{"id":"https://openalex.org/W1754325972","doi":"https://doi.org/10.4049/jimmunol.169.4.1978","title":"Accelerated Clearance of Escherichia coli in Experimental Peritonitis of Histamine-Deficient Mice","display_name":"Accelerated Clearance of Escherichia coli in Experimental Peritonitis of Histamine-Deficient Mice","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1754325972","doi":"https://doi.org/10.4049/jimmunol.169.4.1978","mag":"1754325972","pmid":"https://pubmed.ncbi.nlm.nih.gov/12165523"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.169.4.1978","doi":"https://doi.org/10.4049/jimmunol.169.4.1978","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1978","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1978/1155919/1978.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1978/1155919/1978.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yoshio Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Hori","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and","\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]},{"raw_affiliation_string":"\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshihiro Nihei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Nihei","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and","\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]},{"raw_affiliation_string":"\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110763556","display_name":"Yoshimochi Kurokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimochi Kurokawa","raw_affiliation_strings":["Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010508025","display_name":"Atsuo Kuramasu","orcid":"https://orcid.org/0009-0005-4842-5184","observed_orcids":["https://orcid.org/0009-0005-4842-5184"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuo Kuramasu","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003771868","display_name":"Yoko Makabe\u2010Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Makabe-Kobayashi","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011912105","display_name":"Tadashi Terui","orcid":"https://orcid.org/0000-0002-0275-4311","observed_orcids":["https://orcid.org/0000-0002-0275-4311"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Terui","raw_affiliation_strings":["Department of Dermatology, Tohoku University Graduate School of Medicine , Sendai ,","\u2020Dermatology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"\u2020Dermatology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083850967","display_name":"Hideyuki Doi","orcid":"https://orcid.org/0000-0002-2701-3982","observed_orcids":["https://orcid.org/0000-0002-2701-3982"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Doi","raw_affiliation_strings":["Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109288344","display_name":"Susumu Satomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Satomi","raw_affiliation_strings":["Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"\u2021Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan; and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091863018","display_name":"Eiko Sakurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiko Sakurai","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011105258","display_name":"Andr\u00e1s Nagy","orcid":"https://orcid.org/0000-0003-4311-0413","observed_orcids":["https://orcid.org/0000-0003-4311-0413"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andras Nagy","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital , Toronto ,","\u00a7Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital , Toronto ,","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]},{"raw_affiliation_string":"\u00a7Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113504097","display_name":"Takehiko Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Watanabe","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074167675","display_name":"Hiroshi Ohtsu","orcid":"https://orcid.org/0000-0003-3261-8828","observed_orcids":["https://orcid.org/0000-0003-3261-8828"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ohtsu","raw_affiliation_strings":["Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","*Cellular Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine , Sendai ,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"*Cellular Pharmacology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.8432,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.69475891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"169","issue":"4","first_page":"1978","last_page":"1983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9010000228881836},{"id":"https://openalex.org/keywords/experimental-peritonitis","display_name":"experimental peritonitis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/histidine-decarboxylase","display_name":"histidine decarboxylase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/histamine-h2-receptor","display_name":"histamine H2 receptor","score":1.0},{"id":"https://openalex.org/keywords/histamine-agonists","display_name":"histamine agonists","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.828000009059906},{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mepyramine","display_name":"mepyramine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9100000262260437},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8360906839370728},{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.7998495101928711},{"id":"https://openalex.org/C2776166919","wikidata":"https://www.wikidata.org/wiki/Q5277162","display_name":"Dimaprit","level":5,"score":0.780077338218689},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7302083373069763},{"id":"https://openalex.org/C192233252","wikidata":"https://www.wikidata.org/wiki/Q421869","display_name":"Histidine