{"id":"https://openalex.org/W1755735166","doi":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","title":"Positive regulation of phenolic catabolism in Agrobacterium tumefaciens by the pcaQ gene in response to beta-carboxy-cis,cis-muconate","display_name":"Positive regulation of phenolic catabolism in Agrobacterium tumefaciens by the pcaQ gene in response to beta-carboxy-cis,cis-muconate","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W1755735166","doi":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","mag":"1755735166","pmid":"https://pubmed.ncbi.nlm.nih.gov/8501056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/204753"},"language":"en","primary_location":{"id":"doi:10.1128/jb.175.11.3529-3535.1993","doi":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/204753","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017906751","display_name":"Donna Parke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D Parke","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06511-8112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06511-8112","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017906751"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.6607,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.63994754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"175","issue":"11","first_page":"3529","last_page":"3535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agrobacterium-tumefaciens","display_name":"Agrobacterium tumefaciens","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protocatechuic-acid","display_name":"protocatechuic acid","score":0.628000020980835},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.3799999952316284},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/regulatory-elements","display_name":"regulatory elements","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8703972101211548},{"id":"https://openalex.org/C2776162087","wikidata":"https://www.wikidata.org/wiki/Q131472","display_name":"Agrobacterium tumefaciens","level":4,"score":0.8139153718948364},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6580439805984497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.595626711845398},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.5724555253982544},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5139636397361755},{"id":"https://openalex.org/C5527404","wikidata":"https://www.wikidata.org/wiki/Q2357310","display_name":"Structural gene","level":4,"score":0.4923180341720581},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.47633177042007446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4762040376663208},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4446544945240021},{"id":"https://openalex.org/C2777712861","wikidata":"https://www.wikidata.org/wiki/Q7375543","display_name":"rpoS","level":5,"score":0.43255841732025146},{"id":"https://openalex.org/C2779856404","wikidata":"https://www.wikidata.org/wiki/Q2462359","display_name":"Rhizobiaceae","level":4,"score":0.4208550453186035},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.4185643792152405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38715144991874695},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.3477434515953064},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33420056104660034},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3230479955673218},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2912428379058838},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.221614807844162},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17492279410362244},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.12466144561767578},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.05854988098144531},{"id":"https://openalex.org/C43144210","wikidata":"https://www.wikidata.org/wiki/Q121610","display_name":"Symbiosis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001089","descriptor_name":"Arabinose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001673","descriptor_name":"Biodegradation, Environmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011520","descriptor_name":"Protocatechuate-3,4-Dioxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013011","descriptor_name":"Sorbic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013011","descriptor_name":"Sorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016960","descriptor_name":"Agrobacterium tumefaciens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/jb.175.11.3529-3535.1993","doi":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.175.11.3529-3535.1993","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:78691","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/204753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:8501056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8501056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:204753","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC204753/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.880.4719","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.880.4719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.asm.org/content/175/11/3529.full.pdf","raw_type":"text"},{"id":"mag:2189298660","doi":null,"is_oa":false,"landing_page_url":"https://jb.asm.org/content/175/11/3529.