{"id":"https://openalex.org/W1753777637","doi":null,"title":"Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris.","display_name":"Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1753777637","mag":"1753777637","pmid":"https://pubmed.ncbi.nlm.nih.gov/19168427"},"language":"en","primary_location":{"id":"pmid:19168427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19168427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113803163","display_name":"Abbas Ali Taherian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154083","display_name":"Semnan University of Medical Sciences","ror":"https://ror.org/05y44as61","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210154083"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abbas Ali Taherian","raw_affiliation_strings":["Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran. taherian99@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran. taherian99@yahoo.com","institution_ids":["https://openalex.org/I4210154083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101729263","display_name":"Mahdi Babaei","orcid":"https://orcid.org/0009-0003-8613-0163","observed_orcids":["https://orcid.org/0009-0003-8613-0163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahdi Babaei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057333741","display_name":"Abbas Ali Vafaei","orcid":"https://orcid.org/0000-0003-1178-3787","observed_orcids":["https://orcid.org/0000-0003-1178-3787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abbas Ali Vafaei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011040601","display_name":"Morteza Jarrahi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morteza Jarrahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114375279","display_name":"Majid Jadidi","orcid":"https://orcid.org/0000-0001-6892-7695","observed_orcids":["https://orcid.org/0000-0001-6892-7695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Majid Jadidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103268501","display_name":"Hassan Mir Mohammad Sadeghi","orcid":"https://orcid.org/0000-0001-5765-0969","observed_orcids":["https://orcid.org/0000-0001-5765-0969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan Sadeghi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2189,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.58556519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"83","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyme","display_name":"thyme","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyme-extract","display_name":"thyme extract","score":0.8259999752044678},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8650000095367432},{"id":"https://openalex.org/keywords/analgesic-effect","display_name":"analgesic effect","score":0.7480000257492065},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":1.0},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9520000219345093},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.41499999165534973},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.902999997138977},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tail-flick-test","display_name":"tail-flick test","score":0.9599999785423279},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6428295373916626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6061804294586182},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5940858721733093},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5797617435455322},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5473873019218445},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5283383131027222},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.508445143699646},{"id":"https://openalex.org/C2993566434","wikidata":"https://www.wikidata.org/wiki/Q509869","display_name":"Hot plate","level":2,"score":0.4795796275138855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47228652238845825},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4702284038066864},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4374338984489441},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41934651136398315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.314802348613739},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.06331697106361389},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046930","descriptor_name":"Thymus Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19168427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19168427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.864.2926","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.864.2926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Abbas_Vafaei/publication/23938739_Antinociceptive_effects_of_hydroalcoholic_extract_of_Thymus_vulgaris/links/54b2d5120cf2318f0f953a4b.pdf?origin%3Dpublication_detail","raw_type":"text"},{"id":"mag:1753777637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19168427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W35118194","https://openalex.org/W58460486","https://openalex.org/W163935532","https://openalex.org/W167034026","https://openalex.org/W1964557797","https://openalex.org/W1968782814","https://openalex.org/W1976748894","https://openalex.org/W1982412276","https://openalex.org/W1982635838","https://openalex.org/W1984205442","https://openalex.org/W1985641848","https://openalex.org/W1986475508","https://openalex.org/W1989991378","https://openalex.org/W1994875442","https://openalex.org/W2001933690","https://openalex.org/W2008412544","https://openalex.org/W2009345240","https://openalex.org/W2011235622","https://openalex.org/W2014614933","https://openalex.org/W2020572769","https://openalex.org/W2023672939","https://openalex.org/W2025879035","https://openalex.org/W2032750810","https://openalex.org/W2036326321","https://openalex.org/W2051807250","https://openalex.org/W2057681406","https://openalex.org/W2060354797","https://openalex.org/W2063623623","https://openalex.org/W2064039725","https://openalex.org/W2064175661","https://openalex.org/W2073541816","https://openalex.org/W2074119449","https://openalex.org/W2077571550","https://openalex.org/W2078282474","https://openalex.org/W2079242302","https://openalex.org/W2098498160","https://openalex.org/W2100096820","https://openalex.org/W2107930176","https://openalex.org/W2131744401","https://openalex.org/W2159517682","https://openalex.org/W2163495539","https://openalex.org/W2206043426","https://openalex.org/W2271349088","https://openalex.org/W2413953070","https://openalex.org/W2857401692","https://openalex.org/W4406058850","https://openalex.org/W4408499265"],"related_works":["https://openalex.org/W7098316510","https://openalex.org/W4298221800","https://openalex.org/W2740639904","https://openalex.org/W2788373164","https://openalex.org/W2151480399","https://openalex.org/W2052587717","https://openalex.org/W2277403201","https://openalex.org/W2256354505","https://openalex.org/W2074119449","https://openalex.org/W2088287390"],"abstract_inverted_index":{"Previous":[0],"investigation":[1],"has":[2,196],"shown":[3],"that":[4,150,170],"Thymus":[5],"Vulgaris":[6],"(TV)":[7],"modulates":[8],"pain.":[9,183],"The":[10],"aim":[11],"of":[12,20,114,117,122,138,145],"this":[13,49],"work":[14],"was":[15,86,102,133],"to":[16,188],"examine":[17],"the":[18,115,136,139,190],"role":[19,116],"TV":[21,62,123,146,171,194],"on":[22,179,200],"acute":[23,180],"and":[24,27,34,43,65,71,74,99,109,153,174,181],"chronic":[25,100,182],"pain":[26,82,101,201],"compares":[28],"its":[29],"effect":[30,199],"with":[31,164],"dexamethasone":[32],"(DEX)":[33],"stress":[35],"(ST)":[36],"by":[37,88,104,192],"using":[38],"hot":[39,105],"plate,":[40,106],"tail":[41,107],"flick":[42,108],"formalin":[44,110],"tests":[45,160],"in":[46,56,92,120,158,162],"mice.":[47],"In":[48],"study":[50],"male":[51],"albino":[52],"mice":[53],"(25-30":[54],"g.)":[55],"21":[57],"groups":[58],"(n=147)":[59],"were":[60,77],"used.":[61],"(100,":[63],"500":[64],"1000":[66],"mg/kg),":[67],"DEX":[68,152,173],"(0.5,":[69],"1":[70,89],"2":[72],"mg/kg)":[73,144],"vehicle":[75],"(VEH)":[76],"injected":[78,134],"30":[79],"minutes":[80],"before":[81,135],"assessment":[83,113],"tests.":[84,111],"Stress":[85],"applied":[87],"min":[90],"swimming":[91],"cold":[93],"water":[94],"(18-22":[95],"degrees":[96],").":[97],"Acute":[98],"assessed":[103],"For":[112],"opioid":[118,130],"receptors":[119],"antinoceception":[121],"extract,":[124,172],"Naloxon":[125],"(NAL,":[126],"2mg/kg,":[127],"ip)":[128],"as":[129],"receptor":[131],"antagonist":[132],"injection":[137],"more":[140],"effective":[141],"dose":[142],"(500":[143],"extract.":[147],"Results":[148],"indicated":[149],"TV,":[151],"ST":[154,175],"have":[155,176],"analgesic":[156],"effects":[157,178],"all":[159],"(P<0.01":[161],"comparison":[163],"control":[165],"group).":[166],"Above":[167],"findings":[168],"showed":[169],"modulatory":[177],"Further":[184],"research":[185],"is":[186],"required":[187],"determine":[189],"mechanisms":[191],"which":[193],"extract":[195],"an":[197],"inhibitory":[198],"sensation.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}