{"id":"https://openalex.org/W175993358","doi":"https://doi.org/10.1177/135965350801300317","title":"Suboptimal Response to Adefovir Dipivoxil Therapy for Chronic Hepatitis B in Nucleoside-Naive Patients is not due to Pre-Existing Drug-Resistant Mutants","display_name":"Suboptimal Response to Adefovir Dipivoxil Therapy for Chronic Hepatitis B in Nucleoside-Naive Patients is not due to Pre-Existing Drug-Resistant Mutants","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W175993358","doi":"https://doi.org/10.1177/135965350801300317","mag":"175993358","pmid":"https://pubmed.ncbi.nlm.nih.gov/18572751"},"language":"en","primary_location":{"id":"doi:10.1177/135965350801300317","doi":"https://doi.org/10.1177/135965350801300317","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350801300317","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350801300317","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350801300317","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043301461","display_name":"Sandra Carrou\u00e9e\u2010Durantel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210150258","display_name":"Eurofins (United States)","ror":"https://ror.org/05sy37k83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150086","https://openalex.org/I4210150258"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Sandra Carrou\u00e9e-Durantel","raw_affiliation_strings":["INSERM, U871, 69003 Lyon, France","Present address: Eurofins Viralliance Inc., Michigan, USA","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Present address: Eurofins Viralliance Inc., Michigan, USA","institution_ids":["https://openalex.org/I4210150258"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075129443","display_name":"David Durantel","orcid":"https://orcid.org/0000-0002-9226-3419","observed_orcids":["https://orcid.org/0000-0002-9226-3419"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210163327","display_name":"H\u00f4tel-Dieu de Lyon","ror":"https://ror.org/04sx7v519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210163327"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Durantel","raw_affiliation_strings":["Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","INSERM, U871, 69003 Lyon, France","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210163327"]},{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029588569","display_name":"Bettina Werle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bettina Werle-Lapostolle","raw_affiliation_strings":["INSERM, U871, 69003 Lyon, France","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090486058","display_name":"Christian Pichoud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Pichoud","raw_affiliation_strings":["INSERM, U871, 69003 Lyon, France","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081640914","display_name":"Lieve M. J. Naesens","orcid":"https://orcid.org/0000-0001-9742-9302","observed_orcids":["https://orcid.org/0000-0001-9742-9302"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lieve Naesens","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057753972","display_name":"CHRISTIAN G. TREPO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210163327","display_name":"H\u00f4tel-Dieu de Lyon","ror":"https://ror.org/04sx7v519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210163327"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Tr\u00e9po","raw_affiliation_strings":["Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","INSERM, U871, 69003 Lyon, France","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210163327"]},{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063172143","display_name":"Fabien Zoulim","orcid":"https://orcid.org/0000-0002-2245-0083","observed_orcids":["https://orcid.org/0000-0002-2245-0083"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210163327","display_name":"H\u00f4tel-Dieu de Lyon","ror":"https://ror.org/04sx7v519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210163327"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Zoulim","raw_affiliation_strings":["Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","INSERM, U871, 69003 Lyon, France","Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon, H\u00f4tel Dieu, Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 69002 Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210163327"]},{"raw_affiliation_string":"INSERM, U871, 69003 Lyon, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":5.6903,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.95799708,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"381","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adefovir-dipivoxil","display_name":"adefovir dipivoxil","score":1.0},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/virological-response","display_name":"virological response","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.652999997138977},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hbeag-positive-chronic-hepatitis-b","display_name":"HBeAg-positive hepatitis B","score":0.7049999833106995},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.6010000109672546},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lamivudine-resistance","display_name":"lamivudine