{"id":"https://openalex.org/W1752260055","doi":null,"title":"Mast cells influence the physiological functions of fibroblasts","display_name":"Mast cells influence the physiological functions of fibroblasts","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W1752260055","mag":"1752260055"},"language":"en","primary_location":{"id":"mag:1752260055","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/40/Suppl_56/P3403.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091898855","display_name":"Mariam Bagher","orcid":"https://orcid.org/0000-0001-7594-918X","observed_orcids":["https://orcid.org/0000-0001-7594-918X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mariam Bagher","raw_affiliation_strings":["Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073247072","display_name":"Oskar H\u00e4llgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Oskar H\u00e4llgren","raw_affiliation_strings":["Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070146866","display_name":"Gunilla Westergren\u2010Thorsson","orcid":"https://orcid.org/0000-0001-5327-8805","observed_orcids":["https://orcid.org/0000-0001-5327-8805"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunilla Westergren\u2010Thorsson","raw_affiliation_strings":["Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5327-8805","affiliations":[{"raw_affiliation_string":"Medical Faculty, Lund University, Experimental Medical Sciences, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052171516","display_name":"Leif Hilding Bjermer","orcid":"https://orcid.org/0000-0002-3441-8099","observed_orcids":["https://orcid.org/0000-0002-3441-8099"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Leif Bjermer","raw_affiliation_strings":["Dep. of Respiratory Medicine and Allergology, Experimental Medical Sciences, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3441-8099","affiliations":[{"raw_affiliation_string":"Dep. of Respiratory Medicine and Allergology, Experimental Medical Sciences, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":null,"first_page":"3403","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tryptase","display_name":"tryptase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chymase","display_name":"chymase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7870000004768372},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.765999972820282},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fibroblast-migration","display_name":"fibroblast migration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780614898","wikidata":"https://www.wikidata.org/wiki/Q5118578","display_name":"Chymase","level":3,"score":0.9070651531219482},{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.8593120574951172},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.8047727346420288},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7086008787155151},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.695655107498169},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.530437707901001},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5257176756858826},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4807598292827606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4712522327899933},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4690554440021515},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.449546754360199},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4116747975349426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3611581325531006},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35138148069381714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3400658071041107},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28465503454208374},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07947090268135071},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1752260055","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/40/Suppl_56/P3403.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2905985623","https://openalex.org/W3186450910","https://openalex.org/W3118995000","https://openalex.org/W3158570273","https://openalex.org/W2890793600","https://openalex.org/W1995772162","https://openalex.org/W1994793711","https://openalex.org/W1985989552","https://openalex.org/W2747272069","https://openalex.org/W2319968689"],"abstract_inverted_index":{"Rationale:":[0],"Mast":[1,124],"cells":[2,26,233],"(MC)":[3],"play":[4,235],"a":[5,29,42,163,171],"role":[6,30,238],"in":[7,31,45,77,173,196,201,239],"allergic":[8],"disease":[9],"and":[10,18,39,66,70,87,96,108,112,114,178,185,200,214,220,242],"anaphylaxis,":[11],"by":[12,170,244],"releasing":[13],"their":[14,215],"granules":[15],"containing":[16],"pro-inflammatory":[17],"pro-fibrotic":[19],"mediators.":[20],"Recent":[21],"studies,":[22],"suggest":[23,230],"that":[24,51,212,231],"mast":[25,53,232],"may":[27,234],"have":[28],"non-allergic":[32],"chronic":[33],"lung":[34],"diseases.":[35],"Since":[36],"tissue":[37,240],"remodelling":[38,241],"fibrosis":[40,243],"is":[41,50,56],"key":[43],"feature":[44],"these":[46],"diseases":[47],"our":[48],"hypothesis":[49],"the":[52,78,83,100,152,174,197,202,221,246],"cell-fibroblast":[54],"interplay":[55],"altered.":[57],"Methods:":[59],"MC":[60,84,107,180,213],"isolated":[61],"from":[62,73],"human":[63],"peripheral":[64],"blood":[65],"fibroblasts":[67,69,72,90,109,187],"(HFL-1":[68],"primary":[71,186],"lungs)":[74],"were":[75,91,120],"used":[76],"experiments.":[79],"The":[80,191],"effects":[81],"of":[82,102,116,159,176,223,249],"proteases;":[85],"chymase":[86,133,150],"tryptase":[88,126,148],"on":[89],"analyzed":[92],"with":[93],"western":[94],"blot":[95],"q-PCR.":[97],"To":[98],"investigate":[99],"impact":[101],"cell-cell":[103,192],"interaction,":[104],"co-cultures":[105],"between":[106],"was":[110,139,168],"established":[111],"differentiation":[113],"production":[115,175,222],"extracellular":[117],"matrix":[118,205,226],"proteins":[119],"investigated.":[121],"Results:":[123],"cell":[125,130,144,153],"significantly":[127],"increased":[128,143,157],"HFL-1":[129,184],"migration":[131],"while":[132],"had":[134],"no":[135],"effect.":[136],"This":[137,167],"effect":[138],"not":[140],"due":[141],"to":[142,183],"proliferation":[145],"as":[146],"neither":[147],"nor":[149],"influenced":[151],"number.":[154],"Tryptase":[155],"triggered":[156],"expression":[158],"alpha-smooth":[160],"muscle":[161],"actin,":[162],"marker":[164],"for":[165],"myofibroblasts.":[166],"accompanied":[169],"change":[172],"collagens":[177],"proteoglycans.":[179],"adhered":[181],"directly":[182],"when":[188],"using":[189],"co-cultures.":[190],"contact":[193],"caused":[194],"alterations":[195],"fibroblast":[198,218],"phenotype":[199,219],"extra":[203,224],"cellular":[204,225],"production.":[206],"Conclusions:":[208],"These":[209],"data":[210],"indicate":[211],"mediators":[216],"influence":[217],"proteins.":[227],"Our":[228],"results":[229],"an":[236],"important":[237],"modulating":[245],"physiological":[247],"function":[248],"fibroblasts.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
