{"id":"https://openalex.org/W1752880869","doi":null,"title":"Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors.","display_name":"Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W1752880869","mag":"1752880869","pmid":"https://pubmed.ncbi.nlm.nih.gov/581069"},"language":"en","primary_location":{"id":"pmid:581069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/581069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031511798","display_name":"Marilyn J. Kosloski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Kosloski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Rosen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049801834","display_name":"Richard J. Milholland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Milholland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111586290","display_name":"Demetrios Papahadjopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Papahadjopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5562,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.96861747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"38","issue":"9","first_page":"2848","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8999999761581421},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.906000018119812},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5339999794960022},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.777999997138977},{"id":"https://openalex.org/keywords/lymphosarcoma","display_name":"lymphosarcoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-cell-uptake","display_name":"tumor cell uptake","score":0.6399999856948853},{"id":"https://openalex.org/keywords/chemotherapy-efficacy","display_name":"chemotherapy efficacy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/phospholipid-vesicles","display_name":"phospholipid vesicles","score":0.7260000109672546},{"id":"https://openalex.org/keywords/octadecylamine","display_name":"octadecylamine","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.7738761901855469},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7556066513061523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6584839820861816},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5993715524673462},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5669164657592773},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.48993414640426636},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.4626736342906952},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45448043942451477},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44815361499786377},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.44494277238845825},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.41260966658592224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30364692211151123},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23918044567108154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2186983823776245},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1515038013458252},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07138407230377197}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:581069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/581069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1978-4069","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1978/3070","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1978","raw_type":"text"},{"id":"mag:1752880869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/581069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073420729","https://openalex.org/W2030998638","https://openalex.org/W2107129067","https://openalex.org/W3208875523","https://openalex.org/W2010728409","https://openalex.org/W2058197539","https://openalex.org/W2018907887","https://openalex.org/W2175975360","https://openalex.org/W2021694596","https://openalex.org/W2050420990"],"abstract_inverted_index":{"Abstract":[0],"The":[2],"possibility":[3],"of":[4,7,14,23,36,56,63,88,131,165,170,212,221,240],"the":[5,21,27,54,71,82,129,149,159,173,183,238],"use":[6],"unilamellar":[8],"phospholipid":[9],"vesicles":[10,30,77,155,200,225],"(liposomes)":[11],"as":[12,156],"carriers":[13],"methotrexate":[15],"(MTX)":[16],"was":[17,67,73,106,121,151,196],"explored":[18],"to":[19,26,158,202,244],"overcome":[20],"resistance":[22],"solid":[24,241],"tumors":[25,98,243],"drug.":[28,84,133,214],"Unilamellar":[29],"were":[31],"prepared":[32],"by":[33,126,210],"sonic":[34],"dispersion":[35],"phosphatidylcholine:cholesterol:stearylamine":[37],"(4:3:1)":[38],"in":[39,52,75,112,116,139,145,153,191,198,206,223,233],"an":[40,113],"aqueous":[41],"solution":[42],"containing":[43],"MTX.":[44,247],"In":[45],"MTX-resistant,":[46],"cortisol-sensitive":[47],"P1798":[48,97],"mouse":[49],"lymphosarcoma":[50,137,176],"cells":[51,138,231],"suspension,":[53],"uptake":[55,147],"[":[57],"3":[58],"H]MTX":[59],"at":[60,162],"a":[61,103,142,163,188,203],"concentration":[62,164],"10":[64,166],"-6":[65,167],"m":[66],"54%":[68],"greater":[69,122],"when":[70,148,194],"drug":[72,150],"encapsulated":[74,152,197],"lipid":[76,154,199,224],"than":[78,123],"that":[79,105,124,219],"observed":[80],"with":[81,108,178,229,246],"free":[83,109,132,160,213],"Daily":[85],"i.p.":[86],"injections":[87],"vesicle-entrapped":[89],"MTX":[90,146,161,179,195,222],"(1.0":[91],"mg/kg)":[92],"into":[93],"mice":[94],"bearing":[95,172],"established":[96],"for":[99],"4":[100],"consecutive":[101],"days,":[102],"regimen":[104,184],"ineffective":[107],"MTX,":[110],"resulted":[111],"80%":[114],"reduction":[115,190,205],"tumor":[117,177,192,207,230],"mass;":[118],"this":[119],"effect":[120],"achieved":[125,209],"5":[127],"times":[128],"dosage":[130],"MTX-sensitive":[134],"Murphy-Sturm":[135,175],"rat":[136,174],"suspension":[140],"showed":[141],"2.6-fold":[143],"increase":[144],"compared":[157,201],"m.":[168],"Treatment":[169],"rats":[171],"(0.5":[180],"mg/kg),":[181],"following":[182],"used":[185],"previously,":[186],"caused":[187],"82%":[189],"mass":[193,208],"52%":[204],"administration":[211],"These":[216],"results":[217],"indicate":[218],"encapsulation":[220],"enhances":[226],"its":[227],"association":[228],"vitro":[234],"and":[236],"improves":[237],"response":[239],"rodent":[242],"treatment":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
