{"id":"https://openalex.org/W1751493734","doi":"https://doi.org/10.4049/jimmunol.166.9.5733","title":"Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen","display_name":"Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W1751493734","doi":"https://doi.org/10.4049/jimmunol.166.9.5733","mag":"1751493734","pmid":"https://pubmed.ncbi.nlm.nih.gov/11313416"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.166.9.5733","doi":"https://doi.org/10.4049/jimmunol.166.9.5733","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.166.9.5733","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003534152","display_name":"Chien\u2010Fu Hung","orcid":"https://orcid.org/0000-0001-9170-7797","observed_orcids":["https://orcid.org/0000-0001-9170-7797"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chien-Fu Hung","raw_affiliation_strings":["Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA","institution_ids":["https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107072099","display_name":"Wen\u2010Fang Cheng","orcid":"https://orcid.org/0000-0002-3282-6304","observed_orcids":["https://orcid.org/0000-0002-3282-6304"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Wen-Fang Cheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University , Taipei ,","Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","\u00b6Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University , Taipei ,","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"\u00b6Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634301","display_name":"Chee\u2010Yin Chai","orcid":"https://orcid.org/0000-0003-0486-9742","observed_orcids":["https://orcid.org/0000-0003-0486-9742"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chee-Yin Chai","raw_affiliation_strings":["Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086128788","display_name":"Keng\u2010Fu Hsu","orcid":"https://orcid.org/0000-0002-2698-4971","observed_orcids":["https://orcid.org/0000-0002-2698-4971"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keng-Fu Hsu","raw_affiliation_strings":["Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100954924","display_name":"Liangmei He","orcid":"https://orcid.org/0009-0003-3597-5334","observed_orcids":["https://orcid.org/0009-0003-3597-5334"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liangmei He","raw_affiliation_strings":["Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064814823","display_name":"Morris F. Ling","orcid":"https://orcid.org/0000-0002-9657-8960","observed_orcids":["https://orcid.org/0000-0002-9657-8960"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morris Ling","raw_affiliation_strings":["Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006924305","display_name":"T.\u2010C. Wu","orcid":"https://orcid.org/0000-0003-1623-4584","observed_orcids":["https://orcid.org/0000-0003-1623-4584"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T-C Wu","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","Obstetrics and Gynecology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","Oncology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","*Pathology,","\u00a7Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21205; and","\u2020Obstetrics and Gynecology,","\u2021Molecular Microbiology and Immunology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Obstetrics and Gynecology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Oncology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Pathology, Johns Hopkins Medical Institutions , Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"*Pathology,","institution_ids":[]},{"raw_affiliation_string":"\u00a7Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21205; and","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"\u2020Obstetrics and Gynecology,","institution_ids":[]},{"raw_affiliation_string":"\u2021Molecular Microbiology and Immunology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.5693,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.95601819,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"166","issue":"9","first_page":"5733","last_page":"5740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naked-dna-vaccine","display_name":"naked DNA vaccine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vp22","display_name":"VP22","score":0.8460000157356262},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hpv16-e7","display_name":"HPV16 E7","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.5130000114440918},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6269999742507935},{"id":"https://openalex.org/keywords/vaccine-potency","display_name":"vaccine potency","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.915259599685669},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.6988459229469299},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.6482349634170532},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5127637982368469},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5058035850524902},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.490342378616333},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4556868076324463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44545698165893555},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4150243401527405},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3801542818546295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34221723675727844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3093031942844391},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18046057224273682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1599586308002472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11968860030174255},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.1116642951965332}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015678","descriptor_name":"Viral