{"id":"https://openalex.org/W1753854029","doi":null,"title":"Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer","display_name":"Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1753854029","mag":"1753854029"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:e48fcc35-0815-44b2-9922-24c43c628038","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1390695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/1390695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\u00c5. Bengtsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u00c5. Bengtsson","raw_affiliation_strings":["Cell Pathology, Malm\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Pathology, Malm\u00f6","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteinyl-leukotriene-receptor","display_name":"cysteinyl leukotriene receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/jnk-ap-1-signaling","display_name":"JNK/AP-1 signaling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.656000018119812},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.781000018119812},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/prostaglandin-pathway","display_name":"prostaglandin pathway","score":0.7360000014305115},{"id":"https://openalex.org/keywords/receptor-regulation","display_name":"receptor regulation","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7675532102584839},{"id":"https://openalex.org/C2777242621","wikidata":"https://www.wikidata.org/wiki/Q647917","display_name":"Leukotriene D4","level":4,"score":0.6284396648406982},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5614101886749268},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.5517978072166443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5446382164955139},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5425394773483276},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5247823596000671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48988527059555054},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4868983328342438},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.43803125619888306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39991670846939087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38832440972328186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3772585391998291},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.07916340231895447},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:e48fcc35-0815-44b2-9922-24c43c628038","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1390695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1753854029","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/search/ws/files/3889894/1390698.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:e48fcc35-0815-44b2-9922-24c43c628038","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1390695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":242,"referenced_works":["https://openalex.org/W788622","https://openalex.org/W106117070","https://openalex.org/W214964446","https://openalex.org/W1491042062","https://openalex.org/W1520044475","https://openalex.org/W1524470428","https://openalex.org/W1536690700","https://openalex.org/W1538330037","https://openalex.org/W1553717629","https://openalex.org/W1553871308","https://openalex.org/W1638465953","https://openalex.org/W1869980306","https://openalex.org/W1936798053","https://openalex.org/W1940201944","https://openalex.org/W1950421354","https://openalex.org/W1954585101","https://openalex.org/W1964224609","https://openalex.org/W1964292610","https://openalex.org/W1965037168","https://openalex.org/W1965052314","https://openalex.org/W1966894597","https://openalex.org/W1967231335","https://openalex.org/W1968102722","https://openalex.org/W1969154550","https://openalex.org/W1969770714","https://openalex.org/W1969959095","https://openalex.org/W1970316586","https://openalex.org/W1970689220","https://openalex.org/W1971303929","https://openalex.org/W1971370481","https://openalex.org/W1971701051","https://openalex.org/W1972272979","https://openalex.org/W1972456290","https://openalex.org/W1973046279","https://openalex.org/W1976382352","https://openalex.org/W1976392356","https://openalex.org/W1977394772","https://openalex.org/W1977665024","https://openalex.org/W1978591675","https://openalex.org/W1979141490","https://openalex.org/W1979618971","https://openalex.org/W1979948289","https://openalex.org/W1979991816","https://openalex.org/W1981711965","https://openalex.org/W1983262394","https://openalex.org/W1983310583","https://openalex.org/W1983832776","https://openalex.org/W1984177700","https://openalex.org/W1985063313","https://openalex.org/W1985979370","https://openalex.org/W1987453246","https://openalex.org/W1987531976","https://openalex.org/W1988491976","https://openalex.org/W1988924112","https://openalex.org/W1989856248","https://openalex.org/W1990342419","