{"id":"https://openalex.org/W1750516618","doi":null,"title":"The Effect of pH on Rabbit Septal Cartilage Shape Change: Exploring the Mechanism of Electromechanical Tissue Reshaping.","display_name":"The Effect of pH on Rabbit Septal Cartilage Shape Change: Exploring the Mechanism of Electromechanical Tissue Reshaping.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1750516618","mag":"1750516618","pmid":"https://pubmed.ncbi.nlm.nih.gov/25165492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080822"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4080822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080822","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110435874","display_name":"Lauren E. Tracy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E Tracy","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Calif","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023034578","display_name":"Brian J. F. Wong","orcid":"https://orcid.org/0000-0001-6318-7384","observed_orcids":["https://orcid.org/0000-0001-6318-7384"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J Wong","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Calif","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":0.626,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.69233439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":null,"first_page":"e23","last_page":"e23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septal-cartilage","display_name":"septal cartilage","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.5370000004768372},{"id":"https://openalex.org/keywords/protonation","display_name":"protonation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mechanical-deformation","display_name":"mechanical deformation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cartilage-reconstruction","display_name":"cartilage reconstruction","score":0.628000020980835},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8179861903190613},{"id":"https://openalex.org/C77056095","wikidata":"https://www.wikidata.org/wiki/Q543183","display_name":"Isotonic","level":2,"score":0.7144582271575928},{"id":"https://openalex.org/C2986098051","wikidata":"https://www.wikidata.org/wiki/Q1925011","display_name":"Shape change","level":2,"score":0.5465517044067383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5213552713394165},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.48945868015289307},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4538974165916443},{"id":"https://openalex.org/C96616956","wikidata":"https://www.wikidata.org/wiki/Q285100","display_name":"Phosphate buffered saline","level":2,"score":0.44199711084365845},{"id":"https://openalex.org/C2993697008","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Bone matrix","level":3,"score":0.4329809844493866},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.418666273355484},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3421884775161743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2697266936302185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1915067732334137},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1571211814880371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14407294988632202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13081884384155273}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4080822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Text"},{"id":"pmid:25165492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25165492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.8911","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.8911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ce/e0/eplasty14e23.PMC4080822.pdf","raw_type":"text"},{"id":"mag:1750516618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25165492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4080822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877839","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W185293224","https://openalex.org/W294328494","https://openalex.org/W563204911","https://openalex.org/W601334014","https://openalex.org/W2041162832","https://openalex.org/W2116664367","https://openalex.org/W2120875551","https://openalex.org/W2131340948","https://openalex.org/W2136264279","https://openalex.org/W2148901489","https://openalex.org/W2162051224","https://openalex.org/W2166555085","https://openalex.org/W2505055369","https://openalex.org/W3209155679"],"related_works":["https://openalex.org/W1929883743","https://openalex.org/W1987805309","https://openalex.org/W2335485726","https://openalex.org/W2120875551","https://openalex.org/W2116664367","https://openalex.org/W7167541933","https://openalex.org/W1974321657","https://openalex.org/W2143679695","https://openalex.org/W1552983363","https://openalex.org/W3024196383"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Electromechanical":[1],"reshaping":[2],"(EMR)":[3],"involves":[4],"the":[5,41,52,127,157,174,194],"application":[6],"of":[7,32,44,55,67,96,102,110,150,159,197],"an":[8,27,147],"electrical":[9],"current":[10,186],"to":[11,15,25,50,218],"mechanically":[12,70],"deformed":[13,71,79],"cartilage":[14,37,198,220],"create":[16],"sustained":[17],"tissue":[18],"shape":[19,34,59,139,171,204,221],"change.":[20,222],"Although":[21,185],"EMR":[22,45],"may":[23,199],"evolve":[24],"become":[26],"inexpensive":[28],"and":[29,72,107,126,153,162],"reliable":[30],"way":[31],"producing":[33],"change":[35,60,129,140,149,172],"in":[36,61,74,83,143,173,202],"during":[38],"reconstructive":[39],"surgery,":[40],"precise":[42],"mechanism":[43],"is":[46],"unknown.":[47],"We":[48],"aim":[49],"examine":[51],"isolated":[53,209],"effect":[54],"protonation":[56],"(pH)":[57],"on":[58],"cartilage.":[62],"METHODS:":[63],"Nasal":[64],"septal":[65],"cartilages":[66,80],"rabbits":[68],"were":[69,81,121],"placed":[73],"a":[75,94,108,167,211],"rigid":[76],"jig.":[77],"The":[78],"submerged":[82],"isotonic":[84],"phosphate":[85],"buffered":[86],"saline":[87],"baths":[88],"(osm":[89],"=":[90,99,105,113],"290":[91],"mmol/Kg)":[92],"with":[93,146],"pH":[95,101,109,158,207],"3":[97],"(N":[98,104,112],"51),":[100,106],"7":[103],"11":[111,163],"51)":[114],"for":[115],"15":[116],"minutes.":[117],"Following":[118],"re-equilibration,":[119],"specimens":[120],"removed":[122],"from":[123,130],"their":[124],"jig":[125],"angle":[128,148],"baseline":[131],"was":[132,141,178,208,215],"measured":[133],"using":[134],"digital":[135],"micrometry.":[136],"RESULTS:":[137],"Significant":[138],"noted":[142],"all":[144],"specimens,":[145],"33.6\u00b0,":[151],"33.3\u00b0,":[152],"32.0\u00b0":[154],"experienced":[155],"by":[156],"3,":[160],"7,":[161],"groups,":[164],"respectively.":[165],"Despite":[166],"trend":[168],"toward":[169],"increased":[170],"acidic":[175],"treatment,":[176],"there":[177],"no":[179],"significant":[180],"difference":[181],"between":[182],"groups.":[183],"CONCLUSIONS:":[184],"evidence":[187],"indicates":[188],"that":[189],"dynamic":[190],"oxidation-reduction":[191],"reactions":[192],"within":[193],"extracellular":[195],"matrix":[196],"be":[200],"implicated":[201],"EMR-induced":[203],"change,":[205],"when":[206],"as":[210],"single":[212],"variable":[213],"it":[214],"not":[216],"sufficient":[217],"produce":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}