{"id":"https://openalex.org/W1752943587","doi":null,"title":"Adiponectin: Genetic determinants and relations with subclinical cardiovascular disease","display_name":"Adiponectin: Genetic determinants and relations with subclinical cardiovascular disease","publication_year":2012,"publication_date":"2012-12-21","ids":{"openalex":"https://openalex.org/W1752943587","mag":"1752943587"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26917207","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Adiponectin_genetic_determinants_and_relations_with_subclinical_cardiovascular_disease/26917207","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/41342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016001130","display_name":"Stefan Gustafsson","orcid":"https://orcid.org/0000-0001-5894-0351","observed_orcids":["https://orcid.org/0000-0001-5894-0351"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefan Gustafsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5894-0351","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016001130"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/subclinical-cardiovascular-disease","display_name":"subclinical cardiovascular disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.8230000138282776},{"id":"https://openalex.org/keywords/n-terminal-pro-b-type-natriuretic-peptide","display_name":"N-terminal pro-brain natriuretic peptide","score":0.8999999761581421},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.8679999709129333},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-composition","display_name":"atherosclerotic plaque composition","score":0.7730000019073486},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.6890000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7599999904632568},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.7570000290870667},{"id":"https://openalex.org/keywords/adipor2","display_name":"AdipoR2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adiponectin-gene","display_name":"adiponectin gene","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.9729267358779907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6746766567230225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6154350638389587},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5907079577445984},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5506613850593567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5452809929847717},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.46440649032592773},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43430688977241516},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4144926071166992},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.36281728744506836},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.08579546213150024}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26917207","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Adiponectin_genetic_determinants_and_relations_with_subclinical_cardiovascular_disease/26917207","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41342","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41342","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1752943587","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/41342/Spikblad_Stefan_Gustafsson.pdf?sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/41342","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41342","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W180933214","https://openalex.org/W1492662981","https://openalex.org/W1562891630","https://openalex.org/W1570155932","https://openalex.org/W1965296835","https://openalex.org/W1966108962","https://openalex.org/W1969454499","https://openalex.org/W1969810072","https://openalex.org/W1974381953","https://openalex.org/W1975833412","https://openalex.org/W1976214560","https://openalex.org/W1980352305","https://openalex.org/W1981261500","https://openalex.org/W1984117395","https://openalex.org/W1988627271","https://openalex.org/W1990876629","https://openalex.org/W1991076691","https://openalex.org/W1992141724","https://openalex.org/W1997978122","https://openalex.org/W1998482930","