{"id":"https://openalex.org/W1750765805","doi":"https://doi.org/10.1128/mcb.7.7.2309","title":"Regulatory Function of the Saccharomyces cerevisiae Ras C-Terminus","display_name":"Regulatory Function of the Saccharomyces cerevisiae Ras C-Terminus","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W1750765805","doi":"https://doi.org/10.1128/mcb.7.7.2309","mag":"1750765805","pmid":"https://pubmed.ncbi.nlm.nih.gov/3302671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/365361"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.7.7.2309","doi":"https://doi.org/10.1128/mcb.7.7.2309","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.7.7.2309","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/365361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105726613","display_name":"Mark S. Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Marshall","raw_affiliation_strings":["Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055481417","display_name":"W. Wayt Gibbs","orcid":"https://orcid.org/0000-0003-4757-7336","observed_orcids":["https://orcid.org/0000-0003-4757-7336"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Gibbs","raw_affiliation_strings":["Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053626123","display_name":"Edward M. Scolnick","orcid":"https://orcid.org/0000-0001-9429-1547","observed_orcids":["https://orcid.org/0000-0001-9429-1547"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E M Scolnick","raw_affiliation_strings":["Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029756305","display_name":"Irving S. Sigal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I S Sigal","raw_affiliation_strings":["Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus and Celt Biology Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":null,"apc_paid":null,"fwci":3.9498,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.94918286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"7","first_page":"2309","last_page":"2315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.32670000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras1","display_name":"Ras1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ras2","display_name":"RAS2","score":1.0},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.949999988079071},{"id":"https://openalex.org/keywords/ras-activation","display_name":"Ras activation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/gtpase-activity","display_name":"GTPase activity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cdc25","display_name":"Cdc25","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/harvey-ras","display_name":"Harvey ras","score":0.625},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.82404625415802},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6503605842590332},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6468149423599243},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.516642153263092},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.4705505669116974},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42249464988708496},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.4164862632751465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3889808654785156},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33620697259902954}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.7.7.2309","doi":"https://doi.org/10.1128/mcb.7.7.2309","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.7.7.2309","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.7.7.2309-2315.1987","doi":"https://doi.org/10.1128/mcb.7.7.2309-2315.1987","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.7.7.2309-2315.1987","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:365361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/365361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:3302671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3302671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:365361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/365361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W627044590","https://openalex.org/W1502189943","https://openalex.org/W1503793517","https://openalex.org/W1513717105","https://openalex.org/W1526043578","https://openalex.org/W1562281848","https://openalex.org/W1578114531","https://openalex.org/W1802073588","https://openalex.org/W1920332992","https://openalex.org/W1973782344","https://openalex.org/W1984789478","https://openalex.org/W1988181486","https://openalex.org/W1992304591","https://openalex.org/W1992488970","https://openalex.org/W1994331967","https://openalex.org/W1998992697","https://openalex.org/W1999175930","https://openalex.org/W1999275756","https://openalex.org/W2008014792","https://openalex.org/W2014656185","https://openalex.org/W2022707104","https://openalex.org/W2042372786","https://openalex.org/W2046484554","https://openalex.org/W2046508015","https://openalex.org/W2046869089","https://openalex.org/W2049337902","https://openalex.org/W2061019978","https://openalex.org/W2065951262","https://openalex.org/W2075612889","https://openalex.org/W2077286276","https://openalex.org/W2084663419","https://openalex.org/W2089108869","https://openalex.org/W2113210366","https://openalex.org/W2131859611","https://openalex.org/W2144248875","https://openalex.org/W2144634347","https://openalex.org/W2162382740","https://openalex.org/W2323037227","https://openalex.org/W2400628512","https://openalex.org/W4211053433"],"related_works":["https://openalex.org/W2008014792","https://openalex.org/W1859718968","https://openalex.org/W2162479263","https://openalex.org/W2046950196","https://openalex.org/W2148949580","https://openalex.org/W2039489051","https://openalex.org/W2026059959","https://openalex.org/W2142130012","https://openalex.org/W1624044342","https://openalex.org/W2077286276"],"abstract_inverted_index":{"Activating":[0],"mutations":[1,93],"(valine":[2],"19":[3],"or":[4,102,119],"leucine":[5],"68)":[6],"were":[7,94],"introduced":[8,22],"into":[9,23,28],"the":[10,24,34,37,41,48,53,97,116,138,144],"Saccharomyces":[11],"cerevisiae":[12],"RAS1":[13,82,101],"and":[14,27,52,73,83,122],"RAS2":[15,31,84,103,113,141],"genes.":[16],"In":[17],"addition,":[18],"a":[19,64],"deletion":[20],"was":[21,77],"wild-type":[25],"gene":[26],"an":[29],"activated":[30,66],"gene,":[32],"removing":[33],"segment":[35],"of":[36,62,99,112,130,140],"coding":[38],"region":[39],"for":[40,79],"unique":[42],"C-terminal":[43,117,145],"domain":[44,146],"that":[45,137],"lies":[46],"between":[47],"N-terminal":[49],"174":[50],"residues":[51],"penultimate":[54],"8-residue":[55],"membrane":[56,134],"attachment":[57],"site.":[58],"At":[59],"low":[60,70],"levels":[61,72],"expression,":[63],"dominant":[65],"phenotype,":[67],"characterized":[68],"by":[69,96,110,120],"glycogen":[71],"poor":[74],"sporulation":[75],"efficiency,":[76],"observed":[78],"both":[80],"full-length":[81],"variants":[85],"having":[86],"impaired":[87],"GTP":[88],"hydrolytic":[89],"activity.":[90],"Lethal":[91],"CDC25":[92],"bypassed":[95],"expression":[98,111,139],"mutant":[100],"proteins":[104,114,142],"with":[105],"activating":[106],"amino":[107],"acid":[108],"substitutions,":[109],"lacking":[115,143],"domain,":[118],"normal":[121],"oncogenic":[123],"mammalian":[124],"Harvey":[125],"ras":[126],"proteins.":[127],"Biochemical":[128],"measurements":[129],"adenylate":[131,149],"cyclase":[132,150],"in":[133],"preparations":[135],"showed":[136],"can":[147],"restore":[148],"activity":[151],"to":[152],"cdc25":[153],"membranes.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}