Structural Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015678","descriptor_name":"Viral Structural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015678","descriptor_name":"Viral Structural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019470","descriptor_name":"Biolistics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.166.9.5733","doi":"https://doi.org/10.4049/jimmunol.166.9.5733","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.166.9.5733","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:11313416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11313416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1807060958","display_name":null,"funder_award_id":"R01 CA72631-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2294031788","display_name":"PREVENTIVE/THERAPEUTIC HPV VACCINE DEVELOPMENT","funder_award_id":"R01CA083706","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2387033581","display_name":null,"funder_award_id":"U19 CA 72108-02","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3094256803","display_name":null,"funder_award_id":"5 POL 34582-01","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G3977294076","display_name":null,"funder_award_id":"R01 CA83706-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4138167884","display_name":"ENHANCEMENT OF HPV16 E6 &E7-SPECIFIC ANTITUMOR IMMUNITY","funder_award_id":"R01CA072631","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5861916071","display_name":"ANTIGEN-SPECIFIC VACCINES FOR BREAST CANCER","funder_award_id":"U19CA072108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1479813612","https://openalex.org/W1566505170","https://openalex.org/W1574583510","https://openalex.org/W1584683177","https://openalex.org/W1949342640","https://openalex.org/W1965261376","https://openalex.org/W1976822357","https://openalex.org/W1978146796","https://openalex.org/W2023358346","https://openalex.org/W2029613575","https://openalex.org/W2039344241","https://openalex.org/W2041026285","https://openalex.org/W2041805971","https://openalex.org/W2059483129","https://openalex.org/W2060373236","https://openalex.org/W2062078150","https://openalex.org/W2076859770","https://openalex.org/W2082089723","https://openalex.org/W2092438678","https://openalex.org/W2103053970","https://openalex.org/W2105558735","https://openalex.org/W2105668301","https://openalex.org/W2109352986","https://openalex.org/W2115912718","https://openalex.org/W2137210215","https://openalex.org/W2144882745","https://openalex.org/W2153746213","https://openalex.org/W2178523848","https://openalex.org/W2312909977","https://openalex.org/W2328992604","https://openalex.org/W4241169271"],"related_works":["https://openalex.org/W2158727199","https://openalex.org/W2040837800","https://openalex.org/W2111231927","https://openalex.org/W1566505170","https://openalex.org/W1997158699","https://openalex.org/W2112260874","https://openalex.org/W2020464572","https://openalex.org/W2026474510","https://openalex.org/W2001889320","https://openalex.org/W2032535357"],"abstract_inverted_index":{"The":[0],"potency":[1,104,123],"of":[2,26,46,70,82,124,140],"naked":[3],"DNA":[4,59,98,125],"vaccines":[5,126],"is":[6],"limited":[7],"by":[8],"their":[9],"inability":[10],"to":[11,75,114],"amplify":[12],"and":[13,29,65,93,134],"spread":[14],"in":[15,57,79,88],"vivo.":[16],"VP22,":[17],"a":[18,33,43,49,58,76,95],"HSV-1":[19],"protein,":[20],"has":[21],"demonstrated":[22],"the":[23,80,122],"remarkable":[24],"property":[25],"intercellular":[27,132],"transport":[28],"may":[30,127],"thus":[31],"provide":[32],"unique":[34],"approach":[35],"for":[36],"enhancing":[37],"vaccine":[38,60,99,116],"potency.":[39,117],"Therefore,":[40],"we":[41],"created":[42],"novel":[44],"fusion":[45],"VP22":[47],"with":[48,102],"model":[50],"Ag,":[51],"human":[52],"papillomavirus":[53],"type":[54],"16":[55],"E7,":[56],"that":[61,121],"generated":[62],"enhanced":[63,135],"spreading":[64,133],"MHC":[66,136],"class":[67,137],"I":[68,138],"presentation":[69,139],"AG:":[71],"These":[72],"properties":[73],"led":[74],"dramatic":[77],"increase":[78],"number":[81],"E7-specific":[83],"CD8(+)":[84],"T":[85],"cell":[86],"precursors":[87],"vaccinated":[89],"mice":[90],"(around":[91],"50-fold)":[92],"converted":[94],"less":[96],"effective":[97],"into":[100],"one":[101],"significant":[103],"against":[105],"E7-expressing":[106],"tumors.":[107],"In":[108],"comparison,":[109],"nonspreading":[110],"VP22(1-267)":[111],"mutants":[112],"failed":[113],"enhance":[115],"Our":[118],"data":[119],"indicated":[120],"be":[128],"dramatically":[129],"improved":[130],"through":[131],"Ag.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