https://openalex.org/W1990404670","https://openalex.org/W1990687490","https://openalex.org/W1994219871","https://openalex.org/W1996392711","https://openalex.org/W1997561160","https://openalex.org/W1999812680","https://openalex.org/W2000131951","https://openalex.org/W2000439516","https://openalex.org/W2001258296","https://openalex.org/W2003085334","https://openalex.org/W2003789147","https://openalex.org/W2004351423","https://openalex.org/W2006602286","https://openalex.org/W2006742182","https://openalex.org/W2007187686","https://openalex.org/W2007277059","https://openalex.org/W2007649418","https://openalex.org/W2008778325","https://openalex.org/W2011783533","https://openalex.org/W2012121740","https://openalex.org/W2012920835","https://openalex.org/W2013415888","https://openalex.org/W2014288352","https://openalex.org/W2014550172","https://openalex.org/W2015479357","https://openalex.org/W2015784798","https://openalex.org/W2015801265","https://openalex.org/W2017557668","https://openalex.org/W2017937615","https://openalex.org/W2018348035","https://openalex.org/W2018402486","https://openalex.org/W2018639691","https://openalex.org/W2019266913","https://openalex.org/W2019346901","https://openalex.org/W2019355116","https://openalex.org/W2020982025","https://openalex.org/W2021562312","https://openalex.org/W2024224319","https://openalex.org/W2024866162","https://openalex.org/W2025465570","https://openalex.org/W2025647419","https://openalex.org/W2025984055","https://openalex.org/W2026086105","https://openalex.org/W2026091403","https://openalex.org/W2028170289","https://openalex.org/W2029275361","https://openalex.org/W2031423498","https://openalex.org/W2034269086","https://openalex.org/W2034951436","https://openalex.org/W2034976273","https://openalex.org/W2035827356","https://openalex.org/W2035968928","https://openalex.org/W2039238638","https://openalex.org/W2040347441","https://openalex.org/W2043150560","https://openalex.org/W2044259020","https://openalex.org/W2045488888","https://openalex.org/W2046056065","https://openalex.org/W2046208572","https://openalex.org/W2049414996","https://openalex.org/W2050182652","https://openalex.org/W2050955874","https://openalex.org/W2051998700","https://openalex.org/W2052435488","https://openalex.org/W2052735201","https://openalex.org/W2053326916","https://openalex.org/W2053383702","https://openalex.org/W2053506855","https://openalex.org/W2054549064","https://openalex.org/W2055384723","https://openalex.org/W2055430126","https://openalex.org/W2057698452","https://openalex.org/W2057918772","https://openalex.org/W2058250733","https://openalex.org/W2058374133","https://openalex.org/W2059144271","https://openalex.org/W2061474762","https://openalex.org/W2061511599","https://openalex.org/W2062236321","https://openalex.org/W2062684877","https://openalex.org/W2065307318","https://openalex.org/W2068124694","https://openalex.org/W2069012164","https://openalex.org/W2069063919","https://openalex.org/W2069412024","https://openalex.org/W2069532898","https://openalex.org/W2071108985","https://openalex.org/W2071200701","https://openalex.org/W2071247168","https://openalex.org/W2071276322","https://openalex.org/W2071289226","https://openalex.org/W2071697240","https://openalex.org/W2072287846","https://openalex.org/W2072319964","https://openalex.org/W2072401402","https://openalex.org/W2075621366","https://openalex.org/W2077841029","https://openalex.org/W2078566041","https://openalex.org/W2078844752","https://openalex.org/W2079016331","https://openalex.org/W2079745078","https://openalex.org/W2080243102","https://openalex.org/W2080781739","https://openalex.org/W2083029053","https://openalex.org/W2083623093","https://openalex.org/W2085609958","https://openalex.org/W2087019177","https://openalex.org/W2087584115","https://openalex.org/W2091463575","https://openalex.org/W2092216228","https://openalex.org/W2093531978","https://openalex.org/W2095164057","https://openalex.org/W2096451331","https://openalex.org/W2096630238","https://openalex.org/W2097733438","https://openalex.org/W2098793175","https://openalex.org/W2100723130","https://openalex.org/W2101249156","https://openalex.org/W2105594396","https://openalex.org/W2106155564","https://openalex.org/W2106988040","https://openalex.org/W2107037828","https://openalex.org/W2107648723","https://openalex.org/W2108125679","https://openalex.org/W2108315457","https://openalex.org/W2108896220","https://openalex.org/W2113203684","https://openalex.org/W2113474033","https://openalex.org/W2114103296","https://openalex.org/W2115428749","https://openalex.org/W2115711529","https://openalex.org/W2116554142","https://openalex.org/W2116594128","https://openalex.org/W2117198713","https://openalex.org/W2118001587","https://openalex.org/W2119438754","https://openalex.org/W2120890178","https://openalex.org/W2122242168","https://openalex.org/W2124076790","https://openalex.org