https://openalex.org/W2001727439","https://openalex.org/W2006166466","https://openalex.org/W2006879525","https://openalex.org/W2007194743","https://openalex.org/W2008869160","https://openalex.org/W2012079899","https://openalex.org/W2013376346","https://openalex.org/W2016738173","https://openalex.org/W2017751184","https://openalex.org/W2018160380","https://openalex.org/W2018746110","https://openalex.org/W2021269530","https://openalex.org/W2024884385","https://openalex.org/W2033292054","https://openalex.org/W2035822743","https://openalex.org/W2036767439","https://openalex.org/W2041272089","https://openalex.org/W2041294944","https://openalex.org/W2042293234","https://openalex.org/W2043512342","https://openalex.org/W2046595938","https://openalex.org/W2047841158","https://openalex.org/W2048034841","https://openalex.org/W2049832267","https://openalex.org/W2050606579","https://openalex.org/W2054650580","https://openalex.org/W2059145105","https://openalex.org/W2060981158","https://openalex.org/W2060989992","https://openalex.org/W2069071723","https://openalex.org/W2075208817","https://openalex.org/W2076195725","https://openalex.org/W2077534872","https://openalex.org/W2079577417","https://openalex.org/W2080581577","https://openalex.org/W2081386131","https://openalex.org/W2094941678","https://openalex.org/W2095022880","https://openalex.org/W2096478205","https://openalex.org/W2097196651","https://openalex.org/W2097794068","https://openalex.org/W2099211155","https://openalex.org/W2101880152","https://openalex.org/W2102345576","https://openalex.org/W2102422654","https://openalex.org/W2102610155","https://openalex.org/W2102897116","https://openalex.org/W2103311860","https://openalex.org/W2103411589","https://openalex.org/W2104041304","https://openalex.org/W2105282857","https://openalex.org/W2110325808","https://openalex.org/W2113306639","https://openalex.org/W2113442851","https://openalex.org/W2117384045","https://openalex.org/W2120977310","https://openalex.org/W2121044470","https://openalex.org/W2124409609","https://openalex.org/W2124821727","https://openalex.org/W2126015369","https://openalex.org/W2128277609","https://openalex.org/W2130483595","https://openalex.org/W2130670158","https://openalex.org/W2131541226","https://openalex.org/W2132681327","https://openalex.org/W2133520037","https://openalex.org/W2134100055","https://openalex.org/W2134614230","https://openalex.org/W2134756264","https://openalex.org/W2136079696","https://openalex.org/W2137518342","https://openalex.org/W2139801418","https://openalex.org/W2141134672","https://openalex.org/W2141976211","https://openalex.org/W2142231031","https://openalex.org/W2144968122","https://openalex.org/W2147042397","https://openalex.org/W2154930292","https://openalex.org/W2156205686","https://openalex.org/W2160122910","https://openalex.org/W2160234571","https://openalex.org/W2163500926","https://openalex.org/W2163737439","https://openalex.org/W2164337546","https://openalex.org/W2168761911","https://openalex.org/W2169799551","https://openalex.org/W2184009762","https://openalex.org/W2321637064","https://openalex.org/W2416894749"],"related_works":["https://openalex.org/W2338793071","https://openalex.org/W1750303336","https://openalex.org/W1516131201","https://openalex.org/W7096383355","https://openalex.org/W2155005379","https://openalex.org/W2224841843","https://openalex.org/W2159056624","https://openalex.org/W4409227221","https://openalex.org/W2095089419","https://openalex.org/W4414190432"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"(CVD)":[2],"is":[3,31,37,79,255],"a":[4,32,56,163,190,201,258,280,293,298,354,366,383],"major":[5],"cause":[6],"of":[7,62,76,85,94,99,104,125,184,271,301,340,388,400,420,428,433,439,459],"morbidity":[8],"and":[9,14,46,74,96,116,119,127,150,206,222,238,342,372,382,405,408,436,451],"premature":[10],"death":[11],"in":[12,59,101,121,139,155,166,186,189,204,225,297,314,353,410,454,469],"Sweden":[13],"globally,":[15],"which":[16,36,160],"besides":[17],"the":[18,26,60,82,91,97,102,112,182,235,269,288,343,379,389],"substantial":[19],"individual":[20],"suffering,":[21],"puts":[22],"large":[23],"restraints":[24],"on":[25