{"id":"https://openalex.org/W175633247","doi":"https://doi.org/10.2460/ajvr.1993.54.09.1496","title":"In vitro antibacterial activity of cefoxitin and cefotetan and pharmacokinetics in dogs","display_name":"In vitro antibacterial activity of cefoxitin and cefotetan and pharmacokinetics in dogs","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W175633247","doi":"https://doi.org/10.2460/ajvr.1993.54.09.1496","mag":"175633247","pmid":"https://pubmed.ncbi.nlm.nih.gov/8239139"},"language":"en","primary_location":{"id":"doi:10.2460/ajvr.1993.54.09.1496","doi":"https://doi.org/10.2460/ajvr.1993.54.09.1496","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1993.54.09.1496","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/54/9/ajvr.1993.54.09.1496.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/54/9/ajvr.1993.54.09.1496.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071758394","display_name":"Steven W. Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven W. Petersen","raw_affiliation_strings":["From the Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111791977","display_name":"Eberhard Rosin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eberhard Rosin","raw_affiliation_strings":["From the Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706","Alameda East Veterinary Hospital, Petersen's present address is Alameda East Veterinary Hospital, 9870 East Alameda, Denver, CO 80231. 9870 East Alameda, Denver, CO 80231","From the Department of Surgical Sciences, School of Veteri-From the Department of Surgical Sciences, School of Veteri-nary Medicine, University of Wisconsin, Madison, WI 53706. Dr. nary Medicine,","University of Wisconsin, Madison, WI 53706. Dr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Alameda East Veterinary Hospital, Petersen's present address is Alameda East Veterinary Hospital, 9870 East Alameda, Denver, CO 80231. 9870 East Alameda, Denver, CO 80231","institution_ids":[]},{"raw_affiliation_string":"From the Department of Surgical Sciences, School of Veteri-From the Department of Surgical Sciences, School of Veteri-nary Medicine, University of Wisconsin, Madison, WI 53706. Dr. nary Medicine,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin, Madison, WI 53706. Dr","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.3129,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53100193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"54","issue":"9","first_page":"1496","last_page":"1499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefoxitin","display_name":"cefoxitin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cefotetan","display_name":"cefotetan","score":1.0},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antibacterial-susceptibility","display_name":"antibacterial susceptibility","score":0.8999999761581421},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.972000002861023},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5460000038146973},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.6790000200271606},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cephalosporins","display_name":"cephalosporins","score":0.75},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2777129096","wikidata":"https://www.wikidata.org/wiki/Q2602246","display_name":"Cefotetan","level":5,"score":0.9667308330535889},{"id":"https://openalex.org/C2776124114","wikidata":"https://www.wikidata.org/wiki/Q2353907","display_name":"Cefoxitin","level":4,"score":0.9422714710235596},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6200180649757385},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5594621300697327},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5252382755279541},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.48877188563346863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4863005578517914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4211590886116028},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42001962661743164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3762557804584503},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3519163727760315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22011905908584595},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1437627673149109},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.13086733222007751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061364203691482544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D015313","descriptor_name":"Cefotetan","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015313","descriptor_name":"Cefotetan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2460/ajvr.1993.54.09.1496","doi":"https://doi.org/10.2460/ajvr.1993.54.09.1496","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1993.54.09.1496","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/54/9/ajvr.1993.54.09.1496.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},{"id":"pmid:8239139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8239139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of veterinary research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2460/ajvr.1993.54.09.1496","doi":"https://doi.org/10.2460/ajvr.1993.54.09.1496","is_oa":true,"landing_page_url":"https://doi.org/10.2460/ajvr.1993.54.09.1496","pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/54/9/ajvr.1993.54.09.1496.pdf","source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W175633247.pdf","grobid_xml":"https://content.openalex.org/works/W175633247.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2409532045"],"related_works":["https://openalex.org/W1981444588","https://openalex.org/W2064560179","https://openalex.org/W2003898804","https://openalex.org/W2415504121","https://openalex.org/W2465437621","https://openalex.org/W2000793758","https://openalex.org/W2036499670","https://openalex.org/W2034014394","https://openalex.org/W2425107995","https://openalex.org/W2404051616"],"abstract_inverted_index":{"The":[0,34,81],"susceptibility":[1],"of":[2,23,29,36,49,88,90,180],"50":[3,59],"clinical":[4],"Escherichia":[5],"coli":[6,61,93,168],"isolates":[7,31,94],"to":[8,68,73,79,162],"various":[9],"antibacterials,":[10],"including":[11],"cefoxitin":[12,24,37,132,163],"and":[13,17,25,38,75,101,120,127,145,152],"cefotetan":[14,26,39,100,107,159,174],"was":[15,32,96,160],"ascertained,":[16],"the":[18,58,86,91],"minimal":[19],"inhibitory":[20],"concentration":[21],"(MIC)":[22],"for":[27,99,104,112,137],"each":[28],"these":[30],"determined.":[33],"pharmacokinetics":[35],"after":[40,125,150],"a":[41,178],"single":[42],"i.v.":[43,126,151],"or":[44,187],"SC":[45,128,153],"injection":[46],"(30":[47],"mg/kg":[48],"body":[50],"weight)":[51],"were":[52,64,71,77],"determined":[53],"in":[54,66,164,169],"4":[55,102],"dogs.":[56],"Of":[57],"E":[60,92,167],"isolates,":[62],"98%":[63],"susceptible":[65,72,78],"vitro":[67],"cefotetan,":[69],"90%":[70,89],"cefoxitin,":[74],"88%":[76],"gentamicin.":[80],"MIC":[82],"that":[83,158,173],"would":[84],"inhibit":[85],"growth":[87],"(MIC90)":[95],"0.25":[97],"microgram/ml":[98],"micrograms/ml":[103],"cefoxitin.":[105],"Plasma":[106,131],"concentrations":[108,133],"remained":[109,134],"above":[110,135],"MIC90":[111,136],"(mean":[113,138],"+/-":[114,117,122,139,142,147],"SD)":[115,140],"8.2":[116],"1.72":[118],"hours":[119,124,144,149],"13.52":[121],"0.28":[123],"administration,":[129,154],"respectively.":[130,155],"5.37":[141],"1.18":[143],"7.95":[146],"0.71":[148],"We":[156,171],"concluded":[157],"superior":[161],"activity":[165],"against":[166],"vitro.":[170],"recommend":[172],"be":[175],"given":[176],"at":[177],"dosage":[179],"30":[181],"mg/kg,":[182],"i.v.,":[183],"every":[184,189],"8":[185],"hours,":[186],"SC,":[188],"12":[190],"hours.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}