decarboxylase","level":4,"score":0.7049410939216614},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.6484000086784363},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5564897060394287},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.470376193523407},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.4684351086616516},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.44244617223739624},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.43938344717025757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3882591724395752},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37756016850471497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3314182758331299},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31479430198669434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24118751287460327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23511061072349548},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.215211421251297},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19730079174041748},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19374021887779236},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.09751874208450317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08654871582984924},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006640","descriptor_name":"Histidine Decarboxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D006640","descriptor_name":"Histidine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.169.4.1978","doi":"https://doi.org/10.4049/jimmunol.169.4.1978","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1978","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1978/1155919/1978.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12165523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12165523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.169.4.1978","doi":"https://doi.org/10.4049/jimmunol.169.4.1978","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1978","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1978/1155919/1978.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1754325972.pdf","grobid_xml":"https://content.openalex.org/works/W1754325972.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1574813722","https://openalex.org/W1762975232","https://openalex.org/W1774290592","https://openalex.org/W1872008999","https://openalex.org/W1877788794","https://openalex.org/W1899364733","https://openalex.org/W1979398938","https://openalex.org/W1984259874","https://openalex.org/W1989071219","https://openalex.org/W1991203226","https://openalex.org/W2007184220","https://openalex.org/W2015794574","https://openalex.org/W2019606913","https://openalex.org/W2029389633","https://openalex.org/W2033239938","https://openalex.org/W2033950872","https://openalex.org/W2037046845","https://openalex.org/W2044863907","https://openalex.org/W2051011620","https://openalex.org/W2053975843","https://openalex.org/W2056979496","https://openalex.org/W2061443292","https://openalex.org/W2066156758","https://openalex.org/W2081166085","https://openalex.org/W2089493336","https://openalex.org/W2091102471","https://openalex.org/W2091692613","https://openalex.org/W2098574165","https://openalex.org/W2102139223","https://openalex.org/W2111718223","https://openalex.org/W2127565001","https://openalex.org/W2162804001","https://openalex.org/W2338767799","https://openalex.org/W2414696752","https://openalex.org/W2417503426","https://openalex.org/W4323285019"],"related_works":["https://openalex.org/W7097032294","https://openalex.org/W2121345310","https://openalex.org/W2907024057","https://openalex.org/W1891830593","https://openalex.org/W1989337549","https://openalex.org/W1518773720","https://openalex.org/W2082304406","https://openalex.org/W1895183397","https://openalex.org/W4254413216","https://openalex.org/W3111187503"],"abstract_inverted_index":{"We":[0],"prepared":[1],"a":[2,21,203],"model":[3],"of":[4,15,23,43,84,98,112,125,137,154,160,169,176,208,215,218],"experimental":[5],"peritonitis":[6,200],"by":[7,20],"introducing":[8],"Escherichia":[9],"coli":[10,38,51,69,100,139,198],"into":[11,39],"the":[12,16,24,30,40,44,56,64,81,96,102,110,119,135,152,157,174,177,206,213,216],"peritoneal":[13,41,65,82,103,158],"cavity":[14,104,159],"histamine-deficient":[17],"mice":[18,162],"generated":[19],"disruption":[22],"gene":[25],"for":[26,221],"histidine":[27],"decarboxylase":[28],"(HDC),":[29],"unique":[31],"histamine-synthesizing":[32],"enzyme.":[33],"When":[34],"we":[35],"inoculated":[36],"E.":[37,50,68,99,138,197],"cavities":[42],"HDC(-/-)":[45,85,106,149,161],"(histamine-deficient)":[46],"mice,":[47,73,107,150],"they":[48],"eliminated":[49],"more":[52],"efficiently":[53,62],"than":[54],"did":[55],"wild-type":[57],"mice.":[58,86,142],"Histamine":[59],"was":[60,163,171,187],"released":[61],"from":[63,101],"cells":[66,83],"after":[67],"inoculation":[70],"in":[71,80,105,140,148,156,173,195,205],"HDC(+/+)":[72,141],"although":[74],"only":[75],"trace":[76],"amounts":[77],"were":[78],"detected":[79],"Two":[87],"histamine":[88,178,186],"agonists":[89],"(6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)hepatanecarboxamide":[90],"(H(1))":[91],"and":[92,115,127,132,181],"dimaprit":[93],"(H(2)))":[94],"impaired":[95],"clearance":[97,136],"suggesting":[108],"that":[109],"activation":[111],"both":[113],"H(1)":[114,126],"H(2)":[116,128],"receptors":[117],"suppresses":[118],"clearance.":[120],"In":[121,183],"contrast,":[122],"two":[123],"kinds":[124],"receptor":[129],"antagonists,":[130],"cimetidine":[131],"pyrilamine,":[133],"promoted":[134],"Phagocytosis":[143],"appeared":[144],"to":[145,190],"be":[146,191],"enhanced":[147,167],"since":[151],"number":[153],"neutrophils":[155,170],"markedly":[164],"increased.":[165],"This":[166,210],"recruitment":[168],"suppressed":[172],"presence":[175],"agonists,":[179],"6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)hepatanecarboxamide":[180],"dimaprit.":[182],"this":[184],"report":[185],"first":[188],"shown":[189],"an":[192,196],"important":[193],"mediator":[194],"infectious":[199],"model,":[201],"causing":[202],"delay":[204],"elimination":[207],"bacteria.":[209],"also":[211],"raised":[212],"possibility":[214],"use":[217],"antihistamine":[219],"drugs":[220],"bacterial":[222],"infection.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}