{"id":"https://openalex.org/W175118358","doi":null,"title":"Calcification of matrix vesicles in human aortic valve and aortic media.","display_name":"Calcification of matrix vesicles in human aortic valve and aortic media.","publication_year":1976,"publication_date":"1976-02-01","ids":{"openalex":"https://openalex.org/W175118358","mag":"175118358","pmid":"https://pubmed.ncbi.nlm.nih.gov/1248649"},"language":"en","primary_location":{"id":"pmid:1248649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1248649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103734701","display_name":"Kim Km","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K M Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103734701"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4961,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.92686518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"35","issue":"2","first_page":"156","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-valve-calcification","display_name":"aortic valve calcification","score":0.8610000014305115},{"id":"https://openalex.org/keywords/matrix-vesicles","display_name":"matrix vesicles","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fibroblast-senescence","display_name":"fibroblast senescence","score":0.699999988079071},{"id":"https://openalex.org/keywords/smooth-muscle-cell-degeneration","display_name":"smooth muscle cell degeneration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/apatite-crystals","display_name":"apatite crystals","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.5609999895095825},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.8700171113014221},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.8515352010726929},{"id":"https://openalex.org/C19679083","wikidata":"https://www.wikidata.org/wiki/Q3502664","display_name":"Ground substance","level":3,"score":0.6530691981315613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5838967561721802},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.551171064376831},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5378031134605408},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5182752013206482},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4997434616088867},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.4442219138145447},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.37696465849876404},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.37657344341278076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32053399085998535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26622647047042847},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25170230865478516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18862256407737732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12059560418128967},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.10830095410346985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0686647891998291},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002130","descriptor_name":"Calcium Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006882","descriptor_name":"Hydroxyapatites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1248649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1248649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},{"id":"mag:175118358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1248649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076289971","https://openalex.org/W6982598811","https://openalex.org/W2047142713","https://openalex.org/W2215432601","https://openalex.org/W1981499886","https://openalex.org/W2767700592","https://openalex.org/W2207094870","https://openalex.org/W4290332579","https://openalex.org/W2751993148","https://openalex.org/W2316531453"],"abstract_inverted_index":{"Calcification":[0],"of":[1,20,68,98,111,158],"human":[2],"aortic":[3,6],"valve":[4],"and":[5,13,36,39,62,80,164],"media":[7],"occurs":[8],"regularly,":[9],"increases":[10],"with":[11,17],"age,":[12],"is":[14],"distinctively":[15],"associated":[16],"a":[18,122,129,156,175],"zone":[19],"lipid":[21],"accumulation.":[22],"Ultrastructurally,":[23],"the":[24,48,54,65,78,112,150],"accumulated":[25],"lipids":[26],"are":[27,50,86,116,139],"seen":[28,87],"as":[29,64,174],"cellular":[30],"degradation":[31],"products":[32,44],"derived":[33,160,166],"from":[34,161,167],"senescent":[35],"degenerate":[37],"fibrocytes":[38],"smooth":[40],"muscle":[41],"cells.":[42],"The":[43,147],"when":[45],"deposited":[46],"in":[47,58,95],"matrix":[49,55,83],"morphologically":[51],"similar":[52],"to":[53,142],"vesicles":[56],"described":[57],"other":[59],"calcifying":[60,114],"tissues,":[61],"serve":[63],"initial":[66],"site":[67],"calcification":[69],"rather":[70],"than":[71],"collagen":[72],"or":[73],"elastic":[74],"fibers.":[75],"Scattered":[76],"among":[77],"smaller":[79],"more":[81,130],"typical":[82],"vesicles,":[84],"there":[85],"frequently":[88],"giant":[89],"vesicle-like":[90],"structures":[91,120],"measuring":[92],"several":[93],"microns":[94],"diameter.":[96],"Many":[97],"these":[99,143],"large":[100,113,144,151],"calcified":[101,145,152],"bodies":[102,115,153],"contain":[103],"needle-shaped,":[104],"radially":[105],"arranged":[106],"apatite":[107],"crystal":[108],"deposits.":[109],"Some":[110],"bounded":[117],"by":[118,128],"folded":[119],"suggesting":[121],"membrane":[123,163],"component,":[124],"at":[125],"times":[126],"obscured":[127],"dense":[131],"floccular":[132],"osmiophilic":[133],"deposition.":[134],"Alcianophilic":[135],"apparent":[136],"proteoglycan":[137,165],"particles":[138],"also":[140],"adherent":[141],"bodies.":[146],"substance":[148],"forming":[149],"might":[154],"be":[155],"complex":[157],"phospholipids":[159],"cell":[162],"ground":[168],"substance,":[169],"this":[170],"combination":[171],"possible":[172],"serving":[173],"nidus":[176],"for":[177],"calcification.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}