resistance","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779517838","wikidata":"https://www.wikidata.org/wiki/Q353551","display_name":"Adefovir","level":5,"score":0.9010637402534485},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.7121660709381104},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.6002217531204224},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.5817681550979614},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5658812522888184},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5434695482254028},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.5032410025596619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46446532011032104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4300253391265869},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.4259015917778015},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.4164663553237915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4146270751953125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3979727029800415},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3863249719142914},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3464547395706177},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.10475236177444458}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/135965350801300317","doi":"https://doi.org/10.1177/135965350801300317","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350801300317","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350801300317","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:18572751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18572751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:HAL:hal-04942652v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04942652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antiviral Therapy, 2008","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:inserm-04123228v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-04123228","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antiviral Therapy, 2008, 13 (3), pp.381-388. &#x27E8;10.1177/135965350801300317&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1177/135965350801300317","doi":"https://doi.org/10.1177/135965350801300317","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350801300317","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350801300317","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W175993358.pdf","grobid_xml":"https://content.openalex.org/works/W175993358.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1498132922","https://openalex.org/W1569806478","https://openalex.org/W1597477033","https://openalex.org/W1840621144","https://openalex.org/W1973933851","https://openalex.org/W1979371383","https://openalex.org/W1982960788","https://openalex.org/W1985860298","https://openalex.org/W1987843876","https://openalex.org/W1994596952","https://openalex.org/W2008517556","https://openalex.org/W2009944703","https://openalex.org/W2011946598","https://openalex.org/W2016449892","https://openalex.org/W2037245607","https://openalex.org/W2055270948","https://openalex.org/W2058376942","https://openalex.org/W2068151431","https://openalex.org/W2094707861","https://openalex.org/W2108147025","https://openalex.org/W2120667564","https://openalex.org/W2125552160","https://openalex.org/W2128181119","https://openalex.org/W2129581385","https://openalex.org/W2131362526","https://openalex.org/W2138912664","https://openalex.org/W2153727610","https://openalex.org/W2156015715","https://openalex.org/W2161280033","https://openalex.org/W2164107117","https://openalex.org/W2393327590"],"related_works":["https://openalex.org/W1987321292","https://openalex.org/W1969040744","https://openalex.org/W1582127981","https://openalex.org/W2007761951","https://openalex.org/W2368455020","https://openalex.org/W2082928903","https://openalex.org/W2413582853","https://openalex.org/W2322396327","https://openalex.org/W2088280741","https://openalex.org/W2159529142"],"abstract_inverted_index":{"BACKGROUND:":[0],"Adefovir":[1],"dipivoxil":[2],"(ADV)":[3],"has":[4],"demonstrated":[5,111],"activity":[6],"against":[7],"wild-type":[8],"and":[9,155,165,222],"lamivudine-resistant":[10],"hepatitis":[11,69],"B":[12,70],"virus":[13,71],"(HBV).":[14],"After":[15],"1":[16],"year":[17],"of":[18,38,49,63,77,118,138,152,168,171,179,194,215,234,263],"therapy,":[19],"a":[20,112,124,187,248,260],"median":[21],"3.5-4.0":[22],"log10":[23,99,116,128,144],"decrease":[24],"in":[25,42,46,65,101,108,122,130,146,218,220,238],"viral":[26,50,119,131,216],"load":[27,132],"is":[28],"observed.":[29,134],"Our":[30],"aim":[31],"was":[32,133,160],"to":[33,40,44,52,80,114,126,198,231,243,265],"characterize":[34],"the":[35,45,180],"different":[36,75],"profiles":[37,76],"response":[39,79,159,182,195,236,242],"ADV":[41,64,81,244],"relation":[43],"vitro":[47,219],"susceptibility":[48,167,262],"strains":[51,217],"ADV.":[53,266],"METHODS:":[54],"In":[55],"an":[56],"international":[57],"Phase":[58],"III":[59],"randomized,":[60],"placebo-controlled":[61],"study":[62],"patients":[66,92,110,139],"positive":[67],"for":[68],"e":[72],"antigen":[73],"(HBeAg),":[74],"virological":[78],"10":[82],"mg/day":[83],"were":[84,176,184],"identified":[85],"at":[86,105,206],"week":[87,106],"48.":[88],"The":[89,135,150,162,191],"top":[90],"25%":[91,137],"(quartile":[93],"1,":[94],"Q1)":[95],"showed":[96,141,225],">":[97],"4.91":[98],"reduction":[100,117,129,145],"serum":[102],"HBV":[103,147,169,227,264],"DNA":[104,148],"48,":[107],"Q2":[109],"3.52":[113],"4.90":[115],"load,":[120],"whereas":[121],"Q3":[123],"2.22":[125,143],"3.51":[127],"bottom":[136],"(Q4)":[140,196],"<":[142],"levels.":[149],"influence":[151],"baseline":[153,207],"characteristics":[154],"drug":[156,166],"compliance":[157,255],"on":[158],"investigated.":[161],"replication":[163],"capacity":[164],"genomes":[170,228],"selected":[172],"clinical":[173],"isolates":[174],"that":[175,226],"considered":[177],"representative":[178],"treatment":[181,235],"quartiles":[183],"analysed":[185],"using":[186],"phenotypic":[188],"assay.":[189],"RESULTS:":[190],"lowest":[192],"quartile":[193],"appears":[197],"have":[199],"worse":[200],"compliance.":[201],"Higher":[202],"alanine":[203],"aminotransferase":[204],"levels":[205],"are":[208],"associated":[209],"with":[210],"improved":[211],"response.":[212],"Phenotypic":[213],"analysis":[214],"Huh7":[221],"HepG2":[223],"cells":[224],"remained":[229],"susceptible":[230],"ADV,":[232],"regardless":[233],"observed":[237],"patients.":[239],"CONCLUSION:":[240],"Suboptimal":[241],"might":[245],"result":[246],"from":[247,253,259],"host":[249],"pharmacological":[250],"effect":[251],"or":[252],"patient":[254],"issues":[256],"rather":[257],"than":[258],"reduced":[261]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}