{"id":"https://openalex.org/W1751651908","doi":"https://doi.org/10.1200/jco.1996.14.1.176","title":"Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.","display_name":"Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1751651908","doi":"https://doi.org/10.1200/jco.1996.14.1.176","mag":"1751651908","pmid":"https://pubmed.ncbi.nlm.nih.gov/8558194"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1996.14.1.176","doi":"https://doi.org/10.1200/jco.1996.14.1.176","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1996.14.1.176","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1751651908"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108192653","display_name":"Heinz-Josef Lenz","orcid":"https://orcid.org/0000-0003-2178-9568","observed_orcids":["https://orcid.org/0000-0003-2178-9568"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H J Lenz","raw_affiliation_strings":["Department of Medicine, University of Southern California School of Medicine, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Southern California School of Medicine, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074248405","display_name":"Cynthia Gail Leichman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C G Leichman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071711204","display_name":"Kathleen D. Danenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K D Danenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111928165","display_name":"P. V. Danenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P V Danenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387322","display_name":"Susan G. Groshen","orcid":"https://orcid.org/0000-0001-9705-1012","observed_orcids":["https://orcid.org/0000-0001-9705-1012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Groshen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063452434","display_name":"Hartley Cohen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009097451","display_name":"Loren Laine","orcid":"https://orcid.org/0000-0002-4296-7901","observed_orcids":["https://orcid.org/0000-0002-4296-7901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Laine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091905531","display_name":"Peter F. Crookes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Crookes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047487702","display_name":"Howard Silberman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Silberman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057925246","display_name":"Joaquina Celebre Baranda","orcid":"https://orcid.org/0000-0002-0917-6307","observed_orcids":["https://orcid.org/0000-0002-0917-6307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Baranda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070697942","display_name":"Y Garcia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Garcia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110213859","display_name":"Lawrence Leichman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Leichman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3133,"has_fulltext":false,"cited_by_count":348,"citation_normalized_percentile":{"value":0.98063302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"176","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5440000295639038},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.796999990940094},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.8994190096855164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7237869501113892},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6835355758666992},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6505669951438904},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.590735137462616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.585884153842926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5478531718254089},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5359371900558472},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5241187810897827},{"id":"https://openalex.org/C2779454504","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Stomach cancer","level":3,"score":0.5032817721366882},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.4198400378227234},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40609169006347656},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.4008519649505615},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.09719061851501465}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005773","descriptor_name":"Gastroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1996.14.1.176","doi":"https://doi.org/10.1200/jco.1996.14.1.176","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1996.14.1.176","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:8558194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8558194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6272719498","display_name":null,"funder_award_id":"R01-56111","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W129822146","https://openalex.org/W1524929003","https://openalex.org/W1566892773","https://openalex.org/W1760947920","https://openalex.org/W1840795163","https://openalex.org/W1884213330","https://openalex.org/W1974590216","https://openalex.org/W1980253503","https://openalex.org/W1983706728","https://openalex.org/W2008582329","https://openalex.org/W2061193866","https://openalex.org/W2063893188","https://openalex.org/W2097033810","https://openalex.org/W2113138482","https://openalex.org/W2120764182","https://openalex.org/W2134812217","https://openalex.org/W2167847781","https://openalex.org/W2296462761","https://openalex.org/W2402825977","https://openalex.org/W2403718085","https://openalex.org/W2407770428","https://openalex.org/W4406969078"],"related_works":["https://openalex.org/W2396803645","https://openalex.org/W2376276545","https://openalex.org/W2418149173","https://openalex.org/W1802949207","https://openalex.org/W2269806819","https://openalex.org/W2356155089","https://openalex.org/W2268402331","https://openalex.org/W2413522663","https://openalex.org/W2045028264","https://openalex.org/W3038560293"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"tested":[2],"the":[3,12,22,45,64,67,74,79,83,180,193],"hypothesis":[4],"that":[5],"polymerase":[6],"chain":[7],"reaction":[8],"(PCR)":[9],"quantitation":[10],"of":[11,21,48,69,78,88,91,127,139,202,216,223],"enzyme":[13],"thymidylate":[14],"synthase":[15],"(TS)":[16],"within":[17,236],"a":[18,55,122,214,237],"primary":[19,118,146,219],"adenocarcinoma":[20],"stomach,":[23],"has":[24],"an":[25],"inverse":[26],"relationship":[27],"to":[28,133,208,228],"response":[29,207],"and":[30,82,156,182,211],"survival":[31,167,212],"for":[32,99,172,185,213],"patients":[33,116,140,158,174,217],"who":[34],"receive":[35],"fluorouracil":[36],"(5FU)-based":[37],"chemotherapy.":[38],"PATIENTS":[39],"AND":[40],"METHODS:":[41],"Before":[42],"systemic":[43],"chemotherapy,":[44],"genetic":[46,200],"expression":[47,59,201],"TS":[49,80,124,188,203],"(TSmRNA":[50,204],"level)":[51,205],"was":[52,60,109,169],"determined":[53],"using":[54],"PCR":[56,71],"method.":[57],"Gene":[58],"calculated":[61],"by":[62],"determining":[63],"ratio":[65],"between":[66],"amount":[68],"radiolabeled":[70],"product":[72],"with":[73,102,117,175,187,218],"linear":[75],"amplification":[76],"range":[77],"gene":[81],"beta-actin":[84],"gene.":[85],"Chemotherapy":[86],"consisted":[87],"two":[89],"cycles":[90],"protracted":[92],"infusion":[93],"(PI)":[94],"5FU":[95],"200":[96],"mg/m2/d":[97],"administered":[98,110],"3":[100],"weeks":[101],"leucovorin":[103],"20":[104],"mg/m2/w.":[105],"Cisplatin":[106],"100":[107],"mg/m2":[108],"on":[111,232],"day":[112],"1.":[113],"RESULTS:":[114],"Sixty-five":[115],"gastric":[119,150,220],"cancer":[120,151],"had":[121,141],"median":[123,166,181,194],"mRNA":[125],"level":[126,153],"4.6":[128],"x":[129,135],"10(-3)":[130],"(range,":[131],"0.9":[132],"20.1":[134],"10(-3)).":[136],"Thirty-five":[137],"percent":[138],"measurable":[142],"responses":[143],"in":[144,154],"their":[145],"tumors.":[147],"The":[148,165,199],"mean":[149],"TSmRNA":[152,176],"responding":[155],"resistant":[157],"is":[159],"statistically":[160],"significant":[161],"(P":[162,195],"<":[163],".001).":[164],"time":[168],"43+":[170],"months":[171,184],"treated":[173],"levels":[177,190],"less":[178],"than":[179,192],"6":[183],"those":[186],"m-RNA":[189],"greater":[191],"=":[196],".003).":[197],"CONCLUSION:":[198],"influences":[206],"5FU-based":[209],"chemotherapy":[210],"cohort":[215],"cancer.":[221],"Confirmation":[222],"these":[224],"data":[225],"could":[226],"lead":[227],"therapeutic":[229],"decisions":[230],"based":[231],"specific":[233],"molecular":[234],"properties":[235],"tumor.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}