,145,275,279],"public":[27],"health":[28],"system.":[29],"Adiponectin":[30,404],"highly":[33],"heritable":[34],"trait,":[35],"strongly":[38],"associated":[39,134,199,233,240,256,307,364,395],"with":[40,135,157,200,234,241,257,308,333,365,396,431],"metabolic":[41],"disturbances":[42],"such":[43],"as":[44,244,246],"obesity":[45],"insulin":[47],"resistance.":[48],"Previous":[49],"studies":[50],"indicate":[51,162],"that":[52,129,253,305,331,346],"adiponectin":[53,100,115,131,185,196,230,254,277,289,302,310,325,341,361,380,390,397,430],"may":[54],"play":[55],"fundamental":[57],"role":[58,98,183,352],"development":[61,103],"CVD.":[63,106],"However,":[64],"further":[65],"knowledge":[66],"about":[67],"pathways":[68],"linking":[69],"circulating":[70,276,429,457,472],"adiponectin,":[71,95,228],"genetic":[72,92,273,467],"loci,":[73],"markers":[75,224,453],"early":[77],"CVD":[78],"needed.":[80],"Therefore,":[81],"overall":[83],"aim":[84],"this":[86,151],"thesis":[87],"was":[88,143,152,231,306,394],"to":[89,168,227,324,456,471],"assess":[90],"determinants":[93],"subclinical":[105],"In":[107,177,215,264,327,358],"Study":[108,178,216,265],"I,":[109],"we":[110,180,218,267,291,329],"investigated":[111],"association":[113,142],"between":[114],"cardiac":[117,137,170,335,406],"geometry":[118,407],"function":[120,138,336,409,435],"two":[122,414],"cross-sectional":[123,191],"samples":[124],"elderly":[126],"found":[128,292,330],"high":[130,360],"levels":[132,197,278,339,362,458],"were":[133,198,363],"poorer":[136],"men.":[140],"This":[141],"dependent":[144],"N-terminal":[146],"pro-brain":[147],"natriuretic":[148,175,347],"peptide":[149],"more":[153,259,367],"pronounced":[154],"individuals":[156,332],"prior":[158],"CVD,":[159],"could":[161],"counter-active":[164,356],"effect":[165],"response":[167],"decreased":[169],"function,":[171],"potentially":[172,355,384],"mediated":[173],"by":[174],"peptides.":[176],"II,":[179],"examined":[181],"vascular":[187,434],"pathology":[188],"study":[192],"design":[193],"where":[194,229],"higher":[195,207,309,338],"lower":[202],"lipid-content":[203],"plaques":[205],"vessel":[208],"wall":[209],"elasticity,":[210],"indicating":[211],"less":[212],"arterial":[213],"pathology.":[214],"III,":[217],"assessed":[219],"oxidative":[220,261,370],"stress":[221,262,371,450],"inflammatory":[223,452],"relation":[226,455,470],"positively":[232],"anti-oxidant":[236],"glutathione":[237],"inversely":[239],"lipid":[242],"peroxidation":[243],"well":[245],"epidermal":[247],"growth":[248],"factor.":[249],"Our":[250],"findings":[251,319],"suggest":[252],"beneficial":[260,368],"profile.":[263,374],"IV,":[266],"explored":[268],"impact":[270],"rare":[272,294,376],"loci":[274],"genome-wide":[281],"scale.":[282],"Besides":[283],"several":[284],"independent":[285,316],"variants":[286],"around":[287,378],"gene,":[290],"coding":[295],"variant":[296],"gene":[299,381,393],"upstream":[300,387],"receptor":[303,391],"2":[304,392],"levels.":[311,398],"If":[312],"replicated":[313],"an":[315,350],"sample,":[317],"these":[318],"can":[320],"provide":[321],"new":[322],"insight":[323],"biology.":[326],"conclusion,":[328],"poor":[334],"had":[337,349],"results":[344,412],"suggested":[345],"peptides":[348],"important":[351],"mechanism.":[357],"contrast,":[359],"arterial,":[369],"inflammation":[373],"Finally,":[375],"variation":[377,468],"novel":[385],"locus":[386],"List":[399],"scientific":[401],"papers":[402],"I.":[403],"elderly:":[411],"from":[413],"community-based":[415],"cohort":[416],"studies.":[417],"European":[418],"Journal":[419,438],"Endocrinology.":[421],"2010":[422,444],"Mar;":[423],"162(3):543-50.":[424],"https://doi.org/10.1530/EJE-09-1006":[425],"II.":[426],"Associations":[427],"measures":[432],"morphology.":[437],"Clinical":[440],"Endocrinology":[441],"&":[442],"Metabolism.":[443],"Jun;":[445],"95(6):2927-34.":[446],"https://doi.org/10.1210/jc.2009-2685":[447],"III.":[448],"Oxidative":[449],"adiponectin.":[460,473],"Obesity.":[461],"2012.":[462],"[Accepted]":[463],"https://doi.org/10.1002/oby.20097":[464],"IV.":[465],"Rare":[466],"[Manuscript]":[474]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}