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:78691","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/204753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W194917975","https://openalex.org/W256504383","https://openalex.org/W1021822166","https://openalex.org/W1481760537","https://openalex.org/W1484992296","https://openalex.org/W1491417004","https://openalex.org/W1501504477","https://openalex.org/W1507824435","https://openalex.org/W1512374553","https://openalex.org/W1521717579","https://openalex.org/W1524688180","https://openalex.org/W1555729395","https://openalex.org/W1556746304","https://openalex.org/W1558958162","https://openalex.org/W1568390953","https://openalex.org/W1586763059","https://openalex.org/W1605422454","https://openalex.org/W1605869353","https://openalex.org/W1626426536","https://openalex.org/W1698934341","https://openalex.org/W1775749144","https://openalex.org/W1805786495","https://openalex.org/W1852444935","https://openalex.org/W1877248188","https://openalex.org/W1896499155","https://openalex.org/W1948027265","https://openalex.org/W1967164846","https://openalex.org/W1972010400","https://openalex.org/W1979053604","https://openalex.org/W1981885922","https://openalex.org/W1996873503","https://openalex.org/W2010516490","https://openalex.org/W2018396914","https://openalex.org/W2021960968","https://openalex.org/W2027229485","https://openalex.org/W2028622989","https://openalex.org/W2039642528","https://openalex.org/W2043646309","https://openalex.org/W2044222658","https://openalex.org/W2046837251","https://openalex.org/W2092031384","https://openalex.org/W2096463383","https://openalex.org/W2117987081","https://openalex.org/W2127185987","https://openalex.org/W2130992353","https://openalex.org/W2144634347","https://openalex.org/W2147971579","https://openalex.org/W2155316243","https://openalex.org/W2155912133"],"related_works":["https://openalex.org/W2189298660","https://openalex.org/W2168089768","https://openalex.org/W1588039041","https://openalex.org/W1519830045","https://openalex.org/W1545227665","https://openalex.org/W2002329130","https://openalex.org/W2037324852","https://openalex.org/W7100610677","https://openalex.org/W1852444935","https://openalex.org/W2107616608"],"abstract_inverted_index":{"An":[0],"Escherichia":[1],"coli":[2,41,82],"system":[3,84],"for":[4,66],"generating":[5],"a":[6,95,121],"commercially":[7],"unavailable":[8],"catabolite":[9],"in":[10,43,75,94,129,145,183,200],"vivo":[11],"was":[12,15,85,112,115,151,177,189],"developed":[13],"and":[14,114,165],"used":[16,86],"to":[17,56,70,87,117,120,127,179,192],"facilitate":[18],"molecular":[19],"genetic":[20],"studies":[21],"of":[22,26,45,60,68,90,135,141,161],"phenolic":[23],"catabolism.":[24],"Introduction":[25],"the":[27,33,61,91,136,142,149,154,162],"plasmid-borne":[28],"Acinetobacter":[29],"pcaHG":[30],"genes,":[31],"encoding":[32],"3,4-dioxygenase":[34],"which":[35,103,124,203],"acts":[36],"on":[37],"protocatechuate,":[38],"into":[39,49,153],"E.":[40,81,130,146],"resulted":[42],"bioconversion":[44,83],"exogenously":[46],"supplied":[47],"protocatechuate":[48,62,69],"beta-carboxy-cis,cis-muconate.":[50],"This":[51],"compound":[52],"has":[53],"been":[54],"shown":[55,116,178],"be":[57,118],"an":[58],"inducer":[59],"(pca)":[63],"genes":[64,93,171,198],"required":[65],"catabolism":[67],"tricarboxylic":[71],"acid":[72],"cycle":[73],"intermediates":[74],"Rhizobium":[76],"leguminosarum":[77],"biovar":[78],"trifolii.":[79],"The":[80,100,174,185],"explore":[88],"regulation":[89],"pca":[92,170,196],"related":[96],"bacterium,":[97],"Agrobacterium":[98],"tumefaciens.":[99],"pcaD":[101,143,163],"gene,":[102],"encodes":[104],"beta-ketoadipate":[105],"enol-lactone":[106],"hydrolase,":[107],"from":[108,195],"A.":[109,155],"tumefaciens":[110,156],"A348":[111],"cloned":[113],"adjacent":[119],"regulatory":[122,137,175,187,197],"region":[123,138,176],"responds":[125],"strongly":[126],"beta-carboxy-cis,cis-muconate":[128],"coli.":[131,147],"Site-specific":[132],"insertional":[133],"mutagenesis":[134],"eliminated":[139,159],"expression":[140,160,182],"gene":[144,164,181,188],"When":[148],"mutation":[150],"incorporated":[152],"chromosome,":[157],"it":[158,194],"at":[166],"least":[167],"three":[168],"other":[169,201],"as":[172],"well.":[173],"activate":[180],"trans.":[184],"novel":[186],"termed":[190],"pcaQ":[191],"differentiate":[193],"identified":[199],"microbes,":[202],"bind":[204],"different":[205],"metabolites.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}