/W2124289149","https://openalex.org/W2128484878","https://openalex.org/W2128564789","https://openalex.org/W2129256297","https://openalex.org/W2129658431","https://openalex.org/W2131464730","https://openalex.org/W2131516921","https://openalex.org/W2131885678","https://openalex.org/W2133514206","https://openalex.org/W2134165714","https://openalex.org/W2135523516","https://openalex.org/W2136303658","https://openalex.org/W2136611420","https://openalex.org/W2137463275","https://openalex.org/W2139727870","https://openalex.org/W2141487097","https://openalex.org/W2142300779","https://openalex.org/W2142541950","https://openalex.org/W2146319740","https://openalex.org/W2150586689","https://openalex.org/W2151029652","https://openalex.org/W2154750914","https://openalex.org/W2155507705","https://openalex.org/W2157135427","https://openalex.org/W2163177774","https://openalex.org/W2163353214","https://openalex.org/W2164484290","https://openalex.org/W2166525518","https://openalex.org/W2167243592","https://openalex.org/W2167331352","https://openalex.org/W2167725644","https://openalex.org/W2169752217","https://openalex.org/W2170915150","https://openalex.org/W2171451814","https://openalex.org/W2260298745","https://openalex.org/W2275576700","https://openalex.org/W2284643145","https://openalex.org/W2291339112","https://openalex.org/W2315613727","https://openalex.org/W2326330820","https://openalex.org/W2342974111","https://openalex.org/W2412130468","https://openalex.org/W2418673457","https://openalex.org/W2432510279","https://openalex.org/W2766240094","https://openalex.org/W3035220044","https://openalex.org/W4300582720"],"related_works":["https://openalex.org/W2080781739","https://openalex.org/W2126624188","https://openalex.org/W1681979718","https://openalex.org/W916400807","https://openalex.org/W1508832919","https://openalex.org/W1836877716","https://openalex.org/W2522909715","https://openalex.org/W2133514206","https://openalex.org/W4319761676","https://openalex.org/W2026617449"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,71,96,127,141,160,172,179,217],"is":[2,59,133,245],"the":[3,11,19,31,49,115,146,186,235,240],"third":[4],"most":[5],"common":[6],"type":[7],"of":[8,15,33,56,83,94,170,185,239,251],"cancer,":[9],"and":[10,54,64,81,132,152,177,183,189,192,210,219,237],"second":[12],"leading":[13],"cause":[14],"cancer-related":[16],"deaths":[17],"in":[18,43,77,126,138,158,215],"Western":[20],"world.":[21],"Chronic":[22],"inflammation,":[23],"such":[24],"as":[25],"inflammatory":[26],"bowel":[27],"diseases":[28],"(IBD),":[29],"increases":[30],"risk":[32],"cancer.":[34,253],"Cysteinyl":[35],"leukotrienes":[36],"are":[37,41,46],"pro-inflammatory":[38],"mediators":[39],"that":[40,103,208],"involved":[42,125],"IBD.":[44],"They":[45],"ligands":[47],"to":[48,92,224],"G-protein":[50],"coupled":[51],"receptors":[52,184],"CysLT1R":[53,58,75,199,209],"CysLT2R,":[55,167],"which":[57,244],"associated":[60],"with":[61,66,136],"poor":[62],"prognosis":[63,68],"CysLT2R":[65,90,130,137,156,211],"good":[67],"for":[69,166,247],"colorectal":[70,95,140,159,171,178,252],"patients.":[72],"Signaling":[73],"through":[74,89],"results":[76],"increased":[78],"proliferation,":[79],"survival":[80],"migration":[82,169],"intestinal":[84,109],"epithelial":[85,110,176],"cells,":[86],"whereas":[87],"signaling":[88],"leads":[91],"differentiation":[93],"cells.":[97],"My":[98],"main":[99],"findings":[100],"have":[101,212],"been":[102],"1)":[104],"Leukotriene":[105],"D4":[106],"(LTD4)":[107],"induces":[108],"cell":[111],"proliferation":[112],"by":[113],"activating":[114],"mitogenic":[116],"JNK":[117],"/":[118],"AP-1":[119],"pathway;":[120],"2)":[121],"The":[122,194],"mitogen":[123],"EGF,":[124],"progression,":[128,218],"down-regulates":[129],"expression":[131,157],"inversely":[134],"correlated":[135],"a":[139,164,231],"tissue":[142],"array,":[143],"while":[144,200],"3)":[145],"anti-tumorigenic":[147],"agents":[148],"all-trans":[149],"retinoic":[150],"acid":[151],"interferon":[153],"alpha":[154],"up-regulate":[155],"cells;":[161,173],"4)":[162],"LTC4,":[163],"ligand":[165],"inhibits":[168],"5)":[174],"Intestinal":[175],"cells":[180],"express":[181],"enzymes":[182],"cysteinyl":[187,241],"leukotriene":[188,242],"prostaglandin":[190],"pathways;":[191],"6)":[193],"pro-tumorigenic":[195],"cytokine":[196],"TNF-alpha":[197],"up-regulates":[198],"down-regulating":[201],"CysLT2R.":[202],"These":[203],"studies":[204],"provide":[205],"more":[206],"evidence":[207],"opposite":[213],"functions":[214],"colon":[216],"we":[220],"now":[221],"know":[222],"how":[223],"regulate":[225],"their":[226],"expression.":[227],"This":[228],"thesis":[229],"provides":[230],"basic":[232],"understanding":[233],"on":[234],"role":[236],"regulation":[238],"receptors,":[243],"useful":[246],"designing":[248],"future":[249],"therapies":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
