],"As":[164],"does":[165],"Ca(II),":[166],"these":[167],"also":[169],"enhance":[170],"analogue":[175],"